TREATMENT OF CANCER BY MANIPULATION OF COMMENSAL MICROFLORA
First Claim
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1. A method of treating cancer in a human subject comprising administering to the subject an immune checkpoint inhibitor and a bacterial formulation comprising bacteria of the genera Bifidobacterium.
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Abstract
Provided herein are methods of treatment and/or prevention of cancer by manipulation of commensal microflora. In particular, the amount, identity, presence, and/or ratio of microflora (e.g., gut microflora) in a subject is manipulated to facilitate one or more co-treatments.
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Citations
30 Claims
- 1. A method of treating cancer in a human subject comprising administering to the subject an immune checkpoint inhibitor and a bacterial formulation comprising bacteria of the genera Bifidobacterium.
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9. The method of claim 9, wherein the administration of the two or more doses are separated by at least 1 week.
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20. A method of treating cancer in a human subject comprising administering to the subject a bacterial formulation comprising at least 5×
- 106 CFU of bacteria of the genera Bifidobacterium, wherein at least 50% of the bacteria in the bacterial formulation are of the genera Bifidobacterium.
- View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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