Method of Forming a Drug-Eluting Medical Device

• US 20170020700A1
• Filed: 08/01/2016
• Published: 01/26/2017
• Est. Priority Date: 09/17/2010
• Status: Abandoned Application

• Current Assignee: Medtronic Vascular, Inc. (Medtronic Plc)
• Original Assignee: Medtronic Vascular, Inc. (Medtronic Plc)
• Inventors: Bienvenu, Ryan, Kantor, John
• Application Number:
  US15/224,897
• Publication Number:
  US 20170020700A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61F 2/86 Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2/88 the wire-like elements formed as helical or spiral coils forming a net-like or mesh-like structure A61F2/90
• CPC Class Codes: A61F 2/89 the wire-like elements comprising two or more adjacent rings flexibly connected by separate members
• CPC Class Codes: A61F 2230/0069 cylindrical
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61F 2250/0068 the pharmaceutical product being in a reservoir
• CPC Class Codes: A61L 2400/18 Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
• CPC Class Codes: A61L 31/022 Metals or alloys
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61M 2207/10 Device therefor
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50
• CPC Class Codes: B23P 19/04 for assembling or disassembling parts
• CPC Class Codes: C23F 1/12 Gaseous compositions
• CPC Class Codes: Y10T 29/4987 Elastic joining of parts

Abstract

A method of forming a stent includes the steps of forming a composite member into a stent pattern, forming openings through an outer member of the composite member, processing the composite member to remove a portion of the composite member without adversely affecting the outer member, and swaging the outer member to create a plurality of lumens. The composite member may be formed of an outer member with an hourglass-shaped inner member, wherein the processing step removes the inner member and the swaging step forms two lumens from the hourglass shaped cavity. The composite member may be formed of an outer member, an inner member, and an intermediate member, wherein the processing step removes the intermediate member and the swaging step presses portions of the outer member into contact with the inner member to form two lumens separated by the inner member.

Claims

1-25. -25. (canceled)

26. A method of forming a stent comprising the steps of:

utilizing a wire having an outer member and an internal support structure dividing an internal lumen of the wire into a plurality of lumens;

shaping the wire into a stent pattern;

forming openings through the outer member to at least one of the lumens; and

filling the plurality of lumens with at least one biologically or pharmacologically active substance.

27. The method of claim 26, wherein the internal support structure is formed from portions of the outer member.

28. The method of claim 26, wherein the plurality of lumens are similarly shaped.

29. The method of claim 26, wherein at least two of the plurality of lumens are shaped differently from each other.

30. The method of claim 26, wherein the internal support structure is a honeycomb shaped structure forming the plurality of internal lumens.

31. The method of claim 30 further comprising at least one opening through at least one wall of the honeycomb structure so as to permit the at least one biologically or pharmacologically active substance to move between at least one internal lumen to at least one opening through the outer member.

32. The method of claim 26, further comprising the step of filling a first lumen with a first biologically or pharmacologically active substance and filling a second lumen with a second biologically or pharmacologically active substance, wherein the first and second biologically or pharmacologically active substances are different.

33. The method of claim 32, wherein the first and second biologically or pharmacologically active substances are selected from the group consisting of antineoplastic, antimitotic, antiinflammatory, antiplatelet, anticoagulant, anti fibrin, antithrombin, antiproliferative, antibiotic, antioxidant, and antiallergic substances as well as combinations thereof.