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ANTI-PDL1 ANTIBODIES, ACTIVATABLE ANTI-PDL1 ANTIBODIES, AND METHODS OF USE THEREOF

  • US 20160311903A1
  • Filed: 03/14/2016
  • Published: 10/27/2016
  • Est. Priority Date: 03/13/2015
  • Status: Active Grant
First Claim
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1. An isolated antibody or antigen binding fragment thereof (AB) that specifically binds to mammalian PDL1, wherein the AB has one or more of the following characteristics:

  • (a) the AB specifically binds to human PDL1 and murine PDL1;

    (b) the AB specifically binds to human PDL1 and cynomolgus monkey PDL1;

    (c) the AB specifically binds to human PDL1, murine PDL1, and cynomolgus monkey PDL1;

    (d) the AB inhibits binding of human B7-1 and human PD1 to human PDL1 with an EC50 value less than 10 nM;

    (e) the AB inhibits binding of murine B7-1 and murine PD1 to murine PDL1 with an EC50 value less than 10 nM; and

    (f) the AB inhibits binding of cynomolgus monkey B7-1 and cynomolgus monkey PD1 to cynomolgus monkey PDL1 with an EC50 value less than 10 nM.

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