ISOXAZOLINE COMPOSITIONS AND USE THEREOF IN THE PREVENTION OR TREATMENT OF PARASITE INFESTATIONS IN ANIMALS

• US 20160317439A1
• Filed: 12/19/2014
• Published: 11/03/2016
• Est. Priority Date: 12/20/2013
• Status: Active Grant

• Current Assignee: Intervet Incorporated
• Original Assignee: Intervet Incorporated
• Inventors: Lehay, Anne, Flochlay-Sigognault, Annie
• Granted Patent: US 10,456,358 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A01N 25/02 containing liquids as carriers, diluents or solvents
• CPC Class Codes: A01N 43/80 five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
• CPC Class Codes: A23K 20/105 Aliphatic or alicyclic compounds
• CPC Class Codes: A23K 20/132 containing only one nitrogen as hetero atom
• CPC Class Codes: A23K 20/137 containing two hetero atoms, of which at least one is nitrogen
• CPC Class Codes: A23K 50/30 for swines
• CPC Class Codes: A23K 50/75 for poultry
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/42 Oxazoles
• CPC Class Codes: A61K 47/10 Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
• CPC Class Codes: A61K 47/14 Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
• CPC Class Codes: A61K 47/22 Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
• CPC Class Codes: A61K 47/26 Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• CPC Class Codes: A61K 9/0095 Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches A61K9/0007 takes precedence; eatable gels or foams A61K9/0056; oral mucosa adhesive forms A61K9/006
• CPC Class Codes: A61K 9/08 Solutions composition of solutions A61K47/00
• CPC Class Codes: A61K 9/107 Emulsions ; Emulsion preconcentrates; Micelles composition of emulsions A61K47/00
• CPC Class Codes: A61P 33/00 Antiparasitic agents
• CPC Class Codes: A61P 33/10 Anthelmintics
• CPC Class Codes: A61P 33/14 Ectoparasiticides, e.g. scabicides

Abstract

This invention is directed to a pharmaceutical composition for drinking water administration comprising isoxazoline compounds of formula (I) and a polysorbate surfactant and diethylene glycol monoethyl ether (transcutol); and the use of the composition to treat or prevent parasite infestations of animals.

Claims

1. A method of preventing or treating parasite infestations in animals by administering to such animal in its drinking water of a pharmaceutical composition comprising an isoxazoline compound of formula (I)

2. The method according to claim 1 wherein the isoxazoline compound is fluralaner.

3. The method according to claim 2 comprising between 1.5 mg/ml and 100 mg/ml of fluralaner.

4. The method according to claim 1 wherein the ratio of diethylene glycol monoethyl ether to polysorbate surfactant is <

50;

50% w/w.

5. The method according to claim 1 wherein the composition further comprises ethyl lactate.

8. The method according to claim 1 wherein the animals are selected from pigs and poultry.

9. The method according to claim 8 wherein the animals are laying hens.

10. The method according to claim 1 wherein the parasite infestation is a mite infestation.

11. The method according to claim 10 wherein the mite infestation is an infestation with Dermanyssus sp. or Ornithonyssus sp.

18. The method of claim 1, wherein n is 1, 2 or 3.

19. The method of claim 1, wherein R² is CF₃ or CF₂Cl.

20. The method of claim 1, wherein two adjacent radicals Y form together a three or four member chain.

6-7. -7. (canceled)

12. A Medicated drinking water comprising a mixture of a pharmaceutical composition comprising an isoxazoline compound of formula (I)

13. The Medicated drinking water according to claim 12 comprising between 0.001 and 1 mg/ml of the isoxazoline compound.

15. A Method for preparing medicated drinking water according to claim 12 wherein the pharmaceutical composition is diluted by injecting through a dosing pump system in a water system or by mixing with water in a medication tank.

16. The medicated drinking water according to claim 12 wherein the isoxazoline compound is fluralaner.

17. The medicated drinking water according to claim 12 wherein the composition further comprises ethyl lactate.

21. The medicated drinking water according to claim 12, wherein n is 1, 2 or 3.

22. The medicated drinking water according to claim 12, wherein R² is CF₃ or CF₂Cl.

23. The medicated drinking water according to claim 12, wherein two adjacent radicals Y form together a three or four member chain.

14. (canceled)