COMPOUNDING DEVICE, SYSTEM, KIT, SOFTWARE, AND METHOD

• US 20160310920A1
• Filed: 05/22/2015
• Published: 10/27/2016
• Est. Priority Date: 04/23/2015
• Status: Active Grant

• Current Assignee: B Braun Medical Incorporated (B. Braun Holding GmbH & Co. KG)
• Original Assignee: B Braun Medical Incorporated (B. Braun Holding GmbH & Co. KG)
• Inventors: Brown, Michael Y., Lane, Benjamin R., Mumpower, Mariano
• Granted Patent: US 10,143,985 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61J 2200/70 Device provided with specific sensor or indicating means
• CPC Class Codes: A61J 3/002 Compounding apparatus specially for enteral or parenteral nutritive solutions bottling liquids B67C
• CPC Class Codes: A61M 2039/229 Stopcocks
• CPC Class Codes: A61M 39/22 Valves or arrangement of valves A61M39/02, A61M39/0247, A61M39/16 take precedence; regulating valves in infusion systems A61M5/16881; in devices worn by the patient for the reception of urine, faeces, catamenial or other discharge, or in colostomy devices A61F5/4405
• CPC Class Codes: A61M 39/223 Multiway valves
• CPC Class Codes: A61M 39/24 Check- or non-return valves
• CPC Class Codes: B01F 2101/06 Mixing of food ingredients
• CPC Class Codes: B01F 2101/22 Mixing of ingredients for pharmaceutical or medical compositions
• CPC Class Codes: B01F 2101/2202 Mixing compositions or mixers in the medical or veterinary field
• CPC Class Codes: B01F 2101/2204 Mixing chemical components in generals in order to improve chemical treatment or reactions, independently from the specific application
• CPC Class Codes: B01F 23/45 using flow mixing
• CPC Class Codes: B01F 23/451 by injecting one liquid into another
• CPC Class Codes: B01F 25/1051 of the mixing valve type
• CPC Class Codes: B01F 25/30 Injector mixers mixing by creating vortex flow B01F25/10
• CPC Class Codes: B01F 25/31 in conduits or tubes through which the main component flows
• CPC Class Codes: B01F 33/30 Micromixers
• CPC Class Codes: B01F 33/3017 Mixing chamber
• CPC Class Codes: B01F 33/84 Mixing plants with mixing receptacles receiving material dispensed from several component receptacles, e.g. paint tins
• CPC Class Codes: B01F 33/846 using stored recipes for determining the composition of the mixture to be produced, i.e. for determining the amounts of the basic components to be dispensed from the component receptacles
• CPC Class Codes: B01F 35/7176 using pumps
• CPC Class Codes: B01F 35/717611 : Peristaltic pumps
• CPC Class Codes: B01F 35/71805 : using valves, gates, orifices or openings
• CPC Class Codes: B65B 3/12 : mechanically, e.g. by pistons or pumps
• CPC Class Codes: F16K 11/085 : with cylindrical plug
• CPC Class Codes: F16K 11/0856 : having all the connecting conduits situated in more than one plane perpendicular to the axis of the plug
• CPC Class Codes: F16K 11/22 : with an actuating member for each valve, e.g. interconnected to form multiple-way valves
• CPC Class Codes: F16K 2099/0084 : Chemistry or biology, e.g. "lab-on-a-chip" technology
• CPC Class Codes: F16K 31/041 : for rotating valves F16K31/055 takes precedence
• CPC Class Codes: F16K 5/04 : with plugs having cylindrical surfaces; Packings therefor
• CPC Class Codes: F16K 5/0407 : with particular plug arrangements, e.g. particular shape or built-in means
• CPC Class Codes: F16K 5/0414 : Plug channel at 90 degrees to the inlet
• CPC Class Codes: F16K 99/0013 : Rotary valves
• CPC Class Codes: F16K 99/0042 : Electric operating means therefor

Abstract

An exemplary compounding system and device for mixing materials from at least two distinct material sources can include a housing, a first fluid line operationally connected to the housing and configured to transport a first volume of fluid per unit time to a final container, a second fluid line operationally connected to the housing and configured to transport a second volume of fluid per unit time to the final container. The device can also include a pump system including, a first pump configured to move a first volume of fluid through a first fluid line, and a second pump configured to move a second volume of fluid through the second fluid line. The pump system can also be configured such that the volume of fluid per unit time delivered by the first and second pumps is different, and/or where the first and second pumps have different head characteristics.

Claims

1. A compounding device for mixing materials from at least two distinct material sources, comprising:

a housing;

a first fluid line operationally connected to the housing and configured to transport a first volume of fluid per unit time to a final container;

a second fluid line operationally connected to the housing and configured to transport a second volume of fluid per unit time to the final container, wherein the first volume of fluid per unit time is different from the second volume of fluid per unit time; and

a pump system including,

a first pump configured to move the first volume of fluid through the first fluid line, and

a second pump configured to move the second volume of fluid through the second fluid line.

2. The compounding device of claim 1, wherein the first pump is configured to have a first pump head characteristic, and the second pump is configured to have a second pump head characteristic, and the first pump head characteristic is different from the second pump head characteristic.

3. The compounding device of claim 1, wherein the first fluid line has a first cross-sectional flow area defined by a cross-section taken normal to a fluid pathway of the first fluid line, and the second fluid line has a second cross-sectional flow area defined by a cross-section taken normal to a fluid pathway of the second fluid line, wherein the first cross-sectional flow area is different from the second cross-sectional flow area.

4. The compounding device of claim 1, wherein the first pump includes a micro rotor and the second pump includes a macro rotor.

5. The compounding device of claim 4, wherein the first pump includes a micro stepper motor encoded for positional accuracy and connected to the micro rotor, and the second pump includes a macro stepper motor encoded for positional accuracy and connected to the macro rotor.

6. The compounding device of claim 5, wherein the micro rotor and macro rotor are interchangeable with each other, and the macro rotor is configured for connection to the micro stepper motor, and the micro rotor is configured for connection to the macro stepper motor.

7. The compounding device of claim 4, wherein the micro rotor includes a lower flange configured to support a first tube that comprises a portion of the first fluid line and the flange of the micro rotor configured to maintain the first tube in proper position with respect to the micro rotor and the housing, and the macro rotor includes a lower flange configured to support a second tube that comprises a portion of the second fluid line, and the flange of the macro rotor configured to maintain the second tube in proper position with respect to the macro rotor and the housing.

8. The compounding device of claim 4, further comprising:

a controller configured to rotate the micro rotor at a first speed and the macro rotor at a second speed, wherein the first speed is different from the second speed.

9. The compounding device of claim 1, further comprising:

a transfer set including at least a portion of both the first fluid line and the second fluid line;

at least three distinct material sources, each in fluid connection to the transfer set; and

a final container in fluid connection to at least one output port of the transfer set.

10. The compounding device of claim 1, further comprising:

a transfer set including at least a portion of both the first fluid line and the second fluid line, the transfer set including a manifold located upstream of both the first pump and second pump, the manifold including a micro channel that forms a portion of the first fluid line, and the manifold including a macro channel that forms a portion of the second fluid line, wherein the micro channel and the macro channel are in fluid isolation with respect to each other.

11. The compounding device of claim 10, wherein the micro channel includes a micro channel cross-sectional area defined by a cross-section taken normal to a fluid pathway through the micro channel, and the macro channel includes a macro channel cross-sectional area defined by a cross-section taken normal to a fluid pathway through the macro channel, wherein the micro channel cross-sectional area is smaller than the macro channel cross-sectional area.

12. The compounding device of claim 10, wherein the micro channel includes a plurality of input valves, each of the input valves of the micro channel is configured for connection to one of the distinct material sources, and the macro channel includes a plurality of input valves, each of the input valves of the macro channel is configured for connection to a different one of the distinct material sources.

13. The compounding device of claim 12, wherein at least one of the plurality of input valves in fluid connection with the micro channel is connected to a micro input tubing line, and at least one of the plurality of input valves in fluid connection with the macro channel is connected to a macro input tubing line, wherein a cross-sectional diameter of the micro input tubing line is smaller than a cross-sectional diameter of the macro input tubing line.

14. The compounding device of claim 13, wherein at least one of the plurality of input valves in fluid connection with the micro channel is connected to a macro input tubing line.

15. The compounding device of claim 10, wherein the macro channel of the manifold includes a macro exit port, and the micro channel of the manifold includes a micro exit port, and a cross-sectional diameter of the micro exit port is less than a cross-sectional diameter of the macro exit port.

16. The compounding device of claim 10, wherein the transfer set includes a micro tubing line extending from the micro channel of the manifold to the first pump, and the transfer set includes a macro tubing line extending from the macro channel of the manifold to the second pump, and a cross-sectional diameter of the micro tubing line is less than a cross-sectional diameter of the macro tubing line.

17. A compounding system for mixing materials from at least two distinct material sources, comprising:

a pump system including a first pump and a second pump; and

a transfer set configured to be connected to the pump system, wherein

the transfer set includes a first fluid line and a second fluid line, and the first fluid line is in fluid isolation from the second fluid line, and the first pump has a first volumetric flow rate and the second pump has a second volumetric flow rate, where the first volumetric flow rate is different from the second volumetric flow rate.

18. The compounding system of claim 17, wherein the transfer set includes a manifold configured for connection to the pump system, the manifold including a micro channel that forms a portion of the first fluid line and a macro channel that forms a portion of the second fluid line, wherein

the first fluid line includes a plurality of primary input lines in fluid communication with the micro channel, and the second fluid line includes a plurality of secondary input lines in fluid communication with the macro channel, and

the first fluid line includes a micro output line extending from the micro channel to the first pump to provide an output for the micro channel, and the second fluid line includes a macro output line extending from the macro channel to the second pump to provide an output for the macro channel.

19. The compounding system of claim 18, wherein the micro output line has a cross sectional area taken normal to a longitudinal axis of the micro output line that is less than a cross sectional area of the macro output line taken normal to a longitudinal axis of the macro output line.

20. The compounding system of claim 18, wherein the micro channel includes at least one micro input port, and the macro channel includes at least one macro input port, and the at least one micro input port has a first cross sectional area taken normal to a fluid flowpath of the micro input port, and the at least one macro input port has a second cross sectional area, and the first cross sectional area is less than the second cross sectional area taken normal to a fluid flowpath of the macro input port.

21. The compounding system of claim 20, wherein the micro channel further includes at least one macro input port, and a first material source of the at least two distinct material sources is connected and in fluid communication with both the at least one macro input port of the micro channel and the at least one micro input port of the micro channel.

22. The compounding system of claim 18, wherein the micro channel includes a micro output port, and the macro channel includes a macro output port, and the micro output port has a first cross sectional area taken normal to a fluid pathway of the micro output port, and the macro output port has a second cross sectional area taken normal to a fluid pathway of the macro output port, and the first cross sectional area is less than the second cross sectional area.

23. The compounding system of claim 18, wherein the micro output line extending from the micro channel to the first pump has a first cross sectional area taken normal to a fluid pathway of the micro output line, and the macro output line extending from the macro channel to the second pump has a second cross sectional area taken normal to a fluid pathway of the macro output line, and the first cross sectional area is different from the second cross sectional area.

24. The compounding system of claim 17, wherein the pump system is configured such that a first volume of fluid is removed from a first material source of the distinct material sources when the first pump is operated, and a second volume of fluid is removed from a second material source of the distinct material sources when the second pump is operated, and the second volume being different than the first volume.

25. The compounding system of claim 17, wherein the pump system is configured such that a first volume of fluid is removed from a first material source when the first pump is operated, and a second volume of fluid is removed from the first material source when the second pump is operated, and the second volume being different than the first volume.

26. The compounding system of claim 18, wherein an inner diameter of the micro channel is equal to an inner diameter of the macro channel.

27. The compounding system of claim 17, wherein the transfer set includes a manifold configured for connection to the pump system, the manifold including a micro channel that forms a portion of the first fluid line and a macro channel that forms a portion of the second fluid line, wherein the micro channel includes a micro input port and a macro input port, and a cross-section fluid flow area of the micro input port taken normal to a fluid pathway of the micro input port is different from a cross-section fluid flow area of the macro input port taken normal to a fluid pathway of the macro input port.

28. A compounding device for mixing materials from at least two distinct material sources, comprising:

a pump system including a first pump and a second pump, the pump system configured to selectively pump fluid from the at least two distinct material sources to a final container via a first fluid line and a second fluid line; and

a controller configured to control at least one of volume and speed of the fluid being pumped by the pump system, wherein

the controller is configured to cause the first pump to operate concurrently with the second pump and such that at least one of volume and speed of fluid being pumped via the first pump is different from a respective one of at least volume and speed of fluid being pumped via the second pump while the first pump and second pump are concurrently operated.

29. The compounding device of claim 28, wherein the first pump is a rotary pump, and the second pump is a rotary pump, and the first pump is configured to pump a first volume of fluid per unit time when rotating at a first speed, and the second pump is configured to pump a second volume of fluid per unit time when rotating at the first speed, and the first volume of fluid per unit time is different from the second volume of fluid per unit time.

30. The compounding device of claim 28, further comprising:

a transfer set including a portion of the first fluid line and a portion of the second fluid line, and the first fluid line is in fluid isolation from the second fluid line.

31. The compounding device of claim 28, wherein the first pump is configured to have a first head value and the second pump is configured to have a second head value, where the first head value is different from the second head value.

32. The compounding device of claim 28, wherein the first pump is a rotary pump including a plurality of rollers and at least one platen, and the controller is configured to correct output of the first pump based on a location of the rollers relative to the at least one platen.

33. The compounding device of claim 28, wherein the at least two distinct material sources includes a first material source, a second material source, and a third material source, and the controller is configured to cause fluid from the first material source and fluid from the second material source to mix upstream with respect to the first pump, and to cause fluid from the third material source to mix with the fluid from the first material source and fluid from the second material source at a location downstream with respect to the first pump.