Trk-INHIBITING COMPOUND

• US 20170027939A1
• Filed: 10/12/2016
• Published: 02/02/2017
• Est. Priority Date: 02/19/2013
• Status: Active Grant

• Current Assignee: ONO Pharmaceutical Company Limited
• Original Assignee: ONO Pharmaceutical Company Limited
• Inventors: TAKEUCHI, Jun, ITADANI, Satoshi, HASHIMURA, Kazuya, IKURA, Masahiro, HIGASHINO, Masato, YASUHIRO, Tetsuya, NAGAURA, Takeshi
• Granted Patent: US 9,763,943 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61K 31/136 having the amino group directly attached to the aromatic ring, e.g. benzeneamine
• CPC Class Codes: A61K 31/444 containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
• CPC Class Codes: A61K 31/506 not condensed and containing further heterocyclic rings
• CPC Class Codes: A61K 31/519 ortho- or peri-condensed with heterocyclic rings
• CPC Class Codes: A61K 31/5377 not condensed and containing further heterocyclic rings, e.g. timolol
• CPC Class Codes: A61K 31/663 Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: C07D 213/75 Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
• CPC Class Codes: C07D 239/47 One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
• CPC Class Codes: C07D 401/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 401/14 containing three or more hetero rings
• CPC Class Codes: C07D 405/14 containing three or more hetero rings
• CPC Class Codes: C07D 409/14 containing three or more hetero rings
• CPC Class Codes: C07D 471/04 Ortho-condensed systems
• CPC Class Codes: C07D 487/04 Ortho-condensed systems
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The present invention provides a drug containing a compound having Trk-inhibiting activity as an active ingredient in prophylaxis and/or therapy for Trk-related diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease. A compound represented by the general formula (I), wherein all symbols represent the same meanings as described in the specification, a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof is useful as a drug component having Trk-inhibiting activity in prophylaxis and/or therapy of diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease.

Claims

1. A method for prophylaxis and/or treatment of pain comprising,

administering to a patient an effective amount of 1-(2-(4-(2-amino-5-fluoropyridin-3-yl)phenoxy)pyrimidin-5-yl)-3-(2-(pyridin-3-yl)-5-(trifluoromethyl)phenyl)urea or a salt thereof.

2. The method according to claim 1, wherein the pain is selected from the group consisting of pain of osteoarthritis, cancer pain, chronic low back pain, low back pain of osteoporosis, pain of bone fracture, pain of rheumatoid arthritis, neuropathic pain, postherpetic pain, pain of diabetic neuropathy, fibromyalgia, pain of pancreatitis, pain of interstitial cystitis, pain of endometriosis, pain of irritable bowel syndrome, migraine, postoperative pain and pain of pulpitis.

3. The method according to claim 1, wherein the pain is pain of osteoarthritis.

4. The method according to claim 1, wherein the pain is cancer pain.

5. The method according to claim 1, wherein the pain is chronic low back pain.

6. The method according to claim 1, wherein the pain is low back pain of osteoporosis.

7. The method according to claim 1, wherein the pain is pain of bone fracture.

8. The method according to claim 1, wherein the pain is pain of rheumatoid arthritis.

9. The method according to claim 1, wherein the pain is neuropathic pain.

10. The method according to claim 1, wherein the pain is postherpetic pain.

11. The method according to claim 1, wherein the pain is pain of diabetic neuropathy.

12. The method according to claim 1, wherein the pain is fibromyalgia.

13. The method according to claim 1, wherein the pain is pain of pancreatitis.

14. The method according to claim 1, wherein the pain is pain of interstitial cystitis.

15. The method according to claim 1, wherein the pain is pain of endometriosis.

16. The method according to claim 1, wherein the pain is pain of irritable bowel syndrome.

17. The method according to claim 1, wherein the pain is migraine.

18. The method according to claim 1, wherein the pain is postoperative pain.

19. The method according to claim 1, wherein the pain is pain of pulpitis.