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ORGANOMIMETIC DEVICES AND METHODS OF USE AND MANUFACTURING THEREOF

  • US 20160326477A1
  • Filed: 12/19/2014
  • Published: 11/10/2016
  • Est. Priority Date: 12/20/2013
  • Status: Active Application
First Claim
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1. A device for simulating a function of a tissue, comprising:

  • a first microchannel;

    a second microchannel;

    a membrane located at an interface region between the first microchannel and the second microchannel, the membrane including a first side facing toward the first microchannel and a second side facing toward the second microchannel, the first side having cells of a first type thereon, the membrane separating the first microchannel from the second microchannel and permitting the migration of at least one of cells, particulates, chemicals, molecules, fluids and gases between the first side and the second side;

    a first wall portion coupled to the membrane; and

    a second wall portion, the membrane being fastened to the second wall portion such that the membrane is modulated by motion of at least one of the first wall portion and the second wall portion.

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