System and Method for Determining Arterial Compliance and Stiffness

• US 20160302672A1
• Filed: 06/28/2016
• Published: 10/20/2016
• Est. Priority Date: 08/04/2014
• Status: Abandoned Application

• Current Assignee: Yamil Kuri
• Original Assignee: Yamil Kuri
• Inventors: Kuri, Yamil
• Application Number:
  US15/194,656
• Publication Number:
  US 20160302672A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/02028 Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/022 by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
• CPC Class Codes: A61B 5/024 Detecting, measuring or recording pulse rate or heart rate A61B5/0205, A61B5/021 take precedence
• CPC Class Codes: A61B 5/0261 using optical means, e.g. infrared light
• CPC Class Codes: A61B 5/0285 Measuring or recording phase velocity of blood waves
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 5/7278 Artificial waveform generation or derivation, e.g. synthesising signals from measured signals A61B5/327 takes precedence
• CPC Class Codes: A61B 8/04 Measuring blood pressure
• CPC Class Codes: A61B 8/06 Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00
• CPC Class Codes: A61B 8/0891 for diagnosis of blood vessels
• CPC Class Codes: A61B 8/488 involving Doppler signals
• CPC Class Codes: A61B 8/5223 for extracting a diagnostic or physiological parameter from medical diagnostic data for algorithms to analyse biomedical images G06T7/0012
• CPC Class Codes: G16H 50/30 for calculating health indices; for individual health risk assessment

Abstract

A system and method for calculating the arterial compliance, stiffness, and arterial flow and resistance indices for any artery in issue of a subject having a blood pressure monitoring device configured to calculate systolic and diastolic blood pressure readings for an artery of the subject, a blood flow velocity monitoring device configured to calculate the velocity of blood flowing within the artery of the subject at a peak point of a systolic phase of contraction of the subject'"'"'s heart muscle, peak-systolic velocity, and the velocity of blood flowing within the artery of the subject at an end point of a diastolic phase of the subject'"'"'s heart muscle, end-diastolic velocity, and a central processing unit comprising a computer readable program embodied within the central processing unit configured to calculate the arterial compliance, stiffness, and arterial flow and resistance indices as a function of the area of the artery under initial systolic and end diastolic pressure, the area of the artery generating arterial elastic recoil pressure for continuous flow during the systolic and diastolic phases, peak-systolic and end-diastolic arterial flow velocities, and systolic and diastolic blood pressure.

Claims

1. A system for calculating an arterial compliance index for determining the arterial stiffness of an artery of a subject, wherein the system does not excite the artery to induce a perturbation in the artery, the system comprising:

a blood pressure monitoring device configured to measure a systolic blood pressure reading and a diastolic blood pressure reading for the artery of the subject;

a blood flow velocity monitoring device configured to measure a peak-systolic blood flow velocity, wherein the peak-systolic blood flow velocity is a first measure of velocity of blood flowing within the artery of the subject at a peak point of a systolic phase of contraction of the subject'"'"'s heart muscle, and an end-diastolic blood flow velocity, wherein the end-diastolic blood flow velocity is a second measure of velocity of blood flowing within the artery of the subject at an end point of a diastolic phase of relaxation of the subject'"'"'s heart muscle; and

a central processing unit configured to calculate the arterial compliance index as a function of the subject'"'"'s;

(a) systolic blood pressure reading as measured by the blood pressure monitoring device;

(b) diastolic blood pressure reading as measured by the blood pressure monitoring device;

(c) peak-systolic blood flow velocity determined during the systolic phase of contraction of the subject'"'"'s heart muscle; and

(d) end-diastolic blood flow velocity determined during a period of relaxation of the subject'"'"'s heart muscle.

2. The system of claim 1, wherein the blood flow monitoring device utilizes a light source, whereby the light source is an optical transmitter that is paired with an optical receiver, wherein both of the optical transmitter and the optical receiver are connected to one or more electrically based devices or systems.

3. The system of claim 1, wherein the system is incorporated in a device that may be worn on the subject.

4. The system of claim 1, wherein a first ultrasound beam is directed towards a periphery of the subject most distal to the subject'"'"'s heart to further determine the peak-systolic blood flow velocity and end diastolic blood flow velocity.

5. The system of claim 1, wherein a second ultrasound beam is directed towards a periphery of the subject most proximate to the subject'"'"'s heart to further determine the peak-systolic blood flow velocity and end diastolic blood flow velocity.

6. The system of claim 4, wherein a first angle of the first ultrasound beam is measured with respect to a horizontal axis of the artery.

7. The system of claim 5, wherein a second angle of the second ultrasound beam is measured with respect to a horizontal axis of the artery.

8. The system of claim 7, wherein the second angle of the ultrasound beam is substantially equal to the first angle of the ultrasound beam.

9. The system of claim 1, wherein a first plurality of ultrasound beams are directed towards a periphery of the subject most distal to the subject'"'"'s heart at a first set of varying angles.

10. The system of claim 9, wherein a second plurality of ultrasound beams are directed towards a periphery of the subject most proximate to the subject'"'"'s heart at a second set of varying angles.

11. The system of claim 10, wherein a first set of arterial compliance index values derived from the first plurality of ultrasound beams directed towards a periphery of the subject most distal to the subject'"'"'s heart is compared with a second set of arterial compliance index values derived from the second plurality of ultrasound beams directed towards a periphery of the subject most proximate to the subject'"'"'s heart, and wherein an angle common to the first set of varying angles and the second set of varying angles is selected, wherein the angle selected produces a first arterial compliance index value within the first set of arterial compliance index values that most closely corresponds with a second arterial compliance index value within the second set of arterial compliance index values.

12. A system for calculating an arterial compliance index for determining the arterial stiffness of an artery of a subject, wherein the system does not excite the artery to induce a perturbation in the artery, the system comprising:

a blood pressure monitoring device configured to measure a systolic blood pressure reading and a diastolic blood pressure reading for the artery of the subject;

a device for measuring a first diameter of the artery at a peak systolic pressure and a second diameter of the artery at a peak diastolic pressure;

a central processing unit configured to calculate the arterial compliance index as a function of the subject'"'"'s;

(a) systolic blood pressure reading as measured by the blood pressure monitoring device;

(b) diastolic blood pressure reading as measured by the blood pressure monitoring device;

(c) the first diameter of the artery determined at a peak systolic phase of contraction of the subject'"'"'s heart muscle as measured by the device; and

(d) the second diameter of the artery determined at a peak diastolic phase of relaxation of the subject'"'"'s heart muscle as measured by the device.

13. The system of claim 12, wherein the central processing unit is configured to calculate the arterial compliance index as a further function of a quotient determined by a proportion of a first part, wherein the first part is a peak systolic blood pressure reading and a second part, wherein the second part is determined by a ratio of the first diameter of the artery determined at a peak systolic phase of contraction of the subject'"'"'s heart muscle to the second diameter of the artery determined at a peak diastolic phase of relaxation of the subject'"'"'s heart muscle as measured by the device, and wherein the ratio is a square function.

14. A system for calculating an arterial compliance index for determining the arterial stiffness of an artery of a subject, wherein the system does not excite the artery to induce a perturbation in the artery, the system comprising:

a blood pressure monitoring device configured to measure a systolic blood pressure reading and a diastolic blood pressure reading for the artery of the subject;

a device for measuring a first area of the artery at a peak systolic pressure and a second area of the artery at a peak diastolic pressure;

a central processing unit configured to calculate the arterial compliance index as a function of the subject'"'"'s;

(a) systolic blood pressure reading as measured by the blood pressure monitoring device;

(b) diastolic blood pressure reading as measured by the blood pressure monitoring device;

(c) the first area of the artery determined at a peak systolic phase of contraction of the subject'"'"'s heart muscle as measured by the device; and

(d) the second area of the artery determined at a peak diastolic phase of relaxation of the subject'"'"'s heart muscle as measured by the device.

15. The system of claim 14, wherein the central processing unit is configured to calculate the arterial compliance index as a further function of a quotient, wherein the quotient is determined by a proportion of a first part, wherein the first part is a peak systolic blood pressure reading and a second part, wherein the second part is determined by a ratio of the first area of the artery determined at a peak systolic phase of contraction of the subject'"'"'s heart muscle and the second area of the artery determined at a peak diastolic phase of relaxation of the subject'"'"'s heart muscle as measured by the device.

16. A system for calculating an arterial compliance index for determining the arterial stiffness of the ascending aorta artery of a subject, wherein the system does not excite the artery to induce a perturbation in the artery, the system comprising:

a blood pressure monitoring device configured to measure a systolic blood pressure reading and a diastolic blood pressure reading for the artery of the subject;

a device for measuring a systole time, wherein the systole time is defined as a time during which the left ventricle of the heart of the subject is contracting and for measuring a diastole time, wherein the diastole time is defined as a time during which the left ventricle of the heart of the subject is relaxing;

a heart rate measuring device for determining the heart rate of the subject; and

a central processing unit configured to calculate the arterial compliance index as a function of the subject'"'"'s;

(a) systolic blood pressure reading as measured by the blood pressure monitoring device;

(b) diastolic blood pressure reading as measured by the blood pressure monitoring device;

(c) the heart rate;

(d) the systole time; and

(e) the diastole time.

17. The system of claim 16, wherein the arterial compliance index of the ascending aorta artery substantially corresponds to mean arterial pressure.

18. The system of claim 16, wherein the arterial compliance index is a function of a product of the pulse pressure and a quotient determined by a first part, wherein the first part is the diastole time and a second part, wherein the second part is a sum of the diastole time and systole time.

19. The system of claim 16, wherein the arterial compliance index is a function of a product of the pulse pressure and a quotient determined by a first part, wherein the first part is the systole time and a second part, wherein the second part is a sum of the diastole time and systole time.

20. The system of claim 18, wherein the arterial compliance index is determined by subtracting from the systolic pressure a product of the pulse pressure and a quotient determined by a first part, wherein the first part is the diastole time and a second part, wherein the second part is a sum of the diastole time and systole time.

21. The system of claim 19, wherein the arterial compliance index is determined by adding to the diastolic pressure a product of the pulse pressure and a quotient determined by a first part, wherein the first part is the systole time and a second part, wherein the second part is a sum of the diastole time and systole time.

22. The system of claim 16, wherein the arterial compliance index is a further function of a subject'"'"'s heart rate.

23. The system of claim 22, wherein the arterial compliance index is a function of a first product of the pulse pressure and a second product of the diastole time and the subject'"'"'s heart rate per second.

24. The system of claim 22, wherein the arterial compliance index is a function of a first product of the pulse pressure and a second product of the systole time and the subject'"'"'s heart rate per second.

25. The system of claim 23, wherein the arterial compliance index is determined by subtracting from the systolic pressure a first product of the pulse pressure and a second product of the diastole time and the subject'"'"'s heart rate per second.

26. The system of claim 24, wherein the arterial compliance index is determined by adding the diastolic pressure to a first product of the pulse pressure and a second product of the systole time and the subject'"'"'s heart rate per second.

27. The system of claim 16, wherein the arterial compliance index is a further function of a first area of the ascending aorta artery and a second area of the subject'"'"'s aortic valve.

28. The system of claim 16, wherein the arterial compliance index is a quotient determined by a first part and a second part, wherein the first part is determined by a sum of a first product of the diastolic pressure and the diastole time and a second product of the systolic pressure and the systole time, and wherein the second part is determined by a sum of the diastole time and the systole time.

29. The system of claim 27, wherein the arterial compliance index is a quotient determined by a first part and a second part, wherein the first part is determined by a sum of a first product of the diastolic pressure and the area of the ascending aorta artery and a second product of systolic pressure of the left ventricle and the area of the aortic valve, and wherein the second part is determined by a sum of the area of the ascending aorta artery and the area of the aortic valve.

30. The system of claim 29, wherein the systolic blood pressure of the left ventricle is substantially equal to the systolic pressure of the ascending aorta artery, wherein there is substantially no gradient across the aortic valve.