POLYMERS

• US 20160361459A1
• Filed: 06/10/2016
• Published: 12/15/2016
• Est. Priority Date: 06/11/2015
• Status: Active Grant

• Current Assignee: Microvention Incorporated (Terumo Corporation)
• Original Assignee: Microvention Incorporated (Terumo Corporation)
• Inventors: Baldwin, Aaron
• Granted Patent: US 10,639,396 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61L 24/001 Use of materials characterised by their function or physical properties
• CPC Class Codes: A61L 24/0031 Hydrogels or hydrocolloids
• CPC Class Codes: A61L 24/06 obtained by reactions only involving carbon-to-carbon unsaturated bonds A61L24/043, A61L24/046 take precedence
• CPC Class Codes: A61L 2430/36 for embolization or occlusion, e.g. vaso-occlusive compositions or devices artificial blood vessels A61L27/507
• CPC Class Codes: A61L 31/14 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 31/145 Hydrogels or hydrocolloids
• CPC Class Codes: A61L 31/18 Materials at least partially X-ray or laser opaque

Abstract

Described herein are polymers and associated methods to occlude structures and malformations of the vasculature with polymers with delayed controlled rates of expansion. Methods of forming such devices are also disclosed.

Claims

1. An expansile device for implantation comprising:

an expansile polymer including a reaction product of a polymerization solution including a macromer, a monomer, a first crosslinker, and a second cleavable crosslinker,

wherein the second cleavable crosslinker imparts a secondary expansion to the expansile polymer.

2. The expansile device of claim 1, wherein the expansile device includes no support members.

3. The expansile device of claim 1 further including at least one visualization element.

4. The expansile device according to claim 3, wherein the at least one visualization element is selected from metallic powders, gadolinium, superparamagnetic iron oxide particles, or a combination thereof.

5. The expansile device according to claim 3, wherein the at least one visualization element is barium sulfate.

6. The expansile device according to claim 1, wherein the monomer is pH sensitive and provides a first expansion to the expansile polymer.

7. The expansile device according to claim 1, wherein the second cleavable crosslinker is an acrylate based crosslinker.

8. The expansile device according to claim 7, wherein the acrylate based crosslinker is an acrylic anhydride based crosslinker.

9. The expansile device according to claim 8, wherein the acrylic anhydride based crosslinker has a structure

10. The expansile device according to claim 8, wherein the methacrylate based anhydride crosslinker is synthesized by reaction of a di-acid with methacrylic anhydride.

11. A method of forming an expansile polymer comprising:

polmyerizing a polymer from a polymerization solution comprising a macromer, a monomer, a first crosslinker, and a second cleavable crosslinker,

wherein the second cleavable crosslinker imparts a secondary expansion to the expansile polymer.

12. The method of claim 11 further comprising treating said polymer in a non-physiological pH for a predetermined amount of time thereby creating an environmentally responsive hydrogel.

13. The method of claim 12, wherein the non-physiological pH is acidic.

14. The method of claim 12, wherein the non-physiological pH is basic.

15. The method of claim 12 further including at least one visualization element.

16. The method of claim 15, wherein the at least one visualization element is a metallic powder, gadolinium, superparamagnetic iron oxide particles, barium sulfate, or a combination thereof.

17. The method of claim 12, wherein the second cleavable crosslinker is an acrylic anhydride based crosslinker.

18. The method of claim 17, wherein the acrylic anhydride crosslinker has a structure

19. The method of claim 17, wherein the acrylic anhydride crosslinker is synthesized by reaction of a di-acid with methacrylic anhydride.

20. The method of claim 12, wherein the first crosslinker is N,N′

-methylenebisacrylamide.