DEVICE AND METHOD OF PERSONALIZED MEDICINE
First Claim
1. A method for the treatment of a first patient comprising the steps of:
- accepting a first xenograft from a first location in the first patient comprising cells of a first neoplasm;
placing in a vivarium a first set of animals in one or more cages;
subdividing the first set of animals into one or more subsets;
identifying a negative phenotype;
wherein the negative phenotype comprises behaviors and physiological indicators that are consistent with the first set of animals receiving no placement of cells of the first xenograft and no therapeutic treatment;
placing at least a portion of the first xenograft in a first location in the brain of each animal (a “
subject animal”
) in the one or more subsets of animals;
wherein the first location in the brain is associated with a first known set of animal behaviors;
identifying a positive phenotype, wherein the positive phenotype comprises behaviors and physiological indicators that are compatible unhealthy functioning of the first location of the first organ of the first set of animals;
treating each of the one or more subsets with an associated treatment regimen, wherein the associated treatment regimen for each subset is unique;
aggregating, measuring and timing one or more phenotype of the one or more subsets of animals, the “
treatment phenotypes”
;
comparing the treatment phenotypes of each one or more subsets to both the negative baseline phenotype and the positive baseline phenotype;
selecting a regimen responsive to some combination of;
(a) (the least difference between the treatment phenotype and the negative baseline phenotype) and (b) (the largest difference between the treatment phenotype and the set of positive baseline phenotype), for each associated treatment phenotype associated with the regimen; and
treating the first patient with the selected regimen.
1 Assignment
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Accused Products
Abstract
The field of this invention is personalized medicine. A tissue sample is taken from a patient, optionally amplified, and injected into animals, such as mice in a vivarium. Animals receive one or more therapeutic treatments. Animal behaviors are collected, measured and timed using fully automatic, continuous monitoring using per-cage sensors, where behavior recording is free of human, manual actions. Observed behavior is consistent with healthy or unhealthy behaviors specific to the injection site, typically in a specific organ or location in an organ, such as the brain. The injection site may be consistent with the source site from the patient. Both positive and negative baseline behaviors are collected, typically using the same device or method. Treatment selection is responsive to differences between treated and untreated animals, and between treatments, comparing to both the positive and negative baselines, using multi-dimensional analysis, including side effects.
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Citations
22 Claims
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1. A method for the treatment of a first patient comprising the steps of:
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accepting a first xenograft from a first location in the first patient comprising cells of a first neoplasm; placing in a vivarium a first set of animals in one or more cages; subdividing the first set of animals into one or more subsets; identifying a negative phenotype;
wherein the negative phenotype comprises behaviors and physiological indicators that are consistent with the first set of animals receiving no placement of cells of the first xenograft and no therapeutic treatment;placing at least a portion of the first xenograft in a first location in the brain of each animal (a “
subject animal”
) in the one or more subsets of animals;
wherein the first location in the brain is associated with a first known set of animal behaviors;identifying a positive phenotype, wherein the positive phenotype comprises behaviors and physiological indicators that are compatible unhealthy functioning of the first location of the first organ of the first set of animals; treating each of the one or more subsets with an associated treatment regimen, wherein the associated treatment regimen for each subset is unique; aggregating, measuring and timing one or more phenotype of the one or more subsets of animals, the “
treatment phenotypes”
;comparing the treatment phenotypes of each one or more subsets to both the negative baseline phenotype and the positive baseline phenotype; selecting a regimen responsive to some combination of;
(a) (the least difference between the treatment phenotype and the negative baseline phenotype) and (b) (the largest difference between the treatment phenotype and the set of positive baseline phenotype), for each associated treatment phenotype associated with the regimen; andtreating the first patient with the selected regimen. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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2. The method of claim 2, wherein:
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the subdividing step subdivides the first set of animals into at least two non-overlapping subsets; the treating each of the one or more subsets with an associated treatment regimen uses two or more distinct, associated treatment regimens; and the method further comprises a step of; comparing an efficacy of each of the two or more associated treatment regimens with the other associated treatment regimens wherein the efficacies are responsive to (a) the treatment phenotypes, (b) the negative baseline phenotype, and (c) the positive baseline phenotype.
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Specification