SYSTEM & METHOD FOR ESTIMATING SUBSTANCE CONCENTRATIONS IN BODILY FLUIDS

• US 20170027486A1
• Filed: 04/07/2015
• Published: 02/02/2017
• Est. Priority Date: 04/07/2014
• Status: Abandoned Application

• Current Assignee: City University
• Original Assignee: City University
• Inventors: Qassem, Meha, Constantinou, Loukas, Kyriacou, Panayiotis, Triantis, Iasonas, Hickey, Michelle
• Application Number:
  US15/302,784
• Publication Number:
  US 20170027486A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61B 2562/0238 Optical sensor arrangements for performing transmission measurements on body tissue
• CPC Class Codes: A61B 2562/063 in a linear array
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/0537 Measuring body composition by impedance, e.g. tissue hydration or fat content
• CPC Class Codes: A61B 5/063 using impedance measurements
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/1477 non-invasive
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61B 5/165 Evaluating the state of mind, e.g. depression, anxiety
• CPC Class Codes: A61B 5/742 using visual displays A61B5/339 takes precedence

Abstract

One implementation described herein includes a system for providing at least an estimate of substance concentrations in a bodily fluid. The system comprises a first emitter for generating signals using a first sensing modality, a first detector configured to detect signals from said first emitter that have travelled through the bodily fluid and output a corresponding first detector signal; a second emitter for generating signals using a second sensing modality different to said first sensing modality, a second detector configured to detect signals from said second emitter that have travelled through the bodily fluid and output a corresponding second detector signal; and a processor configured to receive the detector signals from said first and second detectors, to process said signals and to output an indication of at least an estimate of the concentration of said substance in said bodily fluid.

Claims

1. A system for providing at least an estimate of substance concentrations in a bodily fluid, the system comprising:

a first emitter for generating signals using a first sensing modality,

a first detector configured to detect signals from said first emitter that have travelled through the bodily fluid and output a corresponding first detector signal;

a second emitter for generating signals using a second sensing modality different to said first sensing modality,

a second detector configured to detect signals from said second emitter that have travelled through the bodily fluid and output a corresponding second detector signal; and

a processor configured to receive the detector signals from said first and second detectors, to process said signals and to output an indication of at least an estimate of the concentration of said substance in said bodily fluid.

2. The system according to claim 1, comprising a control module, and a probe coupled to the control module for communication therewith.

3. The system according to claim 2, wherein the control module comprises a display controllable by the processor to display an indication of at least an estimate of the concentration of said substance in said bodily fluid.

4. The system according to claim 3, wherein said indication is coloured and the colour of said indication varies with estimated substance concentrations.

5. The system according to claim 3, wherein said indication is text-based, the text varying with variations in estimated substance concentrations.

6. The system according to claim 2, wherein the control module and probe are wirelessly coupled to one another.

7. The system according to claim 2, wherein the control module is hand-holdable and portable.

8. The system according to claim 2, wherein the probe comprises the first and second emitters and the first and second detectors.

9. The system according to claim 8, wherein said probe is configured to be adhered or otherwise affixed to a subject.

10. The system according to claim 1, wherein said first sensing modality comprises an optical sensing modality.

11. The system according to claim 10, wherein said first emitter is operable to emit light of one or more wavelengths.

12. The system according to claim 11, wherein said first emitter is operable to emit light at a plurality of wavelengths.

13. The system according to claim 12, wherein said first emitter comprises at least a first and a second LED.

14. The system according to claim 10, wherein said first detector signal is representative of the intensity of light received from said first emitter.

15. The system according to claim 1 wherein said second sensing modality comprises an electrical sensing modality.

16. The system according to claim 15, wherein said second emitter comprises a plurality of electrical contacts.

17. The system according to claim 15, wherein said system is configured to apply a current to a bodily fluid at one or a plurality of frequencies.

18. The system according to claim 15, wherein said second detector signal is representative of the impedance of the bodily fluid.

19. The system according to claim 1, wherein said processor is provided with a calibration model configured to output an estimate of substance concentration when the model is provided with said first and second detector signals.

20. The system according to claim 1, wherein said substance comprises lithium.

21. A method for providing at least an estimate of substance concentrations in a bodily fluid, the method comprising:

operating a first emitter to generate signals using a first sensing modality, operating a first detector to detect signals from said first emitter that have travelled through the bodily fluid, and outputting a corresponding first detector signal;

operating a second emitter to generate signals using a second sensing modality different to said first sensing modality,

operating a second detector to detect signals from said second emitter that have travelled through the bodily fluid, and outputting a corresponding second detector signal; and

providing a processor that is configured to receive the detector signals from said first and second detectors, and operating said processor to process said signals and to output an indication of at least an estimate of the concentration of said substance in said bodily fluid.