CHIRAL NUCLEIC ACID ADJUVANT HAVING IMMUNITY INDUCTION ACTIVITY, AND IMMUNITY INDUCTION ACTIVATOR
First Claim
1. An adjuvant for immunity-inducing activator,wherein the adjuvant comprises oligonucleotide which comprises two to four CpG motifs each represented by 5′
- -X1CpGX2-3′ and
has a length of 14 to 32 nucleotides,wherein the CpG is non-methylated CpG without modified phosphate backbones,wherein the X1 is A or T,wherein the X2 is A or T,wherein nucleic acids connected by phosphorothioate (PS) linkage are connected at 3′
end side of the at least two CpG motifs,wherein each of nucleic acids at 5′
end and 3′
end of the oligonucleotide is S type nucleic acid connected by phosphorothioate (PS) linkage, andwherein the oligonucleotide comprises at least one nucleic acid without phosphorothioate modification.
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Accused Products
Abstract
Problem
The purpose of the present invention is to provide: a chiral nucleic acid adjuvant having immunity-inducing activity and an immunity-inducing activator.
Solution
The present invention relates to an adjuvant which comprises oligonucleotides which comprise two to four sequences each represented by 5′-X1CpG X2-3′ and has a length of 14 to 32 nucleotides, wherein a nucleic acid at 3′ end side of at least two CpG motifs is connected by phosphorothioate linkage, wherein each nucleic acids at 3′ end and 5′ end of the oligonucleotide is S type nucleic acids connected by phosphorothioate linkage, and wherein the oligonucleotide comprises at least one nucleic acid without phosphorothioate modification. The present invention relates to an immunity-inducible activator comprising the adjuvant.
19 Citations
7 Claims
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1. An adjuvant for immunity-inducing activator,
wherein the adjuvant comprises oligonucleotide which comprises two to four CpG motifs each represented by 5′ - -X1CpGX2-3′ and
has a length of 14 to 32 nucleotides,wherein the CpG is non-methylated CpG without modified phosphate backbones, wherein the X1 is A or T, wherein the X2 is A or T, wherein nucleic acids connected by phosphorothioate (PS) linkage are connected at 3′
end side of the at least two CpG motifs,wherein each of nucleic acids at 5′
end and 3′
end of the oligonucleotide is S type nucleic acid connected by phosphorothioate (PS) linkage, andwherein the oligonucleotide comprises at least one nucleic acid without phosphorothioate modification. - View Dependent Claims (2, 3, 4, 5, 6, 7)
- -X1CpGX2-3′ and
Specification