COMPOSITIONS AND METHODS FOR INCREASING ENERGY METABOLISM
First Claim
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1. A composition effective for enhancing energy metabolism comprising:
- a) a phosphodiesterase 5 (PDE
5) inhibitor; and
b) leucine and/or a leucine metabolite.
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Abstract
Compositions and methods useful for inducing an increase in fatty acid oxidation or mitochondrial biogenesis, reducing weight gain, inducing weight loss, or increasing Sirt1, Sirt3, or AMPK activity are provided herein. Such compositions comprise a combination of a PDE 5 inhibitor, such as sildenafil or icariin, and resveratrol, and a branched amino acid such as leucine, or its metabolite.
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Citations
47 Claims
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1. A composition effective for enhancing energy metabolism comprising:
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a) a phosphodiesterase 5 (PDE
5) inhibitor; andb) leucine and/or a leucine metabolite. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 30, 31, 32, 36, 47)
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25. A composition effective for enhancing energy metabolism comprising:
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a) a PDE 5 inhibitor; and b) a polyphenol, wherein the composition enhances energy metabolism in the subject to a greater degree as compared to administering to the subject component (a) or component (b) alone. - View Dependent Claims (26, 27, 28, 29)
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- 33. A method of regulating energy metabolism in a subject in need thereof comprising administering to the subject a unit dosage comprising a subtherapeutic amount of a PDE 5 inhibitor and, at least about 500 mg of leucine or about 200 mg of HMB.
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37. A method of treating diabetes in a subject in need thereof, comprising administering to the subject a therapeutically effective composition comprising:
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a) a PDE inhibitor; and b) a branched-chain amino acid in free amino acid form or a free metabolite thereof. - View Dependent Claims (38, 39, 40, 41, 42, 43, 44, 45, 46)
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Specification