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MULTISPECIFIC DOMAIN EXCHANGED COMMON VARIABLE LIGHT CHAIN ANTIBODIES

  • US 20160319036A1
  • Filed: 04/07/2016
  • Published: 11/03/2016
  • Est. Priority Date: 10/11/2013
  • Status: Active Grant
First Claim
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1. A multispecific antibody, comprising:

  • a) two modified heavy chains;

    wherein each heavy chain comprises in C-terminal to N-terminal direction heavy chain constant domains 3, 2 and 1 (CH3, CH2 and CH1) and a light chain variable domain (VL), wherein the light chain variable domain (VL) is the variable domain of a common light chain;

    b) one modified light chain, wherein the modified light chain comprises in C-terminal to N-terminal direction a constant light chain domain (CL) of kappa isotype and a variable heavy chain domain (VH1) derived from an antibody, which specifically binds to a first antigen; and

    c) one modified light chain, wherein the modified light chain comprises in C-terminal to N-terminal direction a constant light chain domain of lambda isotype and a variable heavy chain domain (VH2) derived from an antibody, which specifically binds to a second antigen;

    wherein the variable domains VH1 and VL form a first antigen binding site which specifically binds to a first antigen, and wherein the variable domains VH2 and VL form a second antigen binding site which specifically binds to second antigen.

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