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PHARMACEUTICAL COMPOSITIONS OF THERAPEUTICALLY ACTIVE COMPOUNDS

  • US 20170007661A1
  • Filed: 03/13/2015
  • Published: 01/12/2017
  • Est. Priority Date: 03/14/2014
  • Status: Abandoned Application
First Claim
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1. A method of treating advanced solid tumors in a subject, each characterized by the presence of a mutant allele of IDH1, the method comprising administering to the subject in need thereof a pharmaceutical composition comprising:

  • (a) a compound (S)—

    N—

    ((S)-1-(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide (Compound

         1), or a pharmaceutically acceptable salt thereof, as part of a solid dispersion;

    Form 1 of the Compound 1;

    or Form 2 of the Compound 1; and

    optionally (b) one or more pharmaceutically acceptable carrier(s).

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