TOLL LIKE RECEPTOR MODULATOR COMPOUNDS

• US 20160289229A1
• Filed: 03/02/2016
• Published: 10/06/2016
• Est. Priority Date: 03/04/2015
• Status: Active Grant

• Current Assignee: Gilead Sciences Inc.
• Original Assignee: Gilead Sciences Inc.
• Inventors: Aktoudianakis, Evangelos, Chin, Gregory, Mackman, Richard L., Metobo, Samuel E., Mish, Michael R., Pyun, Hyung-jung, Zablocki, Jeff
• Granted Patent: US 9,670,205 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61K 31/517 ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
• CPC Class Codes: A61P 31/18 for HIV
• CPC Class Codes: A61P 31/20 for DNA viruses
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: C07D 239/84 Nitrogen atoms
• CPC Class Codes: C07D 401/04 directly linked by a ring-member-to-ring-member bond
• CPC Class Codes: C07D 471/04 Ortho-condensed systems

Abstract

The present disclosure relates generally to toll like receptor modulator compounds, such as diamino pyrido[3,2 D]pyrimidine compounds and pharmaceutical compositions which, among other things, modulate toll-like receptors (e.g. TLR-8), and methods of making and using them.

Claims

1-102. -102. (canceled)

103. A compound which is

105. A pharmaceutical composition comprising the compound claim 103 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

104. A compound which is

106. A pharmaceutical composition comprising the compound of claim 104, and a pharmaceutically acceptable excipient.

107. A compound which is

109. A pharmaceutical composition comprising the compound claim 107 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

108. A compound which is

110. A pharmaceutical composition comprising the compound of claim 108, and a pharmaceutically acceptable excipient.

111. A compound which is

113. A pharmaceutical composition comprising the compound of claim 111 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

112. A compound which is

114. A pharmaceutical composition comprising the compound of claim 112, and a pharmaceutically acceptable excipient.

115. A compound which is

117. A pharmaceutical composition comprising the compound of claim 115 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

116. A compound which is

118. A pharmaceutical composition comprising the compound of claim 116, and a pharmaceutically acceptable excipient.