Integrated Waveguide Structure for Fluorescence Analysis
First Claim
1. An integrated waveguide structure, comprising:
- a substrate;
a waveguide layer arranged on top of the substrate, the waveguide layer comprising;
one or more excitation waveguides configured to transmit excitation radiation to activate a fluorescent particle;
one or more emission waveguides distinct from the one or more excitation waveguides, configured to transmit radiation emitted by the fluorescent particle; and
a particle radiation coupler, wherein the particle radiation coupler comprises a resonator element arranged to couple radiation emitted by the fluorescent particle into at least one of the emission waveguides in response to the activation by the excitation radiation transmitted via the one or more excitation waveguides; and
one or more sensing sites configured with respect to the one or more excitation waveguides and the one or more emission waveguides such that a fluorescent particle at one of the sensing sites is activated by the excitation radiation transmitted via the one or more excitation waveguides and radiation emitted by the fluorescent particle is coupled into at least one of the emission waveguides by the particle radiation coupler.
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Abstract
The present disclosure relates to structures, systems, and methods for characterizing one or more fluorescent particles. At least one embodiment relates to an integrated waveguide structure. The integrated waveguide structure includes a substrate. The integrated waveguide structure also includes a waveguide layer arranged on top of the substrate. The waveguide layer includes one or more excitation waveguides, one or more emission waveguides, and a particle radiation coupler, which includes a resonator element. In addition, the integrated waveguide structure includes one or more sensing sites configured with respect to the one or more excitation waveguides and the one or more emission waveguides such that a fluorescent particle at one of the sensing sites is activated by an excitation radiation transmitted via the one or more excitation waveguides and radiation emitted by the fluorescent particle is coupled into at least one of the emission waveguides by the particle radiation coupler.
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Citations
28 Claims
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1. An integrated waveguide structure, comprising:
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a substrate; a waveguide layer arranged on top of the substrate, the waveguide layer comprising; one or more excitation waveguides configured to transmit excitation radiation to activate a fluorescent particle; one or more emission waveguides distinct from the one or more excitation waveguides, configured to transmit radiation emitted by the fluorescent particle; and a particle radiation coupler, wherein the particle radiation coupler comprises a resonator element arranged to couple radiation emitted by the fluorescent particle into at least one of the emission waveguides in response to the activation by the excitation radiation transmitted via the one or more excitation waveguides; and one or more sensing sites configured with respect to the one or more excitation waveguides and the one or more emission waveguides such that a fluorescent particle at one of the sensing sites is activated by the excitation radiation transmitted via the one or more excitation waveguides and radiation emitted by the fluorescent particle is coupled into at least one of the emission waveguides by the particle radiation coupler. - View Dependent Claims (2, 3, 4, 6, 7, 8, 9, 11, 13, 14, 15)
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5. (canceled)
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10. (canceled)
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12. (canceled)
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16. (canceled)
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17. (canceled)
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18. A characterization system for characterizing at least one fluorescent particle, the characterization system comprising:
an integrated waveguide structure, the integrated waveguide structure comprising; a substrate; a waveguide layer arranged on top of the substrate, the waveguide layer comprising; one or more excitation waveguides configured to transmit excitation radiation to activate a fluorescent particle; one or more emission waveguides, distinct from the one or more excitation waveguides, configured to transmit radiation emitted by the fluorescent particle; and a particle radiation coupler, wherein the particle radiation coupler comprises a resonator element arranged to couple radiation emitted by the fluorescent particle into at least one of the emission waveguides in response to the activation by the excitation radiation transmitted via the one or more excitation waveguides; and one or more sensing sites configured with respect to the one or more excitation waveguides and the one or more emission waveguides such that a fluorescent particle at one of the sensing sites is activated by the excitation radiation transmitted via the one or more excitation waveguides and radiation emitted by the fluorescent particle is coupled into at least one of the emission waveguides by the particle radiation coupler; one or more excitation radiation sources configured to transmit the excitation radiation through at least one of the excitation waveguides; and one or more detectors configured to detect radiation transmitted by at least one of the emission waveguides. - View Dependent Claims (19, 21, 22, 23, 24)
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20. (canceled)
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25. (canceled)
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26. A method for characterizing one or more fluorescent particles, the method comprising:
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transmitting excitation radiation into one or more excitation waveguides of an integrated waveguide structure; activating at least one of the fluorescent particles positioned at a sensing site of the integrated waveguide structure, wherein the sensing site is configured such that a fluorescent particle at the sensing site is activated by the excitation radiation transmitted via at least one of the excitation waveguides and radiation emitted by the fluorescent particle is coupled into an emission waveguide of the integrated waveguide structure; coupling radiation emitted by the fluorescent particle to the emission waveguide of the integrated waveguide structure, wherein the emission waveguide is distinct from the excitation waveguides; and detecting radiation emitted by the fluorescent particle and transmitted via the emission waveguide. - View Dependent Claims (27)
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28. (canceled)
Specification