NOVEL HETEROCYCLIC COMPOUNDS

• US 20160376277A1
• Filed: 02/02/2015
• Published: 12/29/2016
• Est. Priority Date: 02/03/2014
• Status: Active Grant

• Current Assignee: Cadila Healthcare Limited (Zydus Lifesciences Limited)
• Original Assignee: Cadila Healthcare Limited (Zydus Lifesciences Limited)
• Inventors: BAHEKAR, Rajesh, PATEL, Dipam, SHAH, Kiran, DESAI, Ranjit C.
• Granted Patent: US 9,840,509 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61K 31/4985 Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
• CPC Class Codes: A61K 31/519 ortho- or peri-condensed with heterocyclic rings
• CPC Class Codes: A61K 31/522 having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
• CPC Class Codes: A61K 31/5377 not condensed and containing further heterocyclic rings, e.g. timolol
• CPC Class Codes: A61K 31/55 having seven-membered rings, e.g. azelastine, pentylenetetrazole
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 11/02 Nasal agents, e.g. decongestants
• CPC Class Codes: A61P 11/06 Antiasthmatics
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 35/02 specific for leukemia
• CPC Class Codes: A61P 37/00 Drugs for immunological or allergic disorders
• CPC Class Codes: A61P 37/02 Immunomodulators
• CPC Class Codes: A61P 37/06 Immunosuppressants, e.g. drugs for graft rejection
• CPC Class Codes: A61P 37/08 Antiallergic agents antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C07D 473/34 attached in position 6, e.g. adenine
• CPC Class Codes: C07D 487/04 Ortho-condensed systems

Abstract

The present invention relates to heterocyclic compounds of the general formula (I) their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, enantiomers, diastereomers, and polymorphs. The invention also relates to processes for the preparation of the compounds of invention, pharmaceutical compositions containing the compounds and their use as selective Bruton'"'"'s Tyrosine Kinase (BTK) inhibitors.

Claims

1. Compound having the structure of general formula (I)

2. The compound as claimed in claim 1, wherein R₁ is selected from hydrogen, keto, halogen, unsubstituted or substituted groups selected from cyano, alkyl, haloalkyl groups.

3. The compound as claimed in claim 1, wherein R₂ is selected from the following ring system.

4. The compound as claimed in claim 1, wherein R₃ is selected from C(O)—

CH═

CH₂, C(O)—

CH═

CH—

R₄, SO₂—

NH(C_1-7)alkyl, SO₂—

CH═

CH₂, SO₂—

CH═

CH—

R₄ groups, wherein R₄ is as defined earlier.

5. The compound as claimed in claim 1, wherein U is selected from unsubstituted or substituted groups selected from aryloxyaryl, aryloxyalkyl, aryloxyheteroaryl, heteroaryloxyaryl, heteroaryloxyalkyl, heteroaryloxyheteroaryl, Ph-CO—

N(R₇R₈), Ph-N(R₉)—

CO—

R₁₀, wherein R₇ to R₁₀ are as defined earlier.

6. A compound as claimed in claim 1 selected from the group comprising of:

1-(5-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(benzo[d]thiazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(5-((4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)pyridin-2-yl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(2-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(2-methylbenzo[d]thiazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(benzo[b]thiophen-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(2,3-dihydrobenzo[b]thiophen-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(dibenzo[b,d]furan-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

N-(6-(1-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzo[d]thiazol-2-yl)acetamide;

1-(5-(4-amino-3-(2-methoxybenzo[d]thiazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-yn-1-one;

1-(5-(4-amino-3-(3-methoxy-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

4-(1-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(pyridin-2-yl)benzamide;

1-(5-(4-amino-3-(2-phenylbenzo[d]thiazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(benzo[d][1,3]dioxol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(benzo[d]oxazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

3-(4-phenoxyphenyl)-1-(2-(vinylsulfonyl)octahydrocyclopenta[c]pyrrol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;

1-(5-(4-amino-3-(2-phenylbenzo[d]oxazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(2-phenoxybenzo[d]thiazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(benzo[d]oxazol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(2-phenylbenzo[d]oxazol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

(E)-1-(5-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-4-(dimethylamino)but-2-en-1-one;

9-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-6-amino-7-(4-phenoxyphenyl)-5,7-dihydro-4H-purin-8(9H)-one;

1-(5-(4-amino-3-(4-(5-(pyridin-2-yl)-1,3,4-oxadiazol-2-yl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(4-amino-6-bromo-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

(E)-2-(5-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)octahydrocyclopenta[c]pyrrole-2-carbonyl)-3-cyclopropylacrylonitrile;

4-(1-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxy-N-(4-methylpyridin-2-yl)benzamide;

4-(1-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-methylpyridin-2-yl)benzamide;

1-(5-(4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

N-(4-(1-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)picolinamide;

6-amino-7-(4-phenoxyphenyl)-9-(2-(vinyl sulfonyl)octahydrocyclopenta[c]pyrrol-5-yl)-7H-purin-8(9H)-one;

4-(1-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(benzo[d]thiazol-2-yl)benzamide;

N-(4-(1-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)pyrazine-2-carboxamide;

1-(5-(4-amino-3-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

4-(1-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(pyrazin-2-yl)benzamide;

N-(4-(1-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)benzamide;

1-(5-(4-amino-3-(4-(5-(pyridin-2-yl)-1,3,4-thiadiazol-2-yl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

4-(1-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide;

Z)-methyl 4-(1-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-methylpyridin-2-yl)benzimidate;

6-(1-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-methylpyridin-2-yl)nicotinamide;

1-(5-(4-amino-3-(4-(pyridin-2-yloxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

(E)-4-(4-amino-1-(2-(4-(dimethylamino)but-2-enoyl)octahydrocyclopenta[c]pyrrol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(pyridin-2-yl)benzamide;

(E)-4-(4-amino-1-(2-(4-(dimethylamino)but-2-enoyl)octahydrocyclopenta[c]pyrrol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-methylpyridin-2-yl)benzamide;

1-(5-(4-amino-3-(4-(5-(pyrazin-2-yl)-1,3,4-thiadiazol-2-yl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

(E)-1-(5-(4-amino-3-(4-(pyridin-2-yloxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-4-(dimethylamino)but-2-en-1-one;

(E)-1-(5-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-4-(dimethylamino)but-2-en-1-one;

(E)-4-(4-amino-1-(2-(4-(dimethylamino)but-2-enoyl)octahydrocyclopenta[c]pyrrol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(pyrazin-2-yl)benzamide;

(Z)-methyl 4-(4-amino-1-(2-((E)-4-(dimethylamino)but-2-enoyl)octahydrocyclopenta[c]pyrrol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-methylpyridin-2-yl)benzimidate;

(E)-4-(4-amino-1-(2-(4-(dimethylamino)but-2-enoyl)octahydrocyclopenta[c]pyrrol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide;

1-(5-(4-amino-3-(4-(pyridin-3-yloxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

(E)-1-(5-(4-amino-3-(4-(pyridin-3-yloxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-4-(dimethylamino) but-2-en-1-one;

4-(1-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-methyl-N-(4-methylpyridin-2-yl)benzamide;

(E)-4-(4-amino-1-(2-(4-(dimethylamino)but-2-enoyl)octahydrocyclopenta[c]pyrrol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-methyl-N-(4-methyl pyridin-2-yl)benzamide;

(E)-1-(5-(4-amino-3-(4-(5-(pyrazin-2-yl)-1,3,4-thiadiazol-2-yl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-4-(dimethylamino)but-2-en-1-one;

(E)-1-(5-(4-amino-3-(4-(5-(pyridin-2-yl)-1,3,4-oxadiazol-2-yl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-4-(dimethylamino)but-2-en-1-one

7. A compound as claimed in claim 1 selected from the group comprising of:

1-(5-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(benzo[d]thiazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(5-((4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)pyridin-2-yl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(2-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(2-methylbenzo[d]thiazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(benzo[b]thiophen-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(2,3-dihydrobenzo[b]thiophen-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(dibenzo[b,d]furan-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

N-(6-(1-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzo[d]thiazol-2-yl)acetamide;

1-(5-(4-amino-3-(2-methoxybenzo[d]thiazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-yn-1-one;

1-(5-(4-amino-3-(3-methoxy-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

4-(1-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(pyridin-2-yl)benzamide;

1-(5-(4-amino-3-(2-phenylbenzo[d]thiazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(benzo[d][1,3]dioxol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(benzo[d]oxazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

3-(4-phenoxyphenyl)-1-(2-(vinyl sulfonyl)octahydrocyclopenta[c]pyrrol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;

1-(5-(4-amino-3-(2-phenylbenzo[d]oxazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(2-phenoxybenzo[d]thiazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(benzo[d]oxazol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(2-phenylbenzo[d]oxazol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

(E)-1-(5-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl) hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-4-(dimethylamino)but-2-en-1-one;

9-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-6-amino-7-(4-phenoxyphenyl)-5, 7-dihydro-4H-purin-8(9H)-one;

1-(5-(4-amino-3-(4-(5-(pyridin-2-yl)-1,3,4-oxadiazol-2-yl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(4-amino-6-bromo-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

(E)-2-(5-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)octahydrocyclopenta[c]pyrrole-2-carbonyl)-3-cyclopropylacrylonitrile;

4-(1-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxy-N-(4-methylpyridin-2-yl)benzamide;

4-(1-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-methylpyridin-2-yl)benzamide;

1-(5-(4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl) hexa hydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

N-(4-(1-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)picolinamide;

6-amino-7-(4-phenoxyphenyl)-9-(2-(vinyl sulfonyl)octahydrocyclopenta[c]pyrrol-5-yl)-7H-purin-8 (9H)-one;

4-(1-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(benzo[d]thiazol-2-yl)benzamide;

N-(4-(1-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)pyrazine-2-carb oxamide;

1-(5-(4-amino-3-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

4-(1-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(pyrazin-2-yl)benzamide;

N-(4-(1-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)benzamide;

1-(5-(4-amino-3-(4-(5-(pyridin-2-yl)-1,3,4-thiadiazol-2-yl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

4-(1-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide;

Z)-methyl 4-(1-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-methylpyridin-2-yl)benzimidate;

6-(1-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-methylpyridin-2-yl)nicotinamide;

1-(5-(4-amino-3-(4-(pyridin-2-yloxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

(E)-4-(4-amino-1-(2-(4-(dimethylamino)but-2-enoyl)octahydrocyclopenta[c]pyrrol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(pyridin-2-yl)benzamide;

(E)-4-(4-amino-1-(2-(4-(dimethylamino)but-2-enoyl)octahydrocyclopenta[c]pyrrol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-methylpyridin-2-yl)benzamide;

1-(5-(4-amino-3-(4-(5-(pyrazin-2-yl)-1,3,4-thiadiazol-2-yl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

(E)-1-(5-(4-amino-3-(4-(pyridin-2-yloxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-4-(dimethylamino) but-2-en-1-one;

(E)-1-(5-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-4-(dimethylamino)but-2-en-1-one;

(E)-4-(4-amino-1-(2-(4-(dimethylamino)but-2-enoyl)octahydrocyclopenta[c]pyrrol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(pyrazin-2-yl)benzamide;

(Z)-methyl 4-(4-amino-1-(2-((E)-4-(dimethylamino)but-2-enoyl)octahydrocyclopenta[c]pyrrol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-methylpyridin-2-yl)benzimidate;

(E)-4-(4-amino-1-(2-(4-(dimethylamino)but-2-enoyl)octahydrocyclopenta[c]pyrrol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-(trifluoromethyl)pyridine-2-yl)benzamide;

1-(5-(4-amino-3-(4-(pyridin-3-yloxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

(E)-1-(5-(4-amino-3-(4-(pyridin-3-yloxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-4-(dimethyl amino) but-2-en-1-one;

4-(1-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-methyl-N-(4-methylpyridin-2-yl)benzamide;

(E)-4-(4-amino-1-(2-(4-(dimethylamino)but-2-enoyl)octahydrocyclopenta[c]pyrrol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-methyl-N-(4-methylpyridin-2-yl)benzamide;

(E)-1-(5-(4-amino-3-(4-(5-(pyrazin-2-yl)-1,3,4-thiadiazol-2-yl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-4-(dimethylamino)but-2-en-1-one;

(E)-1-(5-(4-amino-3-(4-(5-(pyridin-2-yl)-1,3,4-oxadiazol-2-yl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-4-(dimethylamino)but-2-en-1-one;

1-(5-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-5,6-dihydrocyclopenta[c]pyrrol-2(1H,3H,4H)-yl)prop-2-en-1-one;

2-acryloyl-5-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-2,3-dihydrocyclopenta[c]pyrrole-4,6(1H,5H)-dione;

2-acryloyl-5-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-5,6-dihydrocyclopenta[c]pyrrole-1,3(2H,4H)-dione;

1-(5-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl) hexahydrocyclopenta[b]pyrrol-1(2H)-yl)prop-2-en-1-one;

1-(4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-2,3,5,6-tetrahydrocyclopenta[b]pyrrol-1(4H)-yl)prop-2-en-1-one;

1-(6-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydro-1H-cyclopenta[c]pyridin-2(3H)-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)prop-2-en-1-one;

1-(6-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3-azabicyclo[3.2.0]heptan-3-yl)prop-2-en-1-one;

1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-6-azabicyclo[3.2.0]heptan-6-yl)prop-2-en-1-one;

N-(5-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)octahydropentalen-2-yl)acrylamide;

1-(5-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4,6,7-tetrahydro-1H-cyclopenta[c]pyridin-2(5H)-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydro-1H-isoindol-2(3H)-yl)prop-2-en-1-one;

1-(4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[b]pyrrol-1(2H)-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-2,3,5, 6-tetrahydrocyclopenta[b]pyrrol-1(4H)-yl)prop-2-en-1-one;

1-(4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-5,6-dihydrocyclopenta[c]pyrrol-2(1H,3H,4H)-yl)prop-2-en-1-one;

1-(6-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)octahydro-1H-cyclopenta[b]pyridin-1-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-2,3,4,5,6,7-hexahydro-1H-cyclopenta[b]pyridin-1-yl)prop-2-en-1-one;

1-(7-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-2,3,4,5,6,7-hexahydro-1H-cyclopenta[b]pyridin-1-yl)prop-2-en-1-one;

1-(6-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4,6,7-tetrahydro-1H-cyclopenta[c]pyridin-2(5H)-yl)prop-2-en-1-one;

1-(7-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4,6,7-tetrahydro-1H-cyclopenta[c]pyridin-2(5H)-yl)prop-2-en-1-one;

1-(7-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-2,3,4,5,6,7-hexahydro-1H-cyclopenta[b]pyridin-1-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(benzo[d]thiazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-5, 6-dihydrocyclopenta[c]pyrrol-2(1H,3H,4H)-yl)prop-2-en-1-one;

2-acryloyl-5-(4-amino-3-(benzo[d]thiazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-2,3-dihydrocyclopenta[c]pyrrole-4,6(1H,5H)-dione;

2-acryloyl-5-(4-amino-3-(benzo[d]thiazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-5,6-dihydrocyclopenta[c]pyrrole-1,3(2H,4H)-dione;

1-(5-(4-amino-3-(benzo[d]thiazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[b]pyrrol-1(2H)-yl)prop-2-en-1-one;

1-(4-(4-amino-3-(benzo[d]thiazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-2,3,5,6-tetrahydrocyclopenta[b]pyrrol-1(4H)-yl)prop-2-en-1-one;

1-(6-(4-amino-3-(benzo[d]thiazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydro-1H-cyclopenta[c]pyridin-2(3H)-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(benzo[d]thiazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)prop-2-en-1-one;

1-(6-(4-amino-3-(benzo[d]thiazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3-azabicyclo[3.2.0]heptan-3-yl)prop-2-en-1-one;

1-(3-(4-amino-3-(benzo[d]thiazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-6-azabicyclo[3.2.0]heptan-6-yl)prop-2-en-1-one;

N-(5-(4-amino-3-(benzo[d]thiazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)octahydropentalen-2-yl)acrylamide;

1-(5-(4-amino-3-(benzo[d]thiazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4,6,7-tetrahydro-1H-cyclopenta[c]pyridin-2(5H)-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(benzo[d]thiazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydro-1H-isoindol-2(3H)-yl)prop-2-en-1-one;

1-(4-(4-amino-3-(benzo[d]thiazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(4-(4-amino-3-(benzo[d]thiazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[b]pyrrol-1(2H)-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(benzo[d]thiazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-2,3,5,6-tetrahydrocyclopenta[b]pyrrol-1(4H)-yl)prop-2-en-1-one;

1-(4-(4-amino-3-(benzo[d]thiazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-5,6-dihydrocyclopenta[c]pyrrol-2(1H,3H,4H)-yl)prop-2-en-1-one;

1-(6-(4-amino-3-(benzo[d]thiazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)octahydro-1H-cyclopenta[b]pyridin-1-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(benzo[d]thiazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-2,3,4,5,6,7-hexahydro-1H-cyclopenta[b]pyridin-1-yl)prop-2-en-1-one;

1-(7-(4-amino-3-(benzo[d]thiazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-2,3,4,5,6,7-hexahydro-1H-cyclopenta[b]pyridin-1-yl)prop-2-en-1-one;

1-(6-(4-amino-3-(benzo[d]thiazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4,6,7-tetrahydro-1H-cyclopenta[c]pyridin-2(5H)-yl)prop-2-en-1-one;

1-(7-(4-amino-3-(benzo[d]thiazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4,6,7-tetrahydro-1H-cyclopenta[c]pyridin-2(5H)-yl)prop-2-en-1-one;

1-(7-(4-amino-3-(benzo[d]thiazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-2,3,4,5,6,7-hexahydro-1H-cyclopenta[b]pyridin-1-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(benzo[b]thiophen-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-5,6-dihydrocyclopenta[c]pyrrol-2(1H,3H,4H)-yl)prop-2-en-1-one;

1-(6-(4-amino-3-(benzo[b]thiophen-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydro-1H-cyclopenta[c]pyridin-2(3H)-yl)prop-2-en-1-one;

1-(6-(4-amino-3-(benzo[b]thiophen-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3-azabicyclo[3.2.0]heptan-3-yl)prop-2-en-1-one;

N-(5-(4-amino-3-(benzo[b]thiophen-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)octahydropentalen-2-yl)acrylamide;

1-(5-(4-amino-3-(benzo[b]thiophen-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4,6,7-tetrahydro-1H-cyclopenta[c]pyridin-2(5H)-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(2,3-dihydrobenzo[b]thiophen-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-5,6-dihydrocyclopenta[c]pyrrol-2(1H,3H,4H)-yl)prop-2-en-1-one;

1-(6-(4-amino-3-(2,3-dihydrobenzo[b]thiophen-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydro-1H-cyclopenta[c]pyridin-2(3H)-yl)prop-2-en-1-one

1-(6-(4-amino-3-(2,3-dihydrobenzo[b]thiophen-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3-azabicyclo[3.2.0]heptan-3-yl)prop-2-en-1-one;

N-(5-(4-amino-3-(2,3-dihydrobenzo[b]thiophen-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)octahydropentalen-2-yl)acrylamide;

1-(5-(4-amino-3-(2,3-dihydrobenzo[b]thiophen-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4,6,7-tetrahydro-1H-cyclopenta[c]pyridin-2(5H)-yl)prop-2-en-1-one;

N-(6-(1-(2-acryloyl-1,2,3,4,5,6-hexahydrocyclopenta[c]pyrrol-5-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzo[d]thiazol-2-yl)acetamide;

N-(6-(1-(2-acryloyloctahydro-1H-cyclopenta[c]pyridin-6-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzo[d]thiazol-2-yl)acetamide;

N-(5-(3-(2-acetamidobenzo[d]thiazol-6-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)octahydropentalen-2-yl)acrylamide;

(E)-1-(5-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-5, 6-dihydrocyclopenta[c]pyrrol-2(1H,3H,4H)-yl)-4-(dimethylamino)but-2-en-1-one;

(E)-1-(6-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydro-1H-cyclopenta[c]pyridin-2(3H)-yl)-4-(dimethylamino)but-2-en-1-one;

(E)-1-(6-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3-azabicyclo[3.2.0]heptan-3-yl)-4-(dimethylamino)but-2-en-1-one;

(E)-1-(5-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4,6, 7-tetrahydro-1H-cyclopenta[c]pyridin-2(5H)-yl)-4-(dimethylamino)but-2-en-1-one;

(E)-1-(5-(4-amino-3-(benzo[d]thiazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-4-(dimethylamino)but-2-en-1-one;

(E)-1-(5-(4-amino-3-(benzo[d]thiazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-5,6-dihydrocyclopenta[c]pyrrol-2(1H,3H,4H)-yl)-4-(dimethylamino)but-2-en-1-one;

(E)-1-(6-(4-amino-3-(benzo[d]thiazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydro-1H-cyclopenta[c]pyridin-2(3H)-yl)-4-(dimethylamino)but-2-en-1-one;

(E)-1-(6-(4-amino-3-(benzo[d]thiazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3-azabicyclo[3.2.0]heptan-3-yl)-4-(dimethylamino)but-2-en-1-one;

(E)-1-(5-(4-amino-3-(benzo[d]thiazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4, 6,7-tetrahydro-1H-cyclopenta[c]pyridin-2(5H)-yl)-4-(dimethylamino)but-2-en-1-one;

1-(5-(4-amino-3-(4-benzoylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

4-(1-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-phenylbenzamide;

4-(1-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-methyl-N-phenylbenzamide;

4-(1-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methyl-N-phenylbenzamide

4-(1-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxy-N-phenylbenzamide;

4-(1-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N,2-dimethyl-N-phenylbenzamide;

4-(1-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxy-N-methyl-N-phenylbenzamide;

4-(1-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methyl-N-(pyridin-2-yl)benzamide;

4-(1-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxy-N-(pyridin-2-yl)benzamide;

4-(1-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methyl-N-(4-methylpyridin-2-yl)benzamide;

4-(1-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methyl-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide;

4-(1-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxy-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide;

4-(7-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-6-chloro-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-phenylbenzamide;

4-(7-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-6-fluoro-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-phenylbenzamide;

4-(7-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-6-bromo-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-phenylbenzamide;

4-(7-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-6-(difluoro methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-phenylbenzamide;

4-(7-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-6-(trifluoro methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-phenylbenzamide;

4-(7-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-6-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-phenylbenzamide;

4-(7-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-phenylbenzamide;

4-(7-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-methyl-N-phenylbenzamide;

4-(7-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(pyridin-2-yl)benzamide;

4-(7-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-methyl-N-(pyridin-2-yl)benzamide;

4-(7-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(4-methylpyridin-2-yl)benzamide;

4-(7-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-methyl-N-(4-methylpyridin-2-yl)benzamide;

4-(7-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-methyl-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide;

4-(7-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide;

4-(7-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-methyl-N-phenylbenzamide;

4-(7-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-methoxy-N-phenylbenzamide;

4-(7-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N,2-dimethyl-N-phenylbenzamide;

4-(7-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-methoxy-N-methyl-N-phenylbenzamide;

4-(7-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-methyl-N-(pyridin-2-yl)benzamide;

4-(7-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-methoxy-N-(pyridin-2-yl)benzamide;

4-(7-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N,2-dimethyl-N-(pyridin-2-yl)benzamide;

4-(7-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-methoxy-N-methyl-N-(pyridin-2-yl)benzamide;

4-(7-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-methyl-N-(4-methylpyridin-2-yl)benzamide;

4-(7-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-methoxy-N-(4-methylpyridin-2-yl)benzamide;

4-(7-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N,2-dimethyl-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide;

4-(7-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-methoxy-N-methyl-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide;

4-(7-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-methyl-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide;

4-(7-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-methoxy-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide;

4-(3-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-8-aminoimidazo[1,5-a]pyrazin-1-yl)-N-phenylbenzamide;

4-(3-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-8-aminoimidazo[1,5-a]pyrazin-1-yl)-N-methyl-N-phenylbenzamide;

4-(3-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-8-aminoimidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide;

4-(3-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-8-aminoimidazo[1,5-a]pyrazin-1-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide;

4-(3-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-8-aminoimidazo[1,5-a]pyrazin-1-yl)-2-methoxy-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide;

4-(9-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-6-amino-8-oxo-8,9-dihydro-7H-purin-7-yl)-N-phenylbenzamide;

4-(9-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-6-amino-8-oxo-8,9-dihydro-7H-purin-7-yl)-N-methyl-N-phenylbenzamide;

4-(9-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-6-amino-8-oxo-8,9-dihydro-7H-purin-7-yl)-N-(pyridin-2-yl)benzamide;

4-(9-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-6-amino-8-oxo-8,9-dihydro-7H-purin-7-yl)-N-(4-methylpyridin-2-yl)benzamide;

4-(9-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-6-amino-8-oxo-8,9-dihydro-7H-purin-7-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide;

4-(9-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-6-amino-8-oxo-8,9-dihydro-7H-purin-7-yl)-2-methoxy-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide;

4-(1-(2-acryloyl-1,2,3,4,5,6-hexahydrocyclopenta[c]pyrrol-5-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-phenylbenzamide;

4-(1-(1-acryloyloctahydrocyclopenta[b]pyrrol-5-yl)-4-amino-1H-pyrazolo[3, 4-d]pyrimidin-3-yl)-N-phenylbenzamide;

4-(4-amino-1-(2-(vinylsulfonyl)octahydrocyclopenta[c]pyrrol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-phenylbenzamide;

(E)-4-(4-amino-1-(2-(4-(dimethylamino)but-2-enoyl)octahydrocyclopenta[c]pyrrol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-phenylbenzamide;

(E)-4-(4-amino-1-(2-(4-(cyclopropyl(methyl)amino)but-2-enoyl)octahydrocyclopenta[c]pyrrol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-phenyl benzamide;

(Z)-4-(4-amino-1-(2-(2-cyano-3-cyclopropylacryloyl)octahydrocyclopenta[c]pyrrol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-phenylbenzamide;

4-(7-(2-acryloyl-1,2,3,4,5,6-hexahydrocyclopenta[c]pyrrol-5-yl)-4-amino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-phenylbenzamide;

4-(7-(1-acryloyloctahydrocyclopenta[b]pyrrol-5-yl)-4-amino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-phenylbenzamide;

4-(4-amino-7-(2-(vinylsulfonyl)octahydrocyclopenta[c]pyrrol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-phenylbenzamide;

(E)-4-(4-amino-7-(2-(4-(dimethylamino)but-2-enoyl)octahydrocyclopenta[c]pyrrol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-phenylbenzamide;

(E)-4-(4-amino-7-(2-(4-(cyclopropyl(methyl)amino)but-2-enoyl)octahydro cyclopenta[c]pyrrol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-phenyl benzamide;

(Z)-4-(4-amino-7-(2-(2-cyano-3-cyclopropylacryloyl)octahydrocyclopenta[c]pyrrol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-phenylbenzamide;

4-(3-(2-acryloyl-1,2,3,4,5,6-hexahydrocyclopenta[c]pyrrol-5-yl)-8-amino imidazo[1,5-a]pyrazin-1-yl)-N-phenylbenzamide;

4-(3-(1-acryloyloctahydrocyclopenta[b]pyrrol-5-yl)-8-aminoimidazo[1,5-a]pyrazin-1-yl)-N-phenylbenzamide;

4-(8-amino-3-(2-(vinylsulfonyl)octahydrocyclopenta[c]pyrrol-5-yl)imidazo[1,5-a]pyrazin-1-yl)-N-phenylbenzamide;

(E)-4-(8-amino-3-(2-(4-(dimethylamino)but-2-enoyl)octahydrocyclopenta[c]pyrrol-5-yl)imidazo[1,5-a]pyrazin-1-yl)-N-phenylbenzamide;

(E)-4-(8-amino-3-(2-(4-(cyclopropyl(methyl)amino)but-2-enoyl)octahydroyclopenta[c]pyrrol-5-yl)imidazo[1,5-a]pyrazin-1-yl)-N-phenylbenzamide;

(Z)-4-(8-amino-3-(2-(2-cyano-3-cyclopropylacryloyl)octahydrocyclopenta[c]pyrrol-5-yl)imidazo[1,5-a]pyrazin-1-yl)-N-phenylbenzamide;

4-(9-(2-acryloyl-1,2,3,4,5,6-hexahydrocyclopenta[c]pyrrol-5-yl)-6-amino-8-oxo-8, 9-dihydro-7H-purin-7-yl)-N-phenylbenzamide;

4-(9-(1-acryloyloctahydrocyclopenta[b]pyrrol-5-yl)-6-amino-8-oxo-8, 9-dihydro-7H-purin-7-yl)-N-phenylbenzamide;

4-(6-amino-8-oxo-9-(2-(vinyl sulfonyl)octahydrocyclopenta[c]pyrrol-5-yl)-8, 9-dihydro-7H-purin-7-yl)-N-phenylbenzamide;

(E)-4-(6-amino-9-(2-(4-(dimethylamino)but-2-enoyl)octahydrocyclopenta[c]pyrrol-5-yl)-8-oxo-8, 9-dihydro-7H-purin-7-yl)-N-phenylbenzamide;

(E)-4-(6-amino-9-(2-(4-(cyclopropyl(methyl)amino)but-2-enoyl)octahydro cyclopenta[c]pyrrol-5-yl)-8-oxo-8, 9-dihydro-7H-purin-7-yl)-N-phenyl benzamide;

(Z)-4-(6-amino-9-(2-(2-cyano-3-cyclopropylacryloyl)octahydrocyclopenta[c]pyrrol-5-yl)-8-oxo-8, 9-dihydro-7H-purin-7-yl)-N-phenylbenzamide;

1-(5-(4-amino-3-(4-(5-phenyl-1,3,4-oxadiazol-2-yl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(4-amino-6-chloro-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(4-amino-6-(difluoromethyl)-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(8-amino-1-(4-phenoxyphenyl)imidazo[1,5-a]pyrazin-3-yl)hexahydro cyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(4-phenoxyphenyl)-3-(2-(vinyl sulfonyl)octahydrocyclopenta[c]pyrrol-5-yl)imidazo[1,5-a]pyrazin-8-amine;

7-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-5-(4-phenoxy phenyl)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid;

4-(1-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(5-chloropyridin-2-yl)benzamide;

1-(5-(4-amino-3-(4-(morpholinomethyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(4-(piperidin-1-ylmethyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(4-((3,4-dihydroisoquinolin-2(1H)-yl)methyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(4-((tetrahydrofuran-2-yl)oxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(4-(1-morpholinoethyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(4-(pyrrolidin-1-ylmethyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(4-((dimethylamino)methyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

N-(4-(1-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzyl)acetamide;

1-(5-(4-amino-3-(4-(2-morpholinoethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

2-(4-(1-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzyl)isoindoline-1,3-dione;

1-(5-(4-amino-3-(4-((3,4-dihydroisoquinolin-2(1H)-yl)methyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(4-(azepan-1-yl)methyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(4-((hexahydro-1H-isoindol-2(3H)-yl)methyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(4-(thiomorpholinomethyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

1-(5-(4-amino-3-(4-((1,1-dioxidobenzo[d]isothiazol-2(3H)-yl)methyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)prop-2-en-1-one;

2-(4-(1-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzyl)isoindolin-1-one;

9-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-6-amino-7-(benzo[d]thiazol-6-yl)-7H-purin-8(9H)-one;

4-(9-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-6-amino-8-oxo-8,9-dihydro-7H-purin-7-yl)-N-methyl-N-(4-methylpyridin-2-yl)benzamide;

9-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-6-amino-7-(4-((methyl(4-methylpyridin-2-yl)amino)methyl)phenyl)-7H-purin-8(9H)-one;

4-(9-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-6-amino-8-oxo-8,9-dihydro-7H-purin-7-yl)-N-(pyridin-2-yl)benzamide;

9-(2-acryloyloctahydrocyclopenta[c]pyrrol-5-yl)-6-amino-7-(4-benzoylphenyl)-7H-purin-8(9H)-one

8. A pharmaceutical composition comprising a therapeutically effective amount of a compound of Formula (I) as claimed in any of the preceding claims and optionally one or more pharmaceutically acceptable carriers, diluents or excipients.

10. A method of treating a disease, disorder or condition, which would benefit from inhibition of tyrosine kinase (s), such as BTK activity comprising administering to a patient in need thereof an effective amount of a compound of Formula (I) according to any of the preceding claims or its suitable pharmaceutical composition.

11. A medicine for the treatment of a disease, disorder or condition, which would benefit from inhibition of tyrosine kinase (s), such as BTK activity, which comprises administering a therapeutically effective amount of compound of Formula (I) or its pharmaceutical composition as defined in any of the preceding claims to a patient or subject in need thereof.

12. A pharmaceutical composition comprising the compound of the present invention in combination with one or more suitable pharmaceutically active agents selected from following therapeutic agents in any combination. Immunosuppressants (eg., Methotrexate, mercaptopurine, cyclophosphamide), glucocorticoids, non-steroidal anti-inflammatory drugs, Cox-2 specific inhibitors, TNF- binding proteins (eg., Infliximab, etanercept), interferon-13, interferon-, interleukin-2, antihistamines, beta-agonist, anticolinergics, anti-cancer agents or their suitable pharmaceutically acceptable salts. Further examples of anticancer agents for use in combination with BTK inhibitors include chemotherapy or a targeted therapy, alkylating agents, platinum compounds, DNA altering agents, Topoisomerase inhibitors, microtubule modifiers, antimetabolites, anticancer antibiotics, hormones, Aromatase inhibitors, antibodies, cytokines, vaccines, drug conjugates, inhibitors of mitogen-activated protein kinase signaling (ex:

BAY 43-9006), Syk inhibitors, mTOR inhibitors, antibodies (Rituxan), other anticancer agents that can be employed in combination include, Vinblastin, Bleomycin, Cisplatin, Acivicin, Azacitidine, Decitabine, Doxorubicin, Enloplatin, Flurouracil, Methotrexate, Vinblastin, Vincristine and BCR/ABL antagonist. Use of a compound of Formula (I) or its pharmaceutical composition according to any of the preceding claims for the manufacture of a medicament for treating a disease, disorder or condition, which would benefit from inhibition of tyrosine kinase (s), such as BTK activity.

9. The pharmaceutical composition which is useful for treating a disease, disorder or condition, which would benefit from inhibition of tyrosine kinase (s), such as BTK activity to provide clinical benefit in diseases such as autoimmune disorders, an inflammatory disease, or an allergy disease selected from rheumatoid arthritis or lupus erythromatosis, asthma, allergic rhintis, B-cell proliferative disorder such as B-cell lymphoma, multiple sclerosis, mantle cell lymphoma, chronic lymphocytic lymphoma/leukemia, diffuse large B-cell lymphoma, Follicular lymphoma or chronic lymphocytic leukemia, B-cell prolymphocytic leukemia.

13. Use of the compound of formula (I) and a suitable pharmaceutically acceptable agent selected from anti-cancer and anti-inflammatory agents or their pharmaceutically acceptable salts for the treatment of autoimmune and allergic disorders, such as rheumatoid arthritis, systemic lupus erythromatosis, scleroderma, asthma, allergic rhinitis, allergic eczema, B-cell lymphoma, multiple sclerosis, juvenile rheumatoid arthritis, juvenile idiopathic arthritis, inflammatory bowel disease, graft versus host disease, psoriatic arthritis, ankylosing spondylitis and uveritis, B cell lymphoma, multiple sclerosis, diffuse large B-cell lymphoma, follicular lymphoma or chronic lymphocytic leukemia and B-cell prolymphocytic leukemia.