NASAL ADMINISTRATION
First Claim
Patent Images
1. A method of therapeutically treating a patient, comprising:
- administering, in a first step, a therapeutic agent to the patient; and
delivering, in a second step, to a location at an interior of a nasal passage of the patient a therapeutic amount of at least one of carbon dioxide or a pH adjusting material, wherein the first step is performed separately of the second step and or after before and the second step.
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Abstract
A method of delivering a substance, such as one or more of a triptan, a nasal steroid or carbon dioxide gas, to the nasal cavity of a subject, in particular for the treatment of headaches, for example, migraine, or rhinosinusitis, for example, chronic rhinosinusitis, optionally with polyps, the method comprising the steps of fitting a nosepiece to one nostril of the subject, delivering the substance through the nosepiece to the posterior region of the nasal cavity of the subject.
34 Citations
40 Claims
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1. A method of therapeutically treating a patient, comprising:
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administering, in a first step, a therapeutic agent to the patient; and delivering, in a second step, to a location at an interior of a nasal passage of the patient a therapeutic amount of at least one of carbon dioxide or a pH adjusting material, wherein the first step is performed separately of the second step and or after before and the second step. - View Dependent Claims (2, 3, 5, 6, 7, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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4. (canceled)
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8-11. -11. (canceled)
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22. A method for increasing a therapeutic effect of a pharmaceutical agent delivered to a patient, comprising:
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delivering, in a first step, a fluid flow to a nasal passage of the patient to deliver about 5% to about 6% vol/vol carbon dioxide to a posterior region of the nasal passage; and administering, in a second step, a dose of the pharmaceutical agent to the patient; wherein the second step is performed separately to the first step. - View Dependent Claims (23, 24)
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25-29. -29. (canceled)
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30. A method of treating a patient, comprising:
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delivering, in a first step, a concentration of about 5% to about 6% vol/vol carbon dioxide to an upper posterior region of a nasal passage of the patient to lower a pH of the upper posterior region of the nasal passage by at least about 0.1 pH units to provide a therapeutic or pharmacokinetic effect; and administering, in a second step, a therapeutic agent to the patient at least one of orally, intranasally, intravenously, and sub-cutaneously; wherein the second step is performed separately to the first step. - View Dependent Claims (32, 33, 39, 40)
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31. (canceled)
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34-38. -38. (canceled)
Specification