IMPLANTABLE HUB AND SATELLITE SYSTEM FOR NEURAL RECORDING AND STIMULATION

• US 20160331973A1
• Filed: 05/13/2016
• Published: 11/17/2016
• Est. Priority Date: 05/15/2015
• Status: Abandoned Application

• Current Assignee: Charles Stark Draper Laboratory Incorporated, The General Hospital Corporation (Mass General Brigham, Inc.)
• Original Assignee: Charles Stark Draper Laboratory Incorporated, The General Hospital Corporation (Mass General Brigham, Inc.)
• Inventors: Wheeler, Jesse J., Parks, Philip D., Hamilton, Lei H., McConley, Marc W., Chin, Sang, Widge, Alik S., Dougherty, Darin D., Eskandar, Emad N., Moran, James E.
• Application Number:
  US15/154,487
• Publication Number:
  US 20160331973A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61B 5/383 Somatosensory stimuli, e.g. electric stimulation
• CPC Class Codes: A61B 5/4836 Diagnosis combined with treatment in closed-loop systems or methods A61B5/0036 takes precedence
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/36064 Epilepsy
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/36125 Details of circuitry or electric components
• CPC Class Codes: A61N 1/36139 with automatic adjustment
• CPC Class Codes: A61N 1/37217 characterised by the communication link, e.g. acoustic or tactile
• CPC Class Codes: A61N 1/37276 characterised by means for reducing power consumption during telemetry
• CPC Class Codes: H04B 1/385 Transceivers carried on the body, e.g. in helmets
• CPC Class Codes: H04L 41/0806 for initial configuration or provisioning, e.g. plug-and-play
• CPC Class Codes: H04L 43/16 Threshold monitoring
• CPC Class Codes: H04W 4/80 Services using short range communication, e.g. near-field communication [NFC], radio-frequency identification [RFID] or low energy communication

Abstract

The systems and methods described herein include an external base station with a tethered transceiver, an implanted hub that includes power, telemetry, and processing electronics, and a plurality of implanted satellite that contain reconfigurable front-end electronics for interfacing with electrodes. The system can operate in different modes. In a first mode, called a base boost mode, the external base station is used for closed-loop control of stimulation therapies. In a second, autonomous mode, closed-loop control is performed in the hub without direct influence from the base station. In a third mode, streams of neural data are transmitted to an offline processor for offline analysis.

Claims

1. A neural stimulation and recording system comprising:

a base station comprising;

a first low bandwidth transceiver; and

a high bandwidth receiver;

an implantable neural stimulation and recording hub comprising;

a second low bandwidth transceiver configured to wirelessly communicate with the first low bandwidth transceiver of the base station;

a high bandwidth transmitter configured to wirelessly transmit data to the high bandwidth receiver of the base station; and

a processor configured to;

receive, from the base station via the second low bandwidth transceiver, a configuration setting comprising template parameters;

transmit a first neural signal to the base station;

receive, from the base station via the second low bandwidth transceiver, a second configuration setting comprising updated template parameters generated responsive to the first neural signal;

detect a threshold crossing of a second neural signal received by the implantable neural stimulation and recording hub;

determine a neuropsychiatric state responsive to the threshold crossing of the second neural signal and the updated template parameters; and

generate an output stimulation command responsive to the determined neuropsychiatric state.

2. The system of claim 1, wherein the first and second low bandwidth transceivers have a bandwidth between about 1 Mbps and about 5 Mbps and the high bandwidth transmitter has a bandwidth between about 5 Mbps and about 50 Mbps.

3. The system of claim 1, wherein the first and second low bandwidth transceivers are low-energy Bluetooth®

transceivers.

4. The system of claim 1, wherein the processor is further configured to transmit the first neural signal, via the high bandwidth transmitter, to the high bandwidth receiver of the base station.

5. The system of claim 1, further comprising an offline processor coupled to the base station.

6. The system of claim 5, wherein the offline processor generates the configuration setting responsive to an initial neural signal transmitted from the implantable neural stimulation and recording hub.

7. The system of claim 1, further comprising a plurality of satellites coupled to the implantable neural stimulation and recording hub.

8. The system of claim 7, wherein each of the plurality of satellites comprise at least one electrode configured to measure the first and second neural signals.

9. The system of claim 7, wherein the plurality of satellites is configured to deliver an electrical stimulus responsive to the output stimulation command.

10. The system of claim 1, wherein the neuropsychiatric state is one of impulsivity, avoidance, inhibition, and an epileptic state.

11. A method comprising:

receiving, at an implantable neural stimulation and recording hub from a base station via a low bandwidth transceiver, a configuration setting comprising template parameters;

transmitting, from the implantable neural stimulation and recording hub, a first neural signal to the base station;

receiving, at the implantable neural stimulation and recording hub from the base station via the low bandwidth transceiver, a second configuration setting comprising updated template parameters generated response to the first neural signal;

detecting a threshold crossing of a second neural signal;

determining a neuropsychiatric state responsive to the threshold crossing of the first neural signal and the updated template parameters; and

generating an output stimulation command responsive to the determined neuropsychiatric state.

12. The method of claim 11, further comprising transmitting the first neural signal via a high bandwidth transmitter to a high bandwidth receiver of the base station.

13. The method of claim 12, wherein the low bandwidth transceiver has a bandwidth between about 1 Mbps and about 5 Mbps and the high bandwidth transmitter has a bandwidth between about 5 Mbps and about 50 Mbps.

14. The method of claim 11, wherein the low bandwidth transceiver is a low-energy Bluetooth®

transceiver.

15. The method of claim 11, further comprising transmitting an initial neural signal to an offline processor coupled to the base station.

16. The method of claim 15, further comprising generating, by the offline processor, the configuration setting responsive to the initial neural signal.

17. The method of claim 11, further comprising detecting the first neural signal by at least one of a plurality of satellites coupled to the implantable neural stimulation and recording hub.

18. The method of claim 11, further comprising extracting a plurality of features from the second neural signal and determining the neuropsychiatric state responsive to the plurality of features.

19. The method of claim 17, further comprising delivering, by at least one of the plurality of satellites, an electrical stimulus responsive to the output stimulation command.

20. The method of claim 11, wherein the neuropsychiatric state is one of impulsivity, avoidance, inhibition, and an epileptic state.