INTRINSIC FREQUENCY HEMODYNAMIC WAVEFORM ANALYSIS

• US 20170014039A1
• Filed: 09/27/2016
• Published: 01/19/2017
• Est. Priority Date: 12/22/2011
• Status: Abandoned Application

• Current Assignee: California Institute of Technology
• Original Assignee: California Institute of Technology
• Inventors: Pahlevan, Niema, Tavallali, Peyman, Hou, Thomas Yizhao, Gharib, Morteza
• Application Number:
  US15/277,672
• Publication Number:
  US 20170014039A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61B 5/0004 characterised by the type of physiological signal transmitted
• CPC Class Codes: A61B 5/0013 Medical image data A61B1/00011, A61B6/56, A61B8/56 take precedence
• CPC Class Codes: A61B 5/0077 Devices for viewing the surface of the body, e.g. camera, magnifying lens
• CPC Class Codes: A61B 5/02028 Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction
• CPC Class Codes: A61B 5/02405 Determining heart rate variability
• CPC Class Codes: A61B 5/02416 using photoplethysmograph signals, e.g. generated by infrared radiation A61B5/14552 takes precedence
• CPC Class Codes: A61B 5/02438 with portable devices, e.g. worn by the patient
• CPC Class Codes: A61B 5/0507 using microwaves or terahertz waves
• CPC Class Codes: A61B 5/7235 Details of waveform analysis A61B5/349 takes precedence
• CPC Class Codes: A61B 5/7278 Artificial waveform generation or derivation, e.g. synthesising signals from measured signals A61B5/327 takes precedence
• CPC Class Codes: A61B 5/7282 Event detection, e.g. detecting unique waveforms indicative of a medical condition A61B5/4094, A61B5/4818, A61B5/349, A61B5/0823 take precedence
• CPC Class Codes: A61B 5/746 Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms alarms per se G08B
• CPC Class Codes: A61B 8/02 Measuring pulse or heart rate
• CPC Class Codes: A61B 8/06 Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00
• CPC Class Codes: A61B 8/5223 for extracting a diagnostic or physiological parameter from medical diagnostic data for algorithms to analyse biomedical images G06T7/0012
• CPC Class Codes: A61B 8/565 involving data transmission via a network

Abstract

Hardware and software methodology are described for cardiac health measurement. Hemodynamic waveforms variously acquired for a subject are analyzed to calculate or approximate intrinsic frequencies in two domains in two domains across the Dicrotic Notch. The intrinsic frequencies provide metrics/ measures that correlate to the cardiac health of the subject. The systems may be used for monitoring a condition and/or is diagnosis. Exemplary uses include identifying (diagnosing) the presence of arrhythmia, heat failure, atrial fibrillation, aneurysms, vessel stenosis or aortic valve dysfunction and the necessity for valve replacement and/or monitoring congestive heart failure progression, together with identifying the acute need for hospitalization in connection with daily testing for any such condition.

Claims

1. A system for acquiring and analyzing a hemodynamic waveform of a subject, the system comprising:

an optical scanner, the scanner adapted to capture a signal corresponding to a hemodynamic waveform; and

at least one computer processor connected to the scanner by a wired or wireless connection, wherein the computer processor is adapted to receive the signal for the hemodynamic waveform, determine a Dicrotic Notch using the signal, calculate first and second intrinsic frequencies (ω

₁, ω

₂) on each side of the Dicrotic Notch for the waveform, and output a signal corresponding to intrinsic frequencies results.

2. A computer-implemented method of analyzing a signal, comprising:

inputting a hemodynamic waveform data for a subject, the waveform including a Dicrotic Notch;

determining a position of the Dicrotic Notch in the waveform for dividing the signal into first and second sections for analysis;

analyzing each of the first and second sections of the waves by to determine first and second intrinsic frequencies (ω

₁, ω

₂) where each intrinsic frequency is at or about a frequency that carries the highest energy for all frequencies of an instantaneous frequency curve; and

outputting a result of the analyzing.