TRANSCUTANEOUS READER FOR USE WITH IMPLANTABLE ANALYTE SENSORS

• US 20160374556A1
• Filed: 06/27/2016
• Published: 12/29/2016
• Est. Priority Date: 06/25/2015
• Status: Abandoned Application

• Current Assignee: Profusa, Inc.
• Original Assignee: Profusa, Inc.
• Inventors: COLVIN, Arthur E. Jr., PULLINS, Steven, MCMILLAN, William A.
• Application Number:
  US15/193,711
• Publication Number:
  US 20160374556A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61B 2562/166 the sensor is mounted on a specially adapted printed circuit board
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/01 Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/14503 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors A61B5/1459, A61B5/1464, A61B5/1473, A61B5/1482, A61B5/14865 take precedence
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/686 Permanently implanted devices, e.g. pacemakers, other stimulators, biochips A61B5/6861 takes precedence
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal

Abstract

Some embodiments described herein relate to a reader having a distributed source of radiation and a photodetector. The photodetector can be operable to sense radiation (e.g., light) emitted by an implanted sensor. The distributed source of radiation can at least partially surrounds the photodetector. The distributed source of radiation generates a photon cloud of excitation radiation within the skin, which can substantially envelopes a sensor that is implanted within the skin at a depth that is on the order of a centimeter or less.

Claims

1. An apparatus, comprising:

a reader substrate;

a photodetector configured to receive light emitted by a sensor implanted at an implantation depth within tissue, the photodetector coupled to a central portion of the reader substrate;

a plurality of emitters, each emitter from the plurality of emitters coupled to a peripheral portion of the reader substrate, each emitter configured to produce a far-field illumination pattern at the implantation depth, each emitter spaced apart from each other emitter such that, in the absence of optical scattering induced by the tissue, the collective far-field illumination pattern of the plurality of emitters has a central dark region at the implantation depth.

2. The apparatus of claim 1, wherein each emitter is spaced apart from each other emitter such that, in the absence of optical scattering induced by the tissue, the far-filed illumination pattern of that emitter does not overlap a far-field illumination pattern of any other emitter at the implantation depth.

3. The apparatus of claim 1, wherein the far-field illumination pattern produced by each emitter from the plurality of emitters has a diameter at the implantation depth that is less than a length of the sensor in the absence of optical scattering induced by the tissue.

4. The apparatus of claim 1, wherein the reader substrate includes an isolation portion disposed on perimeter portion of the reader substrate peripheral to the plurality of emitters, the isolation portion configured to reflect light from the plurality of emitters towards the photodetector.

5. The apparatus of claim 1, wherein the reader substrate further includes an isolation portion disposed between the photodetector and the plurality of emitters, the isolation portion configured to reduce light emitted from the plurality of emitters, and scattered by tissue before reaching the sensor, from reaching the photodetector.

6. The apparatus of claim 1, wherein the plurality of emitters are collectively configured to illuminate an entire length of the sensor when the sensor is implanted into tissue.

7. The apparatus of claim 1, wherein the plurality of emitters are collectively configured such that the far-field illumination patterns of at least two of the plurality of emitters overlap at the implantation depth within the tissue.

8. The apparatus of claim 1, wherein the implantation depth is between 2 mm and 5 mm.

9. The apparatus of claim 1, wherein the implantation depth is between 1 mm and 10 mm.

10. An apparatus, comprising:

a reader substrate;

a photodetector configured to receive light emitted by a sensor implanted within tissue, the photodetector coupled to a central portion of the reader substrate;

a plurality of emitters, each emitter from the plurality of emitters coupled to the reader substrate at a position radial to the central portion of the reader substrate; and

a optical isolation member coupled to the reader substrate at a position radial to the plurality of emitters, the optical isolation member configured to reflect light emitted from each of the plurality of emitters towards the central portion of the reader substrate.

11. The apparatus of claim 10, wherein each emitter from the plurality of emitters is configured to produce a far-field illumination pattern at the implantation depth, each emitter spaced apart from each other emitter such that the far-field illumination pattern of that emitter does not overlap a far-field illumination pattern of any other emitter at the implantation depth in the absence of optical scattering induced by the tissue.

12. The apparatus of claim 10, wherein the plurality of emitters are collectively configured to emit light having a far-field emission pattern at the implantation depth, the far-field emission pattern, in the absence of scattering, having a central dark region.

13. The apparatus of claim 10, wherein the plurality of emitters are collectively configured to emit light having a far-field emission pattern at the implantation depth, the far-field emission pattern, in the absence of scattering, having a central dark region, the plurality of emitters collectively configured to emit light having a far-filed emission pattern not having the central dark region in the presence of scattering induced by the tissue.

14. The apparatus of claim 10, wherein:

the plurality of emitters are collectively configured to emit light having a far-field emission pattern at the implantation depth, the far-field emission pattern, in the absence of scattering, having a central dark region; and

the photodetector is configured to receive the light emitted by the sensor in response the sensor being illuminated by the far-field emission pattern, the light received by the photodetector having an intensity associated with an entire length of the sensor being illuminated.

15. The apparatus of claim 10, wherein the optical isolation member is a first optical isolation member, the apparatus further comprising:

a second optical isolation member coupled to the reader substrate between the plurality of emitters and the photodetector.

16. A method, comprising:

emitting a first cone of light from a first emitter such that the first cone of light illuminates a first portion of a sensor disposed within tissue at an implantation depth, the first cone of light emitted from the first emitter such that, in the absence of scattering or reflection, the first cone of light has a diameter at the implantation depth that is less than a length of the sensor;

emitting a second cone of light from a second emitter such that the second cone of light illuminates a second portion of the sensor, the second cone of light emitted from the second emitter such that, in the absence of scattering or reflection, the second cone of light has a diameter at the implantation depth that is less than the length of the sensor, the second emitter spaced apart from the first emitter such that the first cone of light and the second cone of light, in the absence of scattering or reflection, do not overlap at the implantation depth;

receiving, at a photodetector, an emission signal from the sensor, the emission signal produced by the sensor in response the sensor being illuminated by the first cone of light and the second cone of light, the emission signal having an intensity associated with an entire length of the sensor being illuminated by the first cone of light and the second cone of light, collectively.

17. The method of claim 16, wherein the first cone of light and the second cone of light collectively illuminate the entire length of the sensor in the presence of at least one of scattering or reflection.

18. The method of claim 16, wherein the first cone of light and the second cone of light overlap at the implantation depth in the presence of scattering induced by the tissue.

19. The method of claim 16, wherein the first emitter and the second emitter are from a plurality of emitters, the method further comprising:

emitting, from the plurality of emitters, a plurality of cones of light, each emitter from the plurality of emitters spaced apart from each other emitter such that each cone of light from the plurality of cones of light does not overlap any other cone of light at the implantation depth in the absence of scattering or reflection.

20. The method of claim 16, further comprising:

reflecting, towards the photodetector, a portion of the first cone of light from a perimeter of a substrate coupled to the first emitter, the second emitter, and the photodetector.

21. The method of claim 16, wherein:

the photodetector is coupled to a central portion of a reader substrate;

the first emitter and the second emitter are coupled to the reader substrate on opposite sides of the photodetector; and

the first emitter and the second emitter are spaced apart at a distance that prevents the first cone of light and the second cone of light from overlapping at the implantation depth, in the absence of scattering or reflection.

22. The method of claim 16, wherein the first emitter and the second emitter are from a plurality of emitters, the method further comprising:

emitting, from the plurality of emitters, a plurality of cones of light, the plurality of cones of light having a collective far-field illumination pattern at the implantation depth having a central dark region at the implantation depth in the absence of scattering.