APPARATUS AND METHODS FOR MANIPULATION AND OPTIMIZATION OF BIOLOGICAL SYSTEMS

• US 20160326482A1
• Filed: 07/20/2016
• Published: 11/10/2016
• Est. Priority Date: 11/18/2004
• Status: Abandoned Application

• Current Assignee: Regents of the University of California (University of California)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: WONG, Pak Kin, HO, Chih-Ming, SUN, Ren, YU, Fuqu
• Application Number:
  US15/215,189
• Publication Number:
  US 20160326482A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: C12M 23/16 Microfluidic devices; Capillary tubes integrated microfluidic structures B01L3/5027; microreactors B01J19/0093
• CPC Class Codes: C12M 41/36 of biomass, e.g. colony counters or by turbidity measurements electrooptical investigation of individual particles G01N15/14, flow cytometers G01N15/1404
• CPC Class Codes: C12M 41/48 Automatic or computerized control automatic analysis G01N35/00
• CPC Class Codes: C12Q 1/02 involving viable microorganisms
• CPC Class Codes: C12Q 3/00 Condition responsive control processes apparatus therefor C12M1/36; controlling or regulating in general G05
• CPC Class Codes: G01N 2035/0094 optimisation; experiment design
• CPC Class Codes: G01N 35/0092 Scheduling
• CPC Class Codes: Y02A 90/10 Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

A system includes a processor and a memory storing processor-executable instructions, which when executed by the processor direct the processor to provide control data indicating application of a stimulus to a biological system, obtain sensor data indicating measurements of a response of the biological system to the stimulus, determine fitting parameters of a biological system model based on the response of the biological system to the stimulus, and predict a magnitude of the stimulus that, when applied to the biological system, will yield an optimized response of the biological system based on the model.

Claims

1. A system, comprising:

a processor; and

a memory storing processor-executable instructions, which when executed by the processor direct the processor to;

provide control data indicating application of a stimulus to a biological system;

obtain sensor data indicating measurements of a response of the biological system to the stimulus;

determine fitting parameters of a biological system model based on the response of the biological system to the stimulus; and

predict a magnitude of the stimulus that, when applied to the biological system, will yield an optimized response of the biological system based on the model.

2. The system of claim 1, the instructions further comprising instructions to direct the processor to:

determine, based on the model, predicted responses of applying varying magnitudes of the stimulus to the biological system;

obtain measured responses of the biological system to the varying magnitudes of the stimulus; and

determine ones of the fitting parameters by reducing deviations between the predicted responses and the measured responses.

3. The system of claim 1, the instructions further comprising instructions to direct the processor to:

determine a combination of stimuli to apply to the biological system based on the model; and

direct the combination of stimuli to be applied to the biological system.

4. The system of claim 3, wherein the combination of stimuli include one or more of biochemical, electromagnetic, thermal, mechanical, and optical stimulation.

5. The system of claim 3, wherein the combination of stimuli includes a combination of drugs.

6. The system of claim 1, the instructions further comprising instructions to direct the processor to:

determine a predicted response time of the biological system to the stimulus, based on the model.