Redox Polymers
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Accused Products
Abstract
Novel transition metal complexes of iron, cobalt, ruthenium, osmium, and vanadium are described. The transition metal complexes can be used as redox mediators in enzyme based electrochemical sensors. In such instances, transition metal complexes accept electrons from, or transfer electrons to, enzymes at a high rate and also exchange electrons rapidly with the sensor. The transition metal complexes include at least one substituted or unsubstituted biimidazole ligand and may further include a second substituted or unsubstituted biimidazole ligand or a substituted or unsubstituted bipyridine or pyridylimidazole ligand. Transition metal complexes attached to polymeric backbones are also described.
1 Citation
36 Claims
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1-15. -15. (canceled)
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16. An analyte sensor comprising:
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a substrate comprising a non-conductive base material, wherein the substrate comprises a first surface and a second surface that is opposite the first surface; a counter electrode disposed on the first surface of the substrate; a working electrode comprising a conductive layer disposed on the second surface of the substrate; and a reagent positioned on the working electrode, the reagent comprising; an analyte responsive enzyme; and a mediator comprising a polymeric transition metal complex comprising; a polymer backbone; and at least one spacer attached to the polymer backbone, the at least one spacer comprising at least one non-cyclic functional group selected from the group consisting of —
(CRrRs)—
, —
O—
, —
S—
, —
C(O)O—
, —
S(O)2NRk, —
OC(O)NRm—
, —
OC(S)NRn, —
C(O)NRt—
, —
NRu—
, —
CRv═
N—
O—
, —
CRw═
NNRx—
, and —
(SiRyRz)—
, and wherein Rr and Rs are independently hydrogen, chlorine, fluorine, or substituted or unsubstituted alkyl, alkoxy, alkenyl, or alkynyl, and Rk, Rm, Rn, Rt, Ru, Rv, Rw, Rx, Ry, and Rz are independently hydrogen or substituted or unsubstituted alkyl. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36)
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Specification