SYSTEM AND METHOD OF MONITORING AUTOREGULATION

• US 20170000395A1
• Filed: 06/27/2016
• Published: 01/05/2017
• Est. Priority Date: 06/30/2015
• Status: Active Grant

• Current Assignee: Covidien LP (Medtronic Plc)
• Original Assignee: Covidien LP (Medtronic Plc)
• Inventors: Addison, Paul S., Watson, James N.
• Granted Patent: US 10,271,779 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/02108 from analysis of pulse wave characteristics
• CPC Class Codes: A61B 5/14553 specially adapted for cerebral tissue
• CPC Class Codes: A61B 5/7221 Determining signal validity, reliability or quality A61B5/7207 and A61B5/7217 take precedence
• CPC Class Codes: G16H 50/20 for computer-aided diagnosis, e.g. based on medical expert systems
• CPC Class Codes: G16H 50/50 for simulation or modelling of medical disorders

Abstract

A method for monitoring autoregulation includes using a processor for receiving blood pressure data and oxygen saturation data from a patient, fitting a dynamic model to the blood pressure data and the oxygen saturation data to determine one or more parameters of the dynamic model indicative of autoregulation, and determining the patient'"'"'s autoregulation status based on the one or more parameters.

Claims

1. A method for monitoring autoregulation comprising:

using a processor for;

receiving blood pressure data and oxygen saturation data from a patient;

fitting a dynamic model to the blood pressure data and the oxygen saturation data to determine one or more parameters of the dynamic model indicative of autoregulation; and

determining the patient'"'"'s autoregulation status based on the one or more parameters.

2. The method of claim 1, wherein determining the patient'"'"'s autoregulation status comprises comparing the one or more parameters to predetermined values, ranges, or thresholds.

3. The method of claim 1, comprising using the processor for determining a degree of impairment of the patient'"'"'s autoregulation system.

4. The method of claim 1, wherein the dynamic model comprises a differential equation model.

5. The method of claim 1, wherein the dynamic model comprises a damped dynamic oscillator model.

6. The method of claim 1, wherein the dynamic model has the following form:

A{umlaut over (x)}^a+B{dot over (x)}^bCx^c+D=P*,

where x is an oxygen saturation value, P* is a pressure forcing function, D is a constant, and A, a, B, b, C, and c are parameters.

7. The method of claim 1, wherein the dynamic model comprises a finite element model, a finite difference model, a wave tracing model, or a delay differential equation.

8. The method of claim 1, comprising using the processor for constructing the dynamic model based on empirical data.

9. The method of claim 1, comprising using the processor to fit the dynamic model to the blood pressure data and the oxygen saturation data only when the blood pressure data indicates a step change in the patient'"'"'s blood pressure.

10. The method of claim 1, comprising providing an indication of the patient'"'"'s autoregulation status on a display.

11. A non-transitory computer-readable medium having computer executable code stored thereon, the code comprising instructions to:

receive blood pressure data and oxygen saturation data from a patient;

fit a dynamic model to the blood pressure data and the oxygen saturation data to identify one or more parameters of the dynamic model indicative of autoregulation; and

determine the patient'"'"'s autoregulation status based on the one or more parameters.

12. The non-transitory computer-readable medium of claim 11, wherein the code comprises instructions to compare the one or more parameters to predetermined values, ranges, or thresholds to facilitate determination of the patient'"'"'s autoregulation status.

13. The non-transitory computer-readable medium of claim 11, wherein the dynamic model comprises a damped dynamic oscillator model.

14. The non-transitory computer-readable medium of claim 11, wherein the code comprises instructions to determine a degree of impairment of the patient'"'"'s autoregulation system.

15. The non-transitory computer-readable medium of claim 11, wherein the code comprises instructions to provide an indication of the patient'"'"'s autoregulation status on a display.

16. A system for monitoring autoregulation comprising:

an oxygen saturation sensor configured to obtain an oxygen saturation data from a patient;

a controller comprising a processor configured to;

receive blood pressure data and the oxygen saturation data;

fit a dynamic model to the blood pressure data and the oxygen saturation data to identify one or more parameters of the dynamic model indicative of autoregulation; and

determine the patient'"'"'s autoregulation status based on the one or more parameters.

17. The system of claim 16, wherein the processor is configured to compare the one or more parameters to predetermined values, ranges, or thresholds to determine the patient'"'"'s autoregulation status.

18. The system of claim 16, wherein the processor is configured to determine a degree of impairment of the patient'"'"'s autoregulation system.

19. The system of claim 16, wherein the dynamic model comprises a damped dynamic oscillator model.

20. The system of claim 16, comprising a display, and wherein the processor is configured to output an indication of the patient'"'"'s autoregulation status to the display.