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METHODS AND COMPOSITIONS FOR THE TREATMENT OF PERSISTENT INFECTIONS AND CANCER BY INHIBITING THE PROGRAMMED CELL DEATH 1 (PD-1) PATHWAY

  • US 20160362492A1
  • Filed: 08/30/2016
  • Published: 12/15/2016
  • Est. Priority Date: 06/08/2005
  • Status: Active Grant
First Claim
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1. A method of increasing cytotoxic activity of anergic T cells in a subject having a lymphoproliferative cancer, comprisingadministering to the subject having the lymphoproliferative cancer an effective amount of an agent that reduces the activity of a Programmed Cell Death (PD)-1 polypeptide, wherein the agent is an anti-PD-1 antibody,thereby increasing the cytotoxic activity of anergic T cells in the subject with the lymphoproliferative cancer, wherein the lymphoproliferative cancer is a Hodgkin'"'"'s lymphoma.

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