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EXOSOME RECOVERY METHODS WITH LOW MOLECULAR WEIGHT ORGANIC ZWITTERIONS

  • US 20160266097A1
  • Filed: 10/15/2014
  • Published: 09/15/2016
  • Est. Priority Date: 10/24/2013
  • Status: Active Grant
First Claim
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1. A method of isolating exosomes comprising:

  • conducting at least one purification step in the presence of an organic zwitterion having a molecular weight of less than about 350 Daltons, wherein a buffering pK of a negatively charged portion of the organic zwitterion is at least one full pH unit below an operating pH at which the at least one purification step is conducted, and a buffering pK of a positively charged portion of the organic zwitterion is at least one full pH unit above the operating pH.

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