LIGHT-BASED DRUG DISPENSING SYSTEM TO SIMULATE THE OPERATION OF A HUMAN PANCREAS

• US 20160361561A1
• Filed: 08/25/2016
• Published: 12/15/2016
• Est. Priority Date: 05/29/2015
• Status: Abandoned Application

• Current Assignee: Midwest Business Associates, Inc.
• Original Assignee: Midwest Business Associates, Inc.
• Inventors: Madugula, Rama, Sabharwal, Anup, Majeti, Sankar, Madugula, Murty
• Application Number:
  US15/247,796
• Publication Number:
  US 20160361561A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61K 31/64 Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61M 2205/18 with alarm
• CPC Class Codes: A61M 2205/3584 using modem, internet or bluetooth
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: A61M 2205/583 by visual feedback
• CPC Class Codes: A61M 5/14 Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
• CPC Class Codes: A61N 2005/0626 Monitoring, verifying, controlling systems and methods
• CPC Class Codes: A61N 2005/0652 Arrays of diodes
• CPC Class Codes: A61N 2005/0663 Coloured light
• CPC Class Codes: A61N 5/062 Photodynamic therapy, i.e. excitation of an agent
• CPC Class Codes: G08B 21/0453 worn on the body to detect health condition by physiological monitoring, e.g. electrocardiogram, temperature, breathing detecting, measuring or recording for diagnostic purposes A61B5/00
• CPC Class Codes: G16H 20/10 relating to drugs or medications, e.g. for ensuring correct administration to patients
• CPC Class Codes: G16H 20/13 delivered from dispensers
• CPC Class Codes: G16H 40/67 for remote operation

Abstract

Disclosed is a light-based system for dispensing drug formulations that simulates the operation of a human pancreas. Drug formulations dispensable by the system contain at least one synthetic molecular switch compound whose structure and dosage amounts are controllable by light energy and based on both light wavelength and light intensity. The system dispenses drug formulations based on light generated by a set of LED arrays that includes blue LED'"'"'s; the light is detected by photoreceivers within a drug depot matrix port that contains the drug formulations. The system is designed such that multiple drug formulations used simultaneously are each controlled by a separate LED array and by separate photoreceivers operating at separate wavelengths such that the drug formulations, LED arrays, photoreceivers and wavelengths do not interfere with each other.

Claims

1. A light-based system for dispensing drug formulations that simulates the operation of a human pancreas, comprising:

at least one drug formulation containing at least one synthetic molecular switch compound whose structure and dosage amounts are controllable by light energy and based on both light wavelength and light intensity;

a drug depot matrix port that holds said drug formulation and includes at least one set of photoreceivers that detects light from at least one set of LED arrays;

at least one set of LED arrays that generates at least one light beam of a wavelength and intensity that controls the dosage of said drug formulation given to said patient;

at least one sensor to monitor the physical condition of said light-based system;

at least one sensor to monitor the physical condition of said patient; and

,

a computer program that monitors the amount of said drug formulation in said drug depot matrix port, controls the amount of said drug formulation given to said patient, monitors the amount of light detected by said photoreceivers, monitors the operating temperature and controls the operation of said LED arrays, monitors information received from said sensors, generates and sends alerts to problems detected with said patient, and generates and sends alerts to problems detected within said light-based system.

2. The light-based system of claim 1, wherein said drug formulation is given to said patient either orally or through said drug depot matrix port.

3. The light-based system of claim 1, wherein said drug formulation is a sulfonylurea compound, a diabetes drug formulation, insulin, or an anti-inflammatory compound.

4. The light-based system of claim 3, wherein said sulfonylurea compound is JB253.

5. The light-based system of claim 1, wherein said drug depot matrix port is located outside the body of said patient, is a subcutaneous drug reservoir within the body of said patient, or is an intramuscular drug reservoir within the body of said patient.

6. The light-based system of claim 1, wherein said computer program may control said set of LED arrays by setting the pulse width modulation duty cycle or by setting the maximum amount of LED activation within a given time period.

7. The light-based system of claim 1, wherein said set of LED arrays is located inside the body of said patient or outside the body of said patient.

8. The light-based system of claim 1, wherein said set of LED arrays contain LED'"'"'s that are blue in color.

9. The light-based system of claim 1, wherein multiple drug formulations used simultaneously within said drug depot matrix port are each controlled by a separate LED array and by separate photoreceivers operating at separate wavelengths such that said drug formulations, said LED arrays, said photoreceivers and said wavelengths do not interfere with each other.

10. The light-based system of claim 1, wherein the alerts generated and sent for problems detected with said patient and the alerts generated and sent for problems detected within said light-based system include visual displays, auditory alarms, outputs to a message module, or wireless communications methods.

11. A method of dispensing drug formulations by using a light-based system to simulate the operation of a human pancreas, comprising:

ensuring that said drug formulation contains at least one synthetic molecular switch compound whose structure and dosage amounts are controllable by light energy and based on both light wavelength and light intensity;

loading at least one of said drug formulation into a drug depot matrix port that includes at least one set of photoreceivers that detects light from at least one set of LED arrays;

setting at least one set of said LED arrays to generate at least one light beam of a wavelength and intensity that controls the dosage of said drug formulation given to a patient;

monitoring of the physical condition of said light-based system;

monitoring of the physical condition of said patient; and

,

using a computer program to monitor the amount of said drug formulation in said drug depot matrix port, control the amount of said drug formulation given to said patient, monitor the amount of light detected by said photoreceivers, monitor the operating temperature and control the operation of said LED arrays, monitor information received from sensors used by said patient, generate and send alerts to problems detected with said patient, and generate and send alerts to problems detected within said light-based system.

12. The method of claim 11, wherein said drug formulation is given to said patient either orally or through said drug depot matrix port.

13. The method of claim 11, wherein said drug formulation is a sulfonylurea compound, a diabetes drug formulation, insulin, or an anti-inflammatory compound.

14. The light-based system of claim 13, wherein said sulfonylurea compound is JB253.

15. The method of claim 11, wherein said drug depot matrix port is located outside the body of said patient, is a subcutaneous drug reservoir within the body of said patient, or is an intramuscular drug reservoir within the body of said patient.

16. The method of claim 11, wherein said computer program may control said set of LED arrays by setting the pulse width modulation duty cycle or by setting the maximum amount of LED activation within a given time period.

17. The method of claim 11, wherein said set of LED arrays is located inside the body of said patient or outside the body of said patient.

18. The method of claim 11, wherein said set of LED arrays contain LED'"'"'s that are blue in color.

19. The method of claim 11, wherein multiple drug formulations used simultaneously within said drug depot matrix port are each controlled by a separate LED array and by separate photoreceivers operating at separate wavelengths such that said drug formulations, said LED arrays, said photoreceivers and said wavelengths do not interfere with each other.

20. The method of claim 11, wherein the alerts generated and sent for problems detected with said patient and the alerts generated and sent for problems detected within said light-based system include visual displays, auditory alarms, outputs to a message module, or wireless communications methods.