SYSTEM AND METHODS FOR WIRELESS DRUG DELIVERY ON COMMAND
First Claim
1. A method for fabricating a miniaturized implantable device:
- fabricating an electronic system by monolithically integrating the electronic system on a first face of a substrate, the electronic system comprising an energy storage element adapted to be charged through a wireless communication link;
fabricating a coil by monolithically integrating the coil on the first face of the substrate, the coil being configured to provide the wireless communication link; and
fixating at least one hermetic package, containing a liquid payload, on the first surface of the substrate, a portion of the hermetic package being positioned above the coil,wherein the energy storage element is configured to provide energy to rupture a seal of the hermetic package, thereby dispensing the liquid payload.
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Accused Products
Abstract
A fully integrated small size implantable sensing device is described, which can include a sensor and an electronic circuit to interface with the sensor and communicate with an external device. Various fabrication methods for the sensing device are described, including provision of wells, created using same fabrication technology as the electronic circuit, to contain electrodes of the sensor and corresponding functionalization chemicals. Such implantable sensing device can be used for a variety of electrochemical measuring applications within a living body as well as actuation by injecting a current into the living body.
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Citations
31 Claims
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1. A method for fabricating a miniaturized implantable device:
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fabricating an electronic system by monolithically integrating the electronic system on a first face of a substrate, the electronic system comprising an energy storage element adapted to be charged through a wireless communication link; fabricating a coil by monolithically integrating the coil on the first face of the substrate, the coil being configured to provide the wireless communication link; and fixating at least one hermetic package, containing a liquid payload, on the first surface of the substrate, a portion of the hermetic package being positioned above the coil, wherein the energy storage element is configured to provide energy to rupture a seal of the hermetic package, thereby dispensing the liquid payload. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. An integrated miniaturized implantable device comprising:
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a substrate for monolithic integration comprising a plurality of metal layers separated via a plurality of insulating layers; a monolithically integrated electronic system comprising an energy storage element adapted to be charged through a wireless communication; a monolithically integrated coil configured to provide the wireless communication link; and a hermetic package, containing a liquid payload, fixated on the substrate, a portion of the hermetic package being positioned above the coil, wherein during operation of the implantable device, the electronic system is configured to; communicate with an external device over the wireless communication link provided by the coil, extract power for the miniaturized implantable device from the wireless communication link, charge the energy storage element based on the extracted power, and energize an actuator via the energy storage element to rupture a seal of the hermetic package. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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Specification