COMPOUNDING DEVICE, SYSTEM, KIT, SOFTWARE, AND METHOD

• US 20160310362A1
• Filed: 04/23/2015
• Published: 10/27/2016
• Est. Priority Date: 04/23/2015
• Status: Active Grant

• Current Assignee: B Braun Medical Incorporated (B. Braun Holding GmbH & Co. KG)
• Original Assignee: B Braun Medical Incorporated (B. Braun Holding GmbH & Co. KG)
• Inventors: Lane, Benjamin R., Mumpower, Mariano, Cowperthwaite, Jake A., Kendall, Jamie, Savage, Jeremy C., Larrow, Chet B., Flamm, Alex K., Hershey, Dave E., Bartholomew, Joel, Burnard, Edwin, Pearl, Aaron S., Brown, Michael Y., Konrad, Karl Jr., Janders, Mike
• Granted Patent: US 11,357,966 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61J 2200/70 Device provided with specific sensor or indicating means
• CPC Class Codes: A61J 3/002 Compounding apparatus specially for enteral or parenteral nutritive solutions bottling liquids B67C
• CPC Class Codes: A61M 2039/229 Stopcocks
• CPC Class Codes: A61M 39/22 Valves or arrangement of valves A61M39/02, A61M39/0247, A61M39/16 take precedence; regulating valves in infusion systems A61M5/16881; in devices worn by the patient for the reception of urine, faeces, catamenial or other discharge, or in colostomy devices A61F5/4405
• CPC Class Codes: A61M 39/223 Multiway valves
• CPC Class Codes: A61M 39/24 Check- or non-return valves
• CPC Class Codes: B01F 2101/06 Mixing of food ingredients
• CPC Class Codes: B01F 2101/22 Mixing of ingredients for pharmaceutical or medical compositions
• CPC Class Codes: B01F 2101/2202 Mixing compositions or mixers in the medical or veterinary field
• CPC Class Codes: B01F 2101/2204 Mixing chemical components in generals in order to improve chemical treatment or reactions, independently from the specific application
• CPC Class Codes: B01F 23/45 using flow mixing
• CPC Class Codes: B01F 23/451 by injecting one liquid into another
• CPC Class Codes: B01F 25/1051 of the mixing valve type
• CPC Class Codes: B01F 25/30 Injector mixers mixing by creating vortex flow B01F25/10
• CPC Class Codes: B01F 25/31 in conduits or tubes through which the main component flows
• CPC Class Codes: B01F 33/30 Micromixers
• CPC Class Codes: B01F 33/3017 Mixing chamber
• CPC Class Codes: B01F 33/84 Mixing plants with mixing receptacles receiving material dispensed from several component receptacles, e.g. paint tins
• CPC Class Codes: B01F 33/846 using stored recipes for determining the composition of the mixture to be produced, i.e. for determining the amounts of the basic components to be dispensed from the component receptacles
• CPC Class Codes: B01F 35/7176 using pumps
• CPC Class Codes: B01F 35/717611 : Peristaltic pumps
• CPC Class Codes: B01F 35/71805 : using valves, gates, orifices or openings
• CPC Class Codes: B65B 3/12 : mechanically, e.g. by pistons or pumps
• CPC Class Codes: F16K 11/085 : with cylindrical plug
• CPC Class Codes: F16K 11/0856 : having all the connecting conduits situated in more than one plane perpendicular to the axis of the plug
• CPC Class Codes: F16K 11/22 : with an actuating member for each valve, e.g. interconnected to form multiple-way valves
• CPC Class Codes: F16K 2099/0084 : Chemistry or biology, e.g. "lab-on-a-chip" technology
• CPC Class Codes: F16K 31/041 : for rotating valves F16K31/055 takes precedence
• CPC Class Codes: F16K 5/04 : with plugs having cylindrical surfaces; Packings therefor
• CPC Class Codes: F16K 5/0407 : with particular plug arrangements, e.g. particular shape or built-in means
• CPC Class Codes: F16K 5/0414 : Plug channel at 90 degrees to the inlet
• CPC Class Codes: F16K 99/0013 : Rotary valves
• CPC Class Codes: F16K 99/0042 : Electric operating means therefor

Abstract

An exemplary compounding system and method can include two pump heads for simultaneously drawing two different fluids from at least two separate input containers such that the at least two different fluids are mixed and distributed to an output container. The system can include a manifold that maintains separation of certain of the different fluids until after passing by a first pump and a second pump and/or additional pumps. A junction can be placed in the fluid line downstream of the first and second pumps and/or additional pumps such that all or some of the fluids are mixed prior to output to the output container. The method of using the system can include incorporating software that selects various fluids at certain times and sequences to ensure optimum efficiency and safety for the system, and can continue compounding actions even when an input supply container runs out or otherwise fails to supply a particular fluid/material. The method of use also includes connection of a transfer set to a housing in a manner that further ensures optimum efficiency and safety.

Claims

1. A compounding device for transferring materials from at least two distinct material sources to a final container, comprising:

a housing, the housing defining a valve surface and a pump surface;

at least one micro valve actuation device adjacent the valve surface;

at least one macro valve actuation device adjacent the valve surface;

a micro pump located adjacent the pump surface on the housing; and

a macro pump located adjacent the pump surface on the housing, wherein the micro valve actuation device operates with the micro pump to convey material from at least one of the material sources to the final container, and the macro valve actuation device operates with the macro pump to convey materials from at least another one of the material sources to the final container.

2. The compounding device of claim 1, further comprising:

a sensor bridge located on the housing and between the valve surface and the pump surface such that the micro pump and macro pump are separated from the micro valve actuation device and macro valve actuation device by the sensor bridge, the sensor bridge including a first throughway configured to house a micro input line, and a second throughway configured to house a macro input line.

3. The compounding device of claim 2, wherein the first throughway has a cross-section taken normal to a fluid pathway through the first throughway that is smaller than a cross-section of the second throughway taken normal to a fluid pathway through the second throughway.

4. The compounding device of claim 2, wherein the sensor bridge includes at least one bubble detection sensor configured to detect air bubbles located in material in at least one of the first throughway and second throughway.

5. The compounding device of claim 2, wherein the sensor bridge includes at least one occlusion detection sensor configured to detect an occlusion occurring in at least one of the first throughway and second throughway.

6. The compounding device of claim 1, wherein the micro pump includes a first rotor located adjacent a first platen, and the macro pump includes a second rotor located adjacent a second platen.

7. The compounding device of claim 6, wherein the first rotor and second rotor are interchangeable with each other.

8. The compounding device of claim 1, further comprising:

a controller configured to coordinate actuations of the micro valve actuation device and macro valve actuation device wherein actuations occur concurrently.

9. The compounding device of claim 8, wherein the controller is configured to control simultaneous flushing of a macro channel and a micro channel of the compounding device.

10. The compounding device of claim 1, wherein the at least one micro valve actuation device includes a plurality of micro valve actuation devices, and the at least one macro valve actuation device includes a plurality of macro valve actuation devices, and the plurality of micro valve actuation devices are configured to actuate in cooperation with actuation of the micro pump, and the plurality of macro valve actuation devices are configured to actuate in cooperation with actuation of the macro pump.

11. The compounding device of claim 10, wherein both the macro valve actuation devices and the micro valve actuation devices are configured to simultaneously open corresponding valves during simultaneous flushing of a macro channel and a micro channel of the compounding device.

12. The compounding device of claim 1, wherein the macro pump is configured to pump a first volume per second, and the micro pump is configured to pump a second volume per second, wherein the first volume per second is larger than the second volume per second.

13. The compounding device of claim 1, wherein each micro valve actuation device includes a first stepper motor, and each macro valve actuation device includes a second stepper motor.

14. The compounding device of claim 1, wherein the micro pump includes a micro pump stepper motor connected to a first rotor, and the macro pump includes a macro pump stepper motor connected to a second rotor.

15. The compounding device of claim 1, further comprising:

a transfer set including a manifold configured for attachment to the valve surface of the housing, and a plurality of transfer lines connecting corresponding material sources to the manifold.

16. A compounding device for mixing materials, comprising:

a first material source connected to a first valve actuation device;

a second material source connected to a second valve actuation device;

a third material source connected to a third valve actuation device;

a first line in fluid communication with an output of the first valve actuation device and extending to a micro pump;

a second line in fluid communication with an output of the second valve actuation device and an output of the third valve actuation device and extending to a macro pump;

a junction structure located downstream of both the micro pump and the macro pump and configured to join the first line with the second line such that material from the first material source is combined with material from the second material source and material from the third material source after passing the micro pump and the macro pump.

17. The compounding device of claim 16, further comprising:

a sensor bridge located between the first valve actuation device and the micro pump, and between the third valve actuation device and the macro pump, the sensor bridge including a first throughway configured to receive the first line, and a second throughway configured to receive the second line.

18. The compounding device of claim 17, wherein the first throughway has a cross-section taken normal to a fluid pathway through the first throughway that is smaller than a cross-section of the second throughway taken normal to a fluid pathway through the second throughway.

19. The compounding device of claim 17, wherein the sensor bridge includes at least one bubble detection sensor configured to detect air bubbles located in material in at least one of the first throughway and second throughway

20. The compounding device of claim 17, wherein the sensor bridge includes at least one occlusion detection sensor configured to detect an occlusion occurring in at least one of the first throughway and second throughway.

21. The compounding device of claim 16, wherein the micro pump includes a first rotor located adjacent a first platen, and the macro pump includes a second rotor located adjacent a second platen.

22. The compounding device of claim 21, wherein the first rotor and second rotor are interchangeable with each other.

23. The compounding device of claim 16, further comprising:

a controller configured to coordinate actuations of the first valve actuation device, second valve actuation device, third valve actuation device, micro pump, and macro pump wherein actuations occur concurrently.

24. The compounding device of claim 16, further comprising:

a controller configured to control simultaneous flushing of the first line and the second line.

25. The compounding device of claim 16, wherein the macro pump is configured to pump a first volume per second, and the micro pump is configured to pump a second volume per second, wherein the first volume per second is larger than the second volume per second.

26. The compounding device of claim 16, wherein each of the first valve actuation device, second valve actuation device and third valve actuation device includes a stepper motor.

27. The compounding device of claim 16, wherein the micro pump includes a micro pump stepper motor connected to a first rotor, and the macro pump includes a macro pump stepper motor connected to a second rotor.

28. The compounding device of claim 16, further comprising:

a transfer set including a manifold configured for attachment to the valve surface of the housing, and a plurality of transfer lines connecting corresponding material sources to the manifold.

29. The compounding device of claim 16, wherein the junction structure is a final container.

30. A method for compounding materials from a plurality of source containers into a final container, the method comprising:

providing a micro pump, a macro pump, a first material source including a first material, a second material source including a second material, a third material source including a third material, the final container, and a controller;

operating the micro pump via the controller to transfer the first material from the first material source to the final container;

operating the macro pump via the controller to transfer the second material from the second material source to the final container;

operating one of the micro pump and the macro pump via the controller to transfer the third material from the third material source to the final container; and

mixing the first material, second material, and third material at a location downstream of the micro pump and the macro pump.

31. The method for compounding materials of claim 30, further comprising:

providing a union junction located between the final container and both the micro pump and macro pump, wherein the mixing occurs at the union junction.

32. The method for compounding materials of claim 30, wherein operating the micro pump and operating the macro pump occurs simultaneously.

33. The method for compounding materials of claim 30, further comprising simultaneously ceasing operation of one of the micro pump and macro pump and continuing operation of the other of the micro pump and the macro pump.

34. The method for compounding materials of claim 30, further comprising:

providing a flex line from the third material source to both the macro pump and micro pump such that the macro pump and micro pump are both in fluid communication with the third material.