ANTI-PD-1 ANTIBODY AND USE THEREOF
First Claim
1. An antibody or a functional fragment thereof that can bind to the programmed cell death 1 (PD-1) protein and comprises a heavy-chain comprising a heavy-chain complementarity-determining region (CDR) having an amino acid sequence selected from the group consisting of SEQ ID NO:
- 1, 2, 3, 7, 8, 9, 13, 14 and 15, and/or a light-chain comprising a light-chain CDR having an amino acid sequence selected from the group consisting of SEQ ID NO;
4, 5, 6, 10, 11, 12, 16, 17 and 18.
3 Assignments
0 Petitions
Accused Products
Abstract
This invention provides antibodies or functional fragments thereof that bind to PD-1 with high affinity. The invention provides nucleic acid molecules encoding the antibodies or the fragments thereof according to the present invention, expression vectors and host cells for expressing the antibodies or the functional fragments thereof according to the present invention, as well as methods for producing the antibodies or the functional fragments thereof according to the present invention. The present invention also provides immunoconjugates and pharmaceutical compositions comprising the antibodies or the functional fragments thereof according to the present invention. The present invention additionally provides methods for treating a plurality of diseases (comprising cancers, infectious diseases and inflammatory diseases) by using the antibodies or the functional fragments thereof disclosed herein.
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Citations
15 Claims
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1. An antibody or a functional fragment thereof that can bind to the programmed cell death 1 (PD-1) protein and comprises a heavy-chain comprising a heavy-chain complementarity-determining region (CDR) having an amino acid sequence selected from the group consisting of SEQ ID NO:
- 1, 2, 3, 7, 8, 9, 13, 14 and 15, and/or a light-chain comprising a light-chain CDR having an amino acid sequence selected from the group consisting of SEQ ID NO;
4, 5, 6, 10, 11, 12, 16, 17 and 18. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
- 1, 2, 3, 7, 8, 9, 13, 14 and 15, and/or a light-chain comprising a light-chain CDR having an amino acid sequence selected from the group consisting of SEQ ID NO;
Specification