Drug Delivery Device

• US 20160256611A1
• Filed: 03/04/2016
• Published: 09/08/2016
• Est. Priority Date: 03/04/2015
• Status: Abandoned Application

• Current Assignee: Microvention Incorporated (Terumo Corporation)
• Original Assignee: Microvention Incorporated (Terumo Corporation)
• Inventors: Fitz, Matthew J.
• Application Number:
  US15/061,840
• Publication Number:
  US 20160256611A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61K 47/02 Inorganic compounds
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61K 9/501 Inorganic compounds
• CPC Class Codes: A61L 2300/416 Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
• CPC Class Codes: A61L 2300/60 characterised by a special physical form
• CPC Class Codes: A61L 2300/622 Microcapsules
• CPC Class Codes: A61L 31/022 Metals or alloys
• CPC Class Codes: A61L 31/026 Ceramic or ceramic-like structures, e.g. glasses
• CPC Class Codes: A61L 31/048 obtained by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/145 Hydrogels or hydrocolloids
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence

Abstract

A drug delivery device, method of making a drug delivery device, and method of using a drug delivery device are described. The drug delivery device may be used to treat a target area within a patient'"'"'s vasculature and comprises a shell, agent, port, and an optional seal. The agent may be any number of compounds, including but not limited to a therapeutic, anti-cancer compound.

Claims

1. A drug delivery device, comprising:

a shell sized for passage through a tubular delivery device and into a vessel of a patient;

said shell having a cavity and at least one port opening between said cavity and an outside of said shell; and

,

a cancer treatment agent disposed within said cavity.

2. The drug delivery device of claim 1, further comprising a seal positioned in said at least one port.

3. The drug delivery device of claim 1, further comprising a sealing coating disposed over said shell and covering said at least one port.

4. The drug delivery device of claim 2, wherein said seal is composed of biodegradable material.

5. The drug delivery device of claim 3, wherein said sealing coating is composed of biodegradable material.

6. The drug delivery device of claim 1, wherein said shell is spherical or ovaloid.

7. The drug delivery device of claim 1, wherein an outer surface of said shell includes a flat portion.

8. The drug delivery device of claim 1, wherein said shell has a diameter between about 20-5000 microns.

9. The drug delivery device of claim 1, wherein said port has a diameter of about 20 microns.

10. The drug delivery device of claim 1, wherein said shell is composed of glass, hydrogel, nylon, PEEK, polyethylene, polyimide, platinum, palladium, tantalum, tungsten, steel, nickel-titanium, nickel-cobalt, or nickel-chromium.

11. The drug delivery device of claim 1, wherein said device is located in a carrier solution and wherein said device and said carrier solution are contained syringe.

12. The drug delivery device of claim 1, wherein said device is located in a microcatheter.

13. The drug delivery device of claim 1, wherein said port further comprises a plurality of ports.

14. The drug delivery device of claim 3, wherein said sealing coating re-seals after a 3-10 micron diameter syringe needle is inserted and removed from said at least one port.

15. The drug delivery device of claim 1, wherein said shell is formed from blow molding, casting, lost wax casting, sintering powdered metals or plastics, micro machining, 3D printing, 3D photolithography, microfabrication, MEMS technology, etching, plating, multilayer electrochemical fabrication, or a combination of these and similar techniques.

16. A method of creating a drug delivery device comprising:

forming a shell having a cavity;

forming a port into a cavity of said shell;

inserting a needle into said port and injecting a cancer treatment agent into said cavity of said shell.

17. The method of claim 16, further comprising plugging said port with a degradable seal.

18. The method of claim 16, further comprising applying a sealing coating to an outer surface of said shell.

19. The method of claim 16, wherein said forming said shell further comprises laser cutting a solid portion of material into said shell shape.

20. The method of claim 16, wherein said forming said shell further comprises casting said shell shape.