Drug Delivery Device with Front Loading Feature

• US 20160256631A1
• Filed: 10/14/2014
• Published: 09/08/2016
• Est. Priority Date: 10/16/2013
• Status: Active Application

• Current Assignee: Novo Nordisk A/S
• Original Assignee: Novo Nordisk A/S
• Inventors: Soerensen, Morten, Winther, Knud Skifter, Plambech, Christian, Windum, Jesper Peter
• Application Number:
  US15/028,848
• Publication Number:
  US 20160256631A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61M 2005/2407 from the rear
• CPC Class Codes: A61M 2005/2411 from the front
• CPC Class Codes: A61M 39/105 Multi-channel connectors or couplings, e.g. for connecting multi-lumen tubes multi-channel connectors in general F16L37/56
• CPC Class Codes: A61M 5/24 Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic ampoules or carpules A61J1/06
• CPC Class Codes: A61M 5/28 Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
• CPC Class Codes: A61M 5/3155 by rotational movement of dose setting member, e.g. during setting or filling of a syringe
• CPC Class Codes: A61M 5/3293 characterised by features of the needle hub
• CPC Class Codes: A61M 5/34 Constructions for connecting the needle , e.g. to syringe nozzle or needle hub connecting catheter tubes to hubs A61M25/0014

Abstract

The invention provides a drug delivery device adapted to receive a cartridge, the cartridge being adapted to receive a needle assembly. The drug delivery device comprises a front-loaded cartridge holder adapted to receive and hold a cartridge in a mounted state and being actuatable between an open loading state and a closed operational state. The drug delivery device is further provided with blocking means configured to prevent the cartridge holder from being actuated between the closed and the open state when a cartridge with a mounted needle assembly is held in a mounted position.

Claims

1. A drug delivery system comprising:

a cartridge comprising;

a cylindrical body portion with an axially displaceable piston,

a distal outlet portion and,

coupling structure associated with the outlet portion and adapted to engage corresponding coupling structure on a needle assembly,

a needle assembly comprising;

a hollow needle having a distal end adapted to be arranged in fluid communication with the cartridge outlet portion, and

a hub comprising coupling structure adapted to engage the cartridge coupling structure in a mounted state in which the hollow needle is arranged in fluid communication with the cartridge outlet portion,

a drug delivery device comprising;

a front-loaded cartridge holder assembly adapted to receive and hold a cartridge in a mounted state, comprising;

cartridge holding structure actuatable between;

an open loading state in which a cartridge can be received in a proximal direction and removed in a distal direction, and

a closed operational state in which a received cartridge is held in an operational mounted position,

the drug delivery system comprising;

blocking structure configured to prevent the cartridge holding structure from being actuated between the closed and the open state when a cartridge with a mounted needle assembly is held in a mounted position.

2. A drug delivery system as in claim 1, wherein the blocking structure forms part of the drug delivery device and comprises a blocking member adapted to engage a portion of a mounted needle assembly.

3. A drug delivery system as in claim 2, the cartridge holding assembly comprising:

user operated actuation structure actuatable from a closed state through an intermediate state to an open state, wherein;

the cartridge holder can be actuated from the closed state to a blocked state when the actuation structure is actuated from the closed state to the intermediate state, the blocking member thereby engaging a mounted needle assembly corresponding to a blocked position whereby actuation of the cartridge holder to the open state is prevented, and

the cartridge holder can be actuated from the closed state to the open state when the actuation structure is actuated from the closed state through the intermediate state to an open state with no needle assembly being mounted, this allowing the blocking member to be moved past the blocked position.

4. A drug delivery system as in claim 3, wherein the cartridge holder comprises holding structure in the form of first and second axially moveable cartridge holder members each comprising a distal gripping portion adapted to grip and move proximally a partially inserted cartridge when the actuation structure is actuated from the open state to the closed state,

wherein the first cartridge holder member is moved distally and thereby out of gripping engagement with a loaded cartridge before the second cartridge holder member is moved distally when the actuation structure is actuated from the closed state to the open state,

whereby the first cartridge holder member will engage a mounted needle assembly corresponding to the blocked position whereby further actuation of the actuation structure is prevented, the first cartridge holder member thereby serving as the blocking member.

5. A drug delivery system as in claim 4, wherein the gripping portion of a cartridge holder member is moved inwards when the corresponding cartridge holder member is moved proximally and is moved outwards when the corresponding cartridge holder member is moved distally.

6. A drug delivery system as in claim 1, wherein the blocking structure forms part of the drug delivery device and comprises a blocking member adapted to be moved to a blocking position when a needle assembly is mounted on a mounted cartridge.

7. A drug delivery system as in claim 6, wherein the blocking structure is moved proximally to thereby block the actuation structure.

8. A drug delivery system as in claim 2, the cartridge holding assembly comprising user operated actuation structure actuatable from a closed state through an intermediate state to an open state, wherein:

the blocking structure comprises a blocking member adapted to be moved proximally when the actuation structure is actuated from the open state to the closed state, and to be moved distally corresponding to the intermediate state before the cartridge holding structure is actuated from the closed state to the open state,

whereby the blocking member will engage a mounted needle assembly thereby preventing further actuation of the actuation structure.

9. A drug delivery system as in claim 1, wherein:

the cartridge holding assembly comprises user operated actuation structure for actuating the cartridge holder between the open state and the closed state, and

the needle assembly hub comprises the blocking structure, the blocking structure being adapted to block the actuation structure.

10. A drug delivery system as in claim 9, wherein the actuation structure comprises a portion arranged at the distal end of the cartridge holder assembly and being adapted to engage the blocking structure of a mounted needle assembly when the actuation structure is actuated for actuating the cartridge holder from the closed state to the open state.

11. A drug delivery system as in claim 10, wherein the actuation structure is adapted to be moved in a distal direction when actuating the cartridge holder from the closed state to the open state, the blocking structure being in the form of a proximally facing surface adapted to engage the actuation structure.

12. A method of operating a drug delivery system, comprising the steps of:

providing a drug cartridge having distal coupling structure adapted to engage corresponding coupling structure on a needle assembly,

providing a needle assembly having a hub comprising coupling structure adapted to engage the cartridge coupling structure in a mounted state,

providing a drug delivery device having a front-loaded cartridge holder comprising

cartridge holding structure actuatable between an open loading state in which a cartridge can be received in a proximal direction and removed in a distal direction, and a closed operational state in which a received cartridge is held in an operational mounted position,

inserting the drug cartridge in the cartridge holder,

actuating the cartridge holding structure from the open state to the closed state, and

mounting a needle assembly on the cartridge distal coupling, the mounting of the needle assembly blocking the cartridge holding structure from being actuated from the closed state to the open state when the needle assembly is mounted.

13. A method of operating a drug delivery system as in claim 12, wherein the provided drug delivery device comprises blocking structure actuated by mounting of the needle assembly.