SYSTEM AND METHOD FOR A DRUG DELIVERY AND BIOSENSOR PATCH

• US 20170014572A1
• Filed: 09/26/2016
• Published: 01/19/2017
• Est. Priority Date: 07/19/2015
• Status: Active Grant

• Current Assignee: Trilinear Bioventures LLC
• Original Assignee: Sanmina-SCI Corporation
• Inventors: Rodencal, Matthew, Newberry, Robert Steven
• Granted Patent: US 9,636,457 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61M 2205/3306 Optical measuring means
• CPC Class Codes: A61M 2205/3584 using modem, internet or bluetooth
• CPC Class Codes: A61M 2205/502 User interfaces, e.g. screens or keyboards
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: A61M 2205/8206 battery-operated
• CPC Class Codes: A61M 2205/8268 Fuel storage cells
• CPC Class Codes: A61M 2230/06 Heartbeat rate only
• CPC Class Codes: A61M 2230/20 Blood composition characteristics
• CPC Class Codes: A61M 2230/30 Blood pressure A61M2230/04 takes precedence
• CPC Class Codes: A61M 2230/42 Rate
• CPC Class Codes: A61M 2230/50 Temperature
• CPC Class Codes: A61M 2230/63 Motion, e.g. physical activity
• CPC Class Codes: A61M 5/14248 of the skin patch type
• CPC Class Codes: A61M 5/145 using pressurised reservoirs, e.g. pressurised by means of pistons
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: A61M 5/3298 Needles arranged in parallel

Abstract

An integrated drug delivery and biosensor (IDDB) system is implemented on a patch or arm band. The drug delivery system includes needles adapted to pierce the skin and direct injection of a predetermined dosage of medication through the needles into the epidermis of the skin of a patient. The integrated biosensor monitors absorption of the medication into the epidermis of the skin of the patient and may also monitor concentration of the medication or other relevant substances in arterial blood flow of the patient. The integrated biosensor may also monitor a patient'"'"'s vitals in response to the medication. The integrated biosensor may then alter dosage or frequency of administration of dosages or even halt a dosage of medication in response to the patient'"'"'s vitals or absorption of the medication.

Claims

1. An integrated drug delivery and biosensor (IDDB) system, comprising:

a patch configured for attaching to a patient;

a drug delivery system coupled to the patch, wherein the drug delivery system is configured to administer a dosage of medication at an administration rate to the patient;

a biosensor system coupled to the patch, wherein the biosensor system is configured to;

monitor biosensor data of the patient, wherein the biosensor data includes one or more of;

respiratory rate, heart rate or blood pressure;

monitor absorption rate of the medication into one or more of;

surrounding tissue or arterial blood flow; and

monitor concentration of a substance in one or more of;

surrounding tissue or arterial blood flow;

wherein the drug delivery system is configured to alter at least one of the dosage of the medication or the administration rate of the medication in response to the biosensor data.

2. The IDDB system of claim 1, wherein the drug delivery system includes one or more needles and is configured to administer the dosage of the medication at the administration rate through the one or more needles into at least an upper epidermal layer of the skin.

3. The IDDB system of claim 1, wherein the biosensor system is further configured to:

determine one or more of;

respiratory rate, heart rate or blood pressure has exceeded a predetermined threshold indicating an allergic reaction; and

transmit instructions to the drug delivery system to halt the administration of the dosage of the medication.

4. The IDDB system of claim 1, wherein the biosensor includes at least a photoplethysmograpy (PPG) circuit, wherein the PPG circuit includes:

a light source configured to emit light directed at skin of the patient at a plurality of frequencies;

a photodetector circuit configured to detect spectral responses of reflected light from the skin and surrounding tissue at the plurality of frequencies; and

a processing circuit configured to;

process the spectral responses at the plurality of frequencies; and

obtain a concentration level of at least one substance in arterial blood flow of the patient.

5. The IDDB system of claim 4, wherein the drug delivery system is configured to alter at least one of the dosage of the medication or the administration rate of the medication or frequency of dosage of the medication in response to the concentration level of the at least one substance in the arterial blood flow of the patient.

6. The IDDB system of claim 4, wherein the processing circuit is configured to process the spectral responses at the plurality of wavelengths by:

isolating a systolic point and a diastolic point in a first spectral response and obtain a value L<sub>λ

1</sub> using a ratio of the systolic point and the diastolic point in the first spectral response;

isolating a systolic point and a diastolic point in a second spectral response and obtain a value L<sub>λ

2</sub> using a ratio of the systolic point and diastolic point in the second spectral response; and

obtaining a value R<sub>λ

1,λ

2</sub> from a ratio of the value L<sub>λ

1</sub> and the value L<sub>λ

2</sub>.

7. The IDDB system of claim 1, wherein the biosensor includes at least a PPG circuit, wherein the PPG circuit includes:

a light source configured to emit light directed at skin of the patient at a plurality of frequencies;

a photodetector circuit configured to detect spectral responses of reflected light from the skin and surrounding tissue at the plurality of frequencies; and

a processing circuit configured to;

process the spectral response at a plurality of frequencies; and

obtain an absorption rate of the medication using the spectral response.

8. The IDDB system of claim 7, wherein the drug delivery system is configured to alter at least one of the dosage of the medication or the administration rate of the medication or frequency of dosage of the medication in response to absorption rate of the medication.

9. The IDDB system of claim 1, wherein the IDDB system is further configured to:

obtain at least one of;

position information and activity level; and

adjust operation of at least one of the biosensor system or the drug delivery system in response to at least one of the position information or the activity level.

10. The IDDB system 100 of claim 1, further comprising:

a wireless transceiver coupled to the patch for transmitting biosensor data and the dosage and the administration rate of the medication to one or more devices in an EMR network.

18. The IDDB system 100 of claim 1, further comprising:

a wireless transceiver coupled to the patch for transmitting biosensor data and the dosage and the administration rate of the medication to one or more devices in an EMR network.

11. An integrated drug delivery and biosensor (IDDB) system, comprising:

a patch configured for attaching to a patient;

a drug delivery system coupled to the patch, wherein the drug delivery system is configured to administer medication to the patient;

a biosensor coupled to the patch, wherein the biosensor is configured to;

monitor biosensor data of the patient, wherein the biosensor data includes one or more of;

respiratory rate, heart rate or blood pressure;

monitor concentration of a substance in one or more of;

surrounding tissue or arterial blood flow;

determine when one or more predetermined thresholds are detected in the biosensor data of the patient or the concentration of the substance; and

transmit instructions to the drug delivery system to administer a dosage of the medication in response to the biosensor data.

12. The IDDB system of claim 11, wherein the biosensor is further configured to monitor absorption rate of the medication into one or more of:

surrounding tissue or arterial blood flow.

13. The IDDB system of claim 12, wherein the drug delivery system is configured to alter at least one of the dosage of the medication or the administration rate of the medication or frequency of dosage of the medication in response to the absorption rate of the medication.

14. The IDDB system of claim 11, wherein the biosensor includes at least a photoplethysmograpy (PPG) circuit, wherein the PPG circuit includes:

a light source configured to emit light directed at skin of the patient at a plurality of frequencies;

a photodetector circuit configured to detect spectral responses of reflected light from the skin and surrounding tissue at the plurality of frequencies; and

a processing circuit configured to;

process the spectral responses at the plurality of frequencies; and

obtain a concentration level of at least one substance in arterial blood flow of the patient.

15. The IDDB system of claim 14, wherein the processing circuit is configured to process the spectral responses at the plurality of wavelengths by:

isolating a systolic point and a diastolic point in a first spectral response and obtain a value L<sub>λ

1</sub> using a ratio of the systolic point and the diastolic point in the first spectral response;

isolating a systolic point and a diastolic point in a second spectral response and obtain a value L<sub>λ

2</sub> using a ratio of the systolic point and diastolic point in the second spectral response; and

obtaining a value R<sub>λ

1,λ

2</sub> from a ratio of the value L<sub>λ

1</sub> and the value L<sub>λ

2</sub>.

16. The IDDB system of claim 11, wherein the drug delivery system includes one or more needles and is configured to administer the dosage of the medication at the administration rate through the one or more needles into at least an upper epidermal layer of the skin.

17. The IDDB system of claim 11, wherein the IDDB system is further configured to:

obtain at least one of;

position information and activity level; and

adjust operation of at least one of the biosensor system or the drug delivery system in response to at least one of the position information or the activity level.

19. An integrated drug delivery and biosensor (IDDB) system, comprising:

a patch configured for attaching to a patient;

a drug delivery system coupled to the patch, wherein the drug delivery system is configured to administer medication to the patient;

a biosensor coupled to the patch, wherein the biosensor includes;

a light source configured to emit light directed at skin of the patient at a plurality of frequencies;

a photodetector circuit configured to detect spectral responses of reflected light from the skin and surrounding tissue at the plurality of frequencies; and

a processing circuit configured to;

process the spectral responses at the plurality of frequencies; and

obtain a concentration level of at least one substance in arterial blood flow of the patient using the spectral responses at the plurality of frequencies;

determine an absorption rate of the medication in surrounding tissue of the patient using the spectral responses at the plurality of frequencies; and

determine when one or more predetermined thresholds are detected in the biosensor data of the patient or the concentration of the substance; and

transmit instructions to the drug delivery system to administer a dosage of the medication in response to the biosensor data.

20. The IDDB system of claim 19, wherein the biosensor is further configured to:

determine one or more of;

respiratory rate, heart rate or blood pressure has exceeded a predetermined threshold indicating an allergic reaction; and

transmit instructions to the drug delivery system to halt the administration of the dosage of the medication.