Intranasal Administration
3 Assignments
0 Petitions
Accused Products
Abstract
A delivery device for and method of modulating a condition relating to sodal cognition and/or behaviour in a human subject using oxytocin, non-peptide agonists thereof and/or antagonists thereof, comprising: providing a nosepiece to a first nasal cavity of the subject; and providing a supply unit for administering less than 24 IU of oxytocin, non-peptide agonists thereof and/or antagonists thereof through the nosepiece to an upper region posterior of the nasal valve which is innervated by the trigeminal nerve.
26 Citations
188 Claims
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1-71. -71. (canceled)
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72. A delivery device for modulating a condition in a human subject comprising:
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a mouthpiece configured to fit within an oral cavity of the subject and permit the subject to exhale therethrough, whereby exhalation by the subject causes closure of the oropharyngeal velum of the subject; a nosepiece fluidly connected to the mouthpiece, the nosepiece configured to fit within a nostril of the subject, wherein the device is configured to deliver an exhalation breath of the subject from the mouthpiece, through the nosepiece, and into a first nasal cavity of the subject; and a delivery unit containing oxytocin, the oxytocin comprising oxytocin, non-peptide agonists, and/or non-peptide antagonist thereof, the delivery unit configured to deliver the oxytocin through the nosepiece; wherein the oxytocin is delivered through the nosepiece to an upper posterior region, posterior of the nasal valve innervated by the trigeminal nerve. - View Dependent Claims (73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89)
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90. A delivery device for modulating a condition in a human subject comprising:
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a mouthpiece configured to fit within an oral cavity of the subject and permit the subject to exhale therethrough, whereby exhalation by the subject causes closure of the oropharyngeal velum of the subject; a nosepiece fluidly connected to the mouthpiece, the nosepiece having a longitudinal axis and configured to fit within a nostril of the subject, the nosepiece comprising a body having a base portion, a tip, and a projection extending from the base portion, wherein the tip is configured to extend into the nasal valve of the subject and expand the nasal valve, wherein the device is configured to deliver an exhalation breath of a subject from the mouthpiece, through the nosepiece, and into a first nasal cavity of the subject; and a delivery unit containing oxytocin, the oxytocin comprising oxytocin, non-peptide agonists, and/or non-peptide antagonist thereof, the delivery unit configured to deliver the oxytocin through the nosepiece; wherein the oxytocin is delivered through the nosepiece to an upper posterior region, posterior of the nasal valve innervated by the trigeminal nerve. - View Dependent Claims (91, 92, 93, 94, 95, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126)
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96. The delivery device of claim 96, wherein the oxytocin is delivered as a spray
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127. A method for modulating a condition in a human subject comprising:
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fitting a mouthpiece to an oral cavity of the subject; fitting a nosepiece fluidly connected to the mouthpiece to a nostril of the subject, the nosepiece having a longitudinal axis and comprising a body having a base portion, a tip, and a projection extending from the base portion, the tip configured to extend into the nasal valve of the subject and expand the nasal valve;
causing an exhalation breath of the subject to flow from the mouthpiece, through the nosepiece, and into a first nasal cavity of the subject;
wherein exhalation by the subject causes closure of the oropharyngeal velum of the subject; anddelivering oxytocin from a delivery unit through the nosepiece to an upper region posterior of the nasal valve innervated by the trigeminal nerve, the oxytocin comprising oxytocin, non-peptide agonists and/or antagonist thereof. - View Dependent Claims (128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159, 160, 161, 162, 163, 164, 165, 166, 167, 168, 169, 170, 171, 172, 173, 174, 175, 176, 177, 178, 179, 180, 181, 182, 183, 184, 185, 186, 187, 188)
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Specification