CROSS-LINKED PEG POLYMER COATING FOR IMPROVING BIOCOMPATIBILITY OF MEDICAL DEVICES

• US 20160302723A1
• Filed: 12/04/2014
• Published: 10/20/2016
• Est. Priority Date: 12/04/2013
• Status: Abandoned Application

• Current Assignee: Medical Surface Inc.
• Original Assignee: Medical Surface Inc.
• Inventors: Chen, Xiaoxi Kevin
• Application Number:
  US15/100,439
• Publication Number:
  US 20160302723A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61B 2562/18 Shielding or protection of sensors from environmental influences, e.g. protection from mechanical damage
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14735 comprising an immobilised reagent
• CPC Class Codes: A61B 5/1486 using enzyme electrodes, e.g. with immobilised oxidase
• CPC Class Codes: A61B 5/6801 specially adapted to be attached to or worn on the body surface
• CPC Class Codes: A61B 5/686 Permanently implanted devices, e.g. pacemakers, other stimulators, biochips A61B5/6861 takes precedence
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: A61M 2205/0238 the material being a coating or protective layer
• CPC Class Codes: B05D 1/62 Plasma-deposition of organic layers plasma deposition in general C23C14/00, C23C16/00
• CPC Class Codes: B05D 5/04 to obtain a surface receptive to ink or other liquid B05D5/02, B41M5/52 take precedence

Abstract

The present invention relates to a cross-linked PEG polymer coating that is hydrophilic, lubricious, and resistant to adsorption of biological matters including proteins and cells. The coating is created using plasma glow discharge polymerization of organic compounds with a formula R(OCH₂CH₂)_nOH, where R is an alkane group with 1-4 carbon atoms and n=1-6.

Claims

1. A device comprising a substrate and a coating composition, said coating composition being produced by, i) providing a monomer source comprising one or more chemical compounds, wherein at least one chemical compound is R(OCH₂CH₂)_nOH, where R is an alkane group with 1-4 carbon atoms and n=1-6;

ii) creating a plasma of the monomer source; and

iii) contacting at least a portion of a substrate with the plasma to provide a plasma polymer coated surface wherein the plasma polymer coated surface is hydrophilic, lubricious, and has the characteristics of resisting protein adsorption and cell adhesion.

2. A device of claim 1, wherein the substrate is a medical implant or a wearable medical device.

3. A device of claim 1, wherein the substrate is an implantable or wearable biosensor.

4. A device of claim 1, wherein the substrate is a glucose monitoring device.

5. A device of claim 1, wherein the substrate is a dialysis membrane.

6. A device of claim 1, wherein the substrate is a hemodialysis device.

7. A device of claim 1, wherein the substrate is a contact lens.

8. The method of claim 1, wherein said chemical compound is selected from one or a mixture of the following:

Tri(ethylene glycol) monoethyl ether (CH₃CH₂(OCH₂CH₂)₃OH) and Tri(ethylene glycol) monomethyl ether (CH₃(OCH₂CH₂)₃OH).