DRUG DELIVERY DEVICES WITH DRUG-PERMEABLE COMPONENT AND METHODS
First Claim
Patent Images
1. A drug delivery device comprising:
- a housing having a closed drug reservoir lumen bounded by a first wall structure and a hydrophilic second wall structure; and
a drug contained in the drug reservoir lumen,wherein the first wall structure is impermeable to the drug, and the second wall structure is permeable to the drug, andwherein the first wall structure and the second wall structure are adjacent one another and together form a cylindrical tube.
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Abstract
Implantable drug delivery devices include a housing having a closed drug reservoir lumen bounded by a first wall structure and a hydrophilic second wall structure, and a drug contained in the drug reservoir lumen, wherein the first wall structure is impermeable to the drug and the second wall structure is permeable to the drug. Methods of providing controlled release of drug to a patient include deploying a drug delivery device in the patient releasing a drug from the drug reservoir lumen via diffusion through the second wall structure.
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Citations
21 Claims
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1. A drug delivery device comprising:
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a housing having a closed drug reservoir lumen bounded by a first wall structure and a hydrophilic second wall structure; and a drug contained in the drug reservoir lumen, wherein the first wall structure is impermeable to the drug, and the second wall structure is permeable to the drug, and wherein the first wall structure and the second wall structure are adjacent one another and together form a cylindrical tube. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A device for intravesical insertion and controlled release of a drug into the urinary bladder of a patient, the device comprising:
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a housing which comprises a first wall structure and a second wall structure which are adjacent one another and together form a cylindrical tube, wherein the first and second wall structures extend between opposed ends of the cylindrical tube and bound a closed drug reservoir lumen; and a drug in a solid or semisolid form contained in the drug reservoir lumen, wherein; the first wall structure is impermeable to the drug, the second wall structure is permeable to the drug, and the cylindrical tube is elastically deformable between a relatively straightened shape suited for insertion of the device through the urethra of the patient and into the bladder and a retention shape suited to retain the device within the bladder. - View Dependent Claims (13, 14, 15, 16)
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17. A method of providing controlled release of drug to a patient, comprising:
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deploying a drug delivery device in the patient, the device comprising a closed drug reservoir lumen bounded by a first wall structure and a hydrophilic second wall structure; and releasing a drug from the drug reservoir lumen via diffusion through the second wall structure, wherein the first wall structure is impermeable to the drug, and the second wall structure is permeable to the drug, and wherein the first wall structure and the second wall structure are adjacent one another and together form a cylindrical tube. - View Dependent Claims (18, 19, 20)
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21. A drug delivery device comprising:
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a housing having a closed drug reservoir lumen bounded by a first wall structure and a hydrophilic second wall structure, wherein the first and second wall structures comprise coextruded thermoplastic polymers; and a drug contained in the drug reservoir lumen, wherein the first wall structure is water permeable and impermeable to the drug, and the second wall structure is permeable to the drug, and wherein the first wall structure and the second wall structure are adjacent one another and together form an elongated tube.
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Specification