BENZENESULFONAMIDE DERIVATIVES OF QUINOXALINE, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR USE IN METHODS FOR TREATING CANCER
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Abstract
Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of using these chemical entities, e.g., for treatment of cancer are described.
13 Citations
74 Claims
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1-46. -46. (canceled)
- 47. A method of treating a disorder mediated by Raf in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a compound or pharmaceutically acceptable salt of an Formula I:
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48. A method of treating a disorder in a subject in need thereof, comprising:
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a. determining the presence or absence of a BRAF mutation in a biological sample isolated from the subject; and b. if a BRAF mutation is determined to be present in the subject, administering to the subject a therapeutically effective amount of a compound or pharmaceutically acceptable salt of Formula I; - View Dependent Claims (49, 50, 51, 52, 53, 54, 63, 64, 65, 66, 67)
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55-62. -62. (canceled)
Specification