BIOLOGICAL INFORMATION MEASUREMENT SYSTEM

• US 20160287099A1
• Filed: 03/28/2016
• Published: 10/06/2016
• Est. Priority Date: 03/30/2015
• Status: Active Grant

• Current Assignee: Nihon Kohden Corporation
• Original Assignee: Nihon Kohden Corporation
• Inventors: Kobayashi, Naoki
• Granted Patent: US 10,548,493 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61B 5/02422 within occluders
• CPC Class Codes: A61B 5/0261 using optical means, e.g. infrared light
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61M 2205/3313 used specific wavelengths
• CPC Class Codes: A61M 2230/205 partial oxygen pressure (P-O2)

Abstract

A light emitting unit emits first light and second light having different wavelengths. A photoreception unit outputs first and second signals depending on photoreception intensities of the first and second light transmitted through or reflected by biological tissue. A processing period setting unit extracts a signal cycle corresponding to the cardiac cycle for the first or second signal and sets a processing period in a first part dominantly affected by arterial blood flowing to the tissue or a second part dominantly affected by venous blood flowing from the tissue in the signal cycle. First and second change amount acquisition units obtain first and second change amounts corresponding to the attenuation change amounts of the first and second light from the first and second signals in the processing period. A concentration calculation unit calculates the concentration of light absorbing substance in blood from the first and second change amounts.

Claims

1. A biological information measurement system comprising:

a light emitting unit configured to emit first light having a first wavelength and second light having a second wavelength;

a photoreception unit configured to output a first signal and a second signal depending on photoreception intensity of the first light and photoreception intensity of the second light that has passed through biological tissue of a subject or that is reflected by the biological tissue of the subject;

a processing period setting unit configured to extract a signal cycle corresponding to a cardiac cycle of the subject for one of the first signal and the second signal, and further configured to set a first processing period in one of a first period in which an effect of arterial blood flowing to the biological tissue is dominant and a second period in which an effect of venous blood flowing from the biological tissue is dominant in the signal cycle;

a first change amount acquisition unit configured to obtain a first change amount corresponding to an attenuation change amount of the first light based on the first signal in the first processing period;

a second change amount acquisition unit configured to obtain a second change amount corresponding to an attenuation change amount of the second light based on the second signal in the first processing period;

a first concentration calculation unit configured to calculate a first concentration of a light absorbing substance in blood of the subject based on the first change amount and the second change amount; and

an output unit configured to provide the first concentration.

2. The biological information measurement system according to claim 1, further comprising:

a differential signal acquisition unit configured to obtain a differential signal by differentiating the one of the first signal and the second signal,

wherein the processing period setting unit configured to set the first processing period in the first period based on a minimum value of the differential signal.

3. The biological information measurement system according to claim 1, further comprising:

a differential signal acquisition unit configured to obtain a differential signal by differentiating the one of the first signal and the second signal,

wherein the processing period setting unit is configured to set the first processing period in the second period based on a maximum value of the differential signal.

4. The biological information measurement system according to claim 1,

wherein the light absorbing substance is oxyhemoglobin or deoxyhemoglobin.

5. The biological information measurement system according to claim 1,

wherein the light absorbing substance is a dye.

6. The biological information measurement system according to claim 1, wherein the one of the first signal and the second signal is the first signal,

wherein the one of the first period and the second period is the first period,

wherein the processing period setting unit is further configured to extract the signal cycle corresponding to the cardiac cycle of the subject for the second signal, and further configured to set a second processing period in the second period,

wherein the biological information measurement system further comprises:

a third change amount acquisition unit configured to obtain a third change amount corresponding to an attenuation change amount of the first light in the second processing period based on the first signal in the second processing period;

a fourth change amount acquisition unit configured to obtain a fourth change amount corresponding to an attenuation change amount of the second light in the second processing period based on the second signal in the second processing period;

a second concentration calculation unit configured to calculate a second concentration corresponding to the concentration of the light absorbing substance in blood of the subject in the second processing period based on the third change amount and the fourth change amount; and

a transit time calculation unit configured to calculate a transit time of blood in the biological tissue based on the first concentration and the second concentration, and

wherein the output unit is further configured to provide at least one of the first concentration, the second concentration, and the transit time.

7. The biological information measurement system according to claim 6,

wherein the transit time calculation unit is configured to calculate the transit time based on a time difference between a time when the first concentration becomes the maximum and a time when the second concentration becomes the maximum.

8. The biological information measurement system according to claim 6,

wherein the transit time calculation unit is configured to calculate the transit time based on a time difference between a time when the first concentration exceeds a threshold and a time when the second concentration exceeds the threshold.

9. The biological information measurement system according to claim 6,

wherein the transit time calculation unit is configured to calculate the transit time based on a difference between a first mean transit time acquired based on time-dependent change of the first concentration and a second mean transit time acquired based on time-dependent change of the second concentration.

10. The biological information measurement system according to claim 6,

wherein the transit time calculation unit is configured to calculate the transit time based on a cross correlation function between the first concentration and the second concentration.

11. The biological information measurement system according to claim 1, further comprising:

an air circuit configured to supply air to be inhaled by the subject; and

an oxygen concentration adjusting unit configured to adjust a concentration of oxygen included in the air.

12. The biological information measurement system according to claim 1, further comprising:

a cuff attachable to the subject configured to press a blood flow upstream side of the biological tissue; and

a pressure control unit configured to control pressure of the cuff.

13. The biological information measurement system according to claim 6, further comprising:

a notifying unit configured to notify when the transit time is outside a predetermined range.

14. A biological information measurement system comprising:

a light emitting unit configured to emit first light having a first wavelength and second light having a second wavelength;

a photoreception unit configured to output a first signal and a second signal depending on photoreception intensity of the first light and photoreception intensity of the second light that has passed through biological tissue of a subject or that is reflected by the biological tissue of the subject;

a correlation coefficient acquisition unit configured to obtain a correlation coefficient between the first signal and the second signal;

a transit time calculation unit configured to calculate a transit time of blood in the biological tissue based on time-dependent change of the correlation coefficient; and

an output unit configured to provide the transit time.

15. The biological information measurement system according to claim 14, further comprising:

a notifying unit configured to notify when the transit time is outside a predetermined range.

16. A method of measuring biological information, comprising:

emitting first light having a first wavelength and second light having a second wavelength;

outputting a first signal and a second signal depending on photoreception intensity of the first light and photoreception intensity of the second light that has passed through biological tissue of a subject or that is reflected by the biological tissue of the subject;

extracting a signal cycle corresponding to a cardiac cycle of the subject for one of the first signal and the second signal;

setting a first processing period in one of a first period in which an effect of arterial blood flowing to the biological tissue is dominant and a second period in which an effect of venous blood flowing from the biological tissue is dominant in the signal cycle;

obtaining a first change amount corresponding to an attenuation change amount of the first light based on the first signal in the first processing period;

obtaining a second change amount corresponding to an attenuation change amount of the second light based on the second signal in the first processing period;

calculating a first concentration of a light absorbing substance in blood of the subject based on the first change amount and the second change amount; and

providing a calculated result.

17. The method of claim 16, further comprising:

obtaining a differential signal by differentiating the one of the first signal and the second signal; and

setting the first processing period in the first period based on a minimum value of the differential signal.

18. The method of claim 16, further comprising:

obtaining a differential signal by differentiating the one of the first signal and the second signal; and

setting the first processing period in the second period based on a maximum value of the differential signal.

19. The method of claim 16, wherein the one of the first signal and the second signal is the first signal,

wherein the one of the first period and the second period is the first period,

wherein the method further comprises:

extracting the signal cycle corresponding to the cardiac cycle of the subject for the second signal;

setting a second processing period in the second period;

obtaining a third change amount corresponding to an attenuation change amount of the first light in the second processing period based on the first signal in the second processing period;

obtaining a fourth change amount corresponding to an attenuation change amount of the second light in the second processing period based on the second signal in the second processing period;

calculating a second concentration corresponding to the concentration of the light absorbing substance in blood of the subject in the second processing period based on the third change amount and the fourth change amount; and

calculating a transit time of blood in the biological tissue based on the first concentration and the second concentration.

20. The method of claim 16, further comprising:

obtaining a correlation coefficient between the first signal and the second signal; and

calculating a transit time of blood in the biological tissue based on time-dependent change of the correlation coefficient.