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CHIRAL DESIGN

  • US 20170037399A1
  • Filed: 01/16/2015
  • Published: 02/09/2017
  • Est. Priority Date: 01/16/2014
  • Status: Active Grant
First Claim
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1. A chirally controlled oligonucleotide composition comprising oligonucleotides of a particular oligonucleotide type characterized by:

  • 1) a common base sequence and length;

    2) a common pattern of backbone linkages; and

    3) a common pattern of backbone chiral centers,which composition is chirally controlled in that it is enriched, relative to a substantially racemic preparation of oligonucleotides having the same base sequence and length, for oligonucleotides of the particular oligonucleotide type;

    wherein;

    the common base sequence has at least 17 bases;

    orthe single oligonucleotide comprises 11 or more chiral, modified phosphate linkages.

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