FUNCTIONAL CONTACT LENS AND RELATED SYSTEMS AND METHODS

• US 20170042480A1
• Filed: 04/15/2015
• Published: 02/16/2017
• Est. Priority Date: 04/15/2014
• Status: Abandoned Application

• Current Assignee: Medella Health Inc.
• Original Assignee: Medella Health Inc.
• Inventors: Gandhi, Harry, Gao, Huayi, Baig, Maarij, Chen, Ray
• Application Number:
  US15/304,352
• Publication Number:
  US 20170042480A1
• Time in Patent Office: Days
• CPC Class Codes: A61B 2560/0214 of power generation or supply
• CPC Class Codes: A61B 2562/245 Means for cleaning the sensor in-situ or during use, e.g. hygienic wipes
• CPC Class Codes: A61B 3/101 for examining the tear film
• CPC Class Codes: A61B 3/16 for measuring intraocular pressure, e.g. tonometers
• CPC Class Codes: A61B 5/0015 characterised by features of the telemetry system
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61B 5/14507 specially adapted for measuring characteristics of body fluids other than blood devices for taking samples of body liquids A61B10/0045
• CPC Class Codes: A61B 5/1451 for interstitial fluid
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1468 using chemical or electrochemical methods, e.g. by polarographic means A61B5/1486 takes precedence
• CPC Class Codes: A61B 5/6821 Eye
• CPC Class Codes: A61B 5/742 using visual displays A61B5/339 takes precedence
• CPC Class Codes: G02C 7/04 Contact lenses for the eyes disinfection or sterilisation of contact lenses A61L12/00

Abstract

Various embodiments are described herein for a Functional Contact Lens (FCL) for detecting at least one target analyte. The FCL may comprise a substrate for supporting electronic components and providing structural support for the functional contact lens; at least one sensing element disposed on the substrate for sensing the at least one target analyte and undergoing a physical change representing a sensed signal; and an antenna disposed on the substrate for transmitting the sensed signal to an external device, the antenna being coupled to the at least one sensing element.

Claims

1. A functional contact lens for detecting at least one target analyte, comprising:

a substrate for supporting electronic components and providing structural support for the functional contact lens;

at least one sensing element disposed on the substrate for sensing the at least one target analyte and undergoing a physical change representing a sensed signal;

a disintegration layer for covering the at least one sensing element, the disintegration layer being configured to disintegrate during use to allow for operation of the at least one sensing element; and

an antenna disposed on the substrate for transmitting the sensed signal to an external device, the antenna being coupled to the at least one sensing element.

2. The functional contact lens of claim 1, wherein the at least one sensing element undergoes an impedance change when sensing the at least one target analyte, the sensed signal causing a change in a resonance frequency or a change in amplitude of an output signal transmitted by the antenna due to the impedance change of the sensing element.

3. The functional contact lens of claim 2, further comprising an impedance matching element coupled to the antenna for providing impedance matching and compensation of the antenna.

4. The functional contact lens of claim 2, further comprising a second sensing element coupled to the antenna and being configured to undergo an impedance change upon sensing a second target analyte thereby generating another change in a resonance frequency or a change in amplitude of the output signal transmitted by the antenna.

5. The functional contact lens of claim 1, wherein the functional contact lens has a chip-less design.

6. The functional contact lens of claim 1, further comprising:

a main circuit for controlling the operation of the functional contact lens;

a sensing module comprising a plurality of sensing elements for sensing the at least one target analyte during use; and

a modular sensor interface for coupling the main circuit to the sensing module.

7. The functional contact lens of claim 6, wherein the main circuit and the modular sensor interface are implemented using separate Application Specific Integrated Circuits (ASICs) or a common ASIC.

8. The functional contact lens of claim 6, wherein the sensing elements are electrochemical or biochemical sensors.

9. The functional contact lens of claim 8, wherein the biochemical sensors use single strain DNA based detection or antibody based detection.

10. The functional contact lens of claim 6, wherein the main circuit comprises:

the antenna;

a communication module for receiving signals from the external device and transmitting signals to the external device; and

a power module for providing power to components of the functional contact lens requiring power for operation.

11. The functional contact lens of claim 6, wherein the antenna has an annular shape and is disposed along a first annular section of the functional contact lens having a first radius, the sensing elements are disposed along a second annular section of the functional contact lens having a second radius less than the first radius and interconnects are disposed along a third annular section of the functional contact lens between the first and second annular sections to couple the sensing elements with the main circuit, wherein the annular shapes, annular sections and peripheral edge of the functional contact lens are all either circular or oval.

12. The functional contact lens of claim 11, wherein interconnects are disposed between the sensing elements to allow the sensing elements to share one or more electrodes.

13. The functional contact lens of claim 1, wherein the functional contact lens comprises:

a first member having an annular shape and disposed at an outer periphery of the contact lens;

a second member having a disc shape and disposed within and adjacent to the first member, and

the substrate which has a disc shape with a smaller circumference than the second member and is disposed on the second member,

wherein the annular and disc shapes are all either circular or oval.

14. The functional contact lens of claim 13, wherein at least one of the first and second members are made using a gas permeable contact lens material for users who wear the functional contact lens when sleeping.

15. The functional contact lens of claim 13, wherein at least one of the first and second members are made using a soft hydrogel contact lens material having a high water content for users who wear the functional contact lens during daytime.

16. The functional contact lens of claim 1, further comprising:

an insulation layer covering at least a portion of the electronic components disposed on the substrate to provide protection;

a screening layer disposed on the at least one sensing element to provide selective interaction of the at least one sensing element with its environment; and

an encapsulation layer disposed over the insulation layer and the screening layer and portion of the electronic components, the encapsulation layer being configured to comprise selectively allows for diffusion of certain biomolecules towards the substrate.

17. The functional contact lens of claim 16, wherein the at least one sensing element comprises a biochemical sensor and the screening layer is configured to allow for selective transmission of certain biochemicals to the biochemical sensor during use.

18. The functional contact lens of claim 16, further comprising at least one optical element disposed on the substrate and the screening layer covers the at least one optical element and is configured to allow certain target photons at certain wavelengths to pass therethrough to the at least one optical element.

19. The functional contact lens of claim 18, wherein the disintegration layer covers the at least one optical element, the disintegration layer being configured to disintegrate during use to allow for operation of the at least one optical element.

20. The functional contact lens of claim 19, wherein the disintegration layer is configured to disintegrate during use due to electrical stimulation or naturally occurring biochemically active species present in a surrounding fluid.

21. The functional contact lens of claim 19, further comprising multiple similar sensing elements and sensing lifetime is prolonged by configuring the disintegration layer to disintegrate over a subsequent sensing element after a previous operational sensing element stops functioning or is performing poorly.

22. The functional contact lens of claim 19, wherein the disintegration layer is configured for timed activation of at least one of selected sensing elements and selected optical elements for sequential, parallel or sequential and parallel operation thereof.

23. The functional contact lens of claim 18, wherein the at least one optical element comprises at least one of reflection pixel matrices, transmission pixel matrices, Light Emitting Diodes (LEDs) and Organic Light Emitting Diodes (OLEDs), Liquid Crystal Display (LCD), surface plasmonic resonators, and photonic crystals.

24. The functional contact lens of claim 18, wherein an absorption spectrum of the at least one optical element is electrically controlled to produce desirable wavelengths of photons that are reflected or transmitted upon incidence with the at least one optical element.

25. The functional contact lens of claim 10, wherein the power module comprises:

a rectifier for converting harvested energy conditioning the stored energy to provide power;

an energy storage unit for storing converted harvested energy for use by electronic components of the functional contact lens; and

at least one energy harvesting element comprising at least one of one or more fuel cells, one or more solar cells and one or more piezoelectric cells.

26. The functional contact lens of claim 25, wherein the one or more piezoelectric cells comprise one of micro-pillars and nano-pillars that create a piezoelectric potential upon mechanical deformation.

27. The functional contact lens of claim 1, wherein the at least one sensing element is coupled with a sensor interface for receiving an input signal and providing an output signal, the at least one sensing element comprising:

a working electrode having an annular shape; and

a second electrode having an annular shape with a larger radius that surrounds a majority of the working electrode, the second electrode being configured to operate as a counter electrode or a reference electrode.

28. The functional contact lens of claim 1, wherein the at least one sensing element is coupled with a sensor interface for receiving an input signal and providing an output signal, the at least one sensing element comprising:

a working electrode having an annular shape;

a counter electrode having an annular shape that surrounds a majority of the working electrode; and

a reference electrode having an annular shape that surrounds the counter electrode.

29. The functional contact lens of claim 28, wherein the reference electrode comprises two electrodes having semi-annual shapes disposed on either side of the counter electrode.

30. The functional contact lens of claim 28, wherein the at least one sensing element comprises a fourth electrode disposed within the annular shape of the working electrode, the fourth electrode being configured to provide at least one of a modulating function and a cleansing function of a microenvironment of the working electrode.

31. The functional contact lens of claim 28, wherein the at least one sensing element comprises a modulating electrode and a cleansing electrode that are both disposed within the annular shape of the working electrode and being configured to provide a modulating function and a cleansing function, respectively, of a microenvironment of the working electrode.

32. The functional contact lens of claim 27, wherein the working electrode is interdigitated.

33. The functional contact lens of claim 27, wherein the input signal and the output signal are at least one of a constant DC voltage, a constant DC current, a step-up DC voltage, a step-up DC current, a sinusoidal AC voltage with a certain radial frequency and amplitude, a sinusoidal AC current with a certain radial frequency and amplitude, a square wave AC voltage, and a square wave AC current pulse.

34. The functional contact lens of claim 1, wherein the at least one target analyte comprises at least one of acids, ions, carbonhydrate, proteins, enzymes, lipids, antigens, hormones, nucleic acids, small molecules, medications and recreational drugs.

35. The contact lens of claim 1, wherein the substrate has an annular or wedge shape.

36. A system for monitoring a person'"'"'s health, wherein the system comprises:

a Functional Contact Lens (FCL) that monitors at least one condition for the person, the FCL comprising at least one sensing element to monitor the at least one condition and a disintegration layer that covers the at least one sensing element and is configured to disintegrate during use to allow for operation of the at least one sensing element;

a transceiver-reader device that communicates with the FCL; and

an external processing device,

wherein the transceiver-reader device acts as a relay device in sending signals between the FCL and the external processing device.

37. The system of claim 36, wherein the FCL further comprises:

a substrate for supporting electronic components and providing structural support for the functional contact lens; and

an antenna disposed on the substrate for transmitting the sensed signal to an external device, the antenna being coupled to the at least one sensing element,

wherein the at least one sensing element is disposed on the substrate for sensing the at least one target analyte and undergoing a physical change representing a sensed signal.

39. The system of claim 36, wherein communication between the FCL and the transceiver-reader device is bi-directional.

40. The system of claim 36, wherein the FCL directly communicates with the external reader device and the communication is bi-directional.

41. The system of claim 36, wherein at least one of the transceiver-reader device and the external reader device are configured to provide RF power signals to the FCL to wirelessly power the FCL.

42. The system of claim 36, wherein at least one of the transceiver-reader device and the external processing device are configured to perform at least one of processing and displaying received data from the FCL.

38. (canceled)