APPARATUS FOR PERFORMING A SENSING APPLICATION

• US 20160363539A1
• Filed: 08/25/2016
• Published: 12/15/2016
• Est. Priority Date: 04/24/2012
• Status: Active Grant

• Current Assignee: Hewlett-Packard Development Company, L.P. (HP Inc.)
• Original Assignee: Hewlett-Packard Development Company, L.P. (HP Inc.)
• Inventors: Barcelo, Steven, Li, Zhiyong, Bratkovski, Alexandre M., Kim, Ansoon
• Granted Patent: US 9,778,198 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: B82Y 15/00 Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
• CPC Class Codes: G01N 21/658 enhancement Raman, e.g. surface plasmons
• CPC Class Codes: G01N 2201/06113 Coherent sources; lasers
• CPC Class Codes: Y10S 977/954 Of radiant energy

Abstract

An apparatus for performing a sensing application may a substrate having a plurality of nano-fingers positioned to receive the dispensed solution , first and second reservoirs, first and second dispensers to dispense first and second solutions from the first and second reservoirs onto first and second subsets of the plurality of nano-fingers. The plurality of nano-fingers are flexible, such that the plurality of nano-fingers are configurable with respect to each other. The apparatus may include an illumination source to illuminate the first and second solutions and an analyte introduced around the plurality of nano-fingers, wherein light is to be emitted from the analyte in response to being illuminated. The apparatus may include a detector to detect the light emitted from the analyte.

Claims

1. An apparatus for performing a sensing application, said apparatus comprising:

a reservoir to contain a solution;

a dispenser to dispense the solution from the reservoir;

a substrate having a plurality of nano-fingers positioned to receive the dispensed solution, wherein the plurality of nano-fingers are flexible, such that the plurality of nano-fingers are configurable with respect to each other;

an illumination source to illuminate the received solution, an analyte introduced around the plurality of nano-fingers, and the plurality of nano-fingers, wherein light is to be emitted from the analyte in response to being illuminated;

a detector to detect the light emitted from the analyte

a second reservoir to contain a second solution; and

a second dispenser to dispense the second solution from the reservoir onto a second subset of the plurality of nano-fingers that differs from a subset of the plurality of nano-fingers onto which the dispenser is to dispense the solution from the reservoir, wherein the illumination source is to further illuminate the dispensed second solution and wherein the detector is to detect light emitted from an analyte introduced around the second subset of the plurality of nano-fingers.

2. The apparatus according to claim 1, wherein the plurality of nano-fingers comprise respective tips, said apparatus further comprising:

Raman-active material nano-particles attached to respective tips of the plurality of nano-fingers.

3. The apparatus according to claim 2, wherein the plurality of nano-fingers are to be collapsed toward each other such that the Raman-active material nano-particles attached to the respective tips of subsets of the plurality of nano-fingers are brought into close proximity or in contact with each other.

4. The apparatus according to claim 1, wherein the dispenser is to dispense the solution onto a subset of the plurality of nano-fingers, and wherein the plurality of nano-fingers are positioned in sufficiently close proximity to each other to cause the subset of the plurality of nano-fingers to collapse toward each other as the solution evaporates through application of capillary forces onto the plurality of nano-fingers in the subset by the solution.

5. The apparatus according to claim 4, further comprising:

a heating element to increase the rate at which the solution evaporates.

6. The apparatus according to claim 4, wherein the illumination source is to apply heat to the solution on the subset of the plurality of nano-fingers to substantially enhance evaporation of the solution.

7. The apparatus according to claim 1, further comprising:

a movable stage; and

wherein the substrate is positioned on the movable stage, and wherein the movable stage is to be moved from a location to receive the solution from the dispenser to a location to be illuminated by the illumination source.

8. The apparatus according to claim 1, wherein the detector is to generate signals representative of the detected light, said apparatus further comprising:

a wireless interface to wirelessly communicate the signals to a destination receiver that is externally located with respect to a housing of the apparatus.

9. The apparatus according to claim 1, further comprising:

a housing that encapsulates the reservoir, the dispenser, the substrate, the illumination source, and the detector, wherein the housing is sized for handheld use.

11. A method for performing a sensing application on an analyte introduced onto a plurality of nano-fingers, said method comprising:

dispensing, from a reservoir, a solution onto a first subset of the plurality of nano-fingers, wherein Raman-active material nano-particles are attached to respective tips of the first subset of the plurality of nano-fingers;

dispensing, from a second reservoir, a second solution onto a second subset of the plurality of nano-fingers, wherein Raman-active material nano-particles are attached to respective tips of the second subset of the plurality of nano-fingers;

applying heat onto the first solution and the second solution to cause the first solution and the second solution to evaporate, wherein evaporation of the first solution and the second solution causes tips of adjacent ones of the plurality of nano-fingers to be drawn toward each other through capillary forces applied on the tips by the solution, and wherein molecules of the analyte are at least one of trapped between and positioned adjacent to the Raman-active material nano-particles attached to the respective tips that have been drawn toward each other;

illuminating the Raman-active material nano-particles and the analyte around the first subset of the plurality of nano fingers to cause enhanced Raman scattered light to be emitted from the analyte; and

detecting the enhanced Raman scattered light from analyte near the first subset of the plurality of nano fingers;

illuminating the Raman-active nano-particles and the analyte around the second subset of the plurality of nano-fingers to cause enhanced Raman scattered light to be emitted from the analyte near the second subset of the plurality of nano-fingers; and

detecting the enhanced Raman scattered light emitted from the analyte near the second subset of the plurality of nano-fingers.

12. The method according to claim 11, further comprising:

converting the detected Raman scattered light into electrical signals; and

wirelessly communicating the electrical signals.

13. The method according to claim 11, wherein illuminating the plurality of nano-fingers further comprises illuminating the plurality of nano-fingers with an illumination source, and wherein applying heat onto the solution further comprises applying heat from the illumination source.

14. The method of claim 11, wherein the plurality of nano-fingers are positioned in sufficiently close proximity to each other to cause the subset of the plurality of nano-fingers to collapse toward each other as the solution evaporates through application of capillary forces onto the plurality of nano-fingers in the subset by the solution.

15. An apparatus for performing a sensing application, said apparatus comprising:

a reservoir to contain a first solution;

a second reservoir to contain a second solution;

a substrate having a plurality of nano-fingers positioned to receive the dispensed solution, wherein the plurality of nano-fingers are flexible, such that the plurality of nano-fingers are configurable with respect to each other;

at least one dispenser to dispense the first solution from the first reservoir and the second solution from the second reservoir onto the plurality of nano-fingers so as to mix with the first solution and the second solution on the plurality of nano fingers to form a third mixed solution having an analyte;

an illumination source to illuminate the third solution on the plurality of nanofingers and the analyte introduced around the plurality of nano-fingers, wherein light is to be emitted from the analyte in response to being illuminated; and

a detector to detect the light emitted from the analyte.

16. The apparatus of claim 15 wherein the plurality of nano-fingers are positioned in sufficiently close proximity to each other to cause the subset of the plurality of nano-fingers to collapse toward each other as the third mixed solution evaporates through application of capillary forces onto the plurality of nano-fingers in the third mixed solution.