VACCINE
First Claim
1. Pharmaceutical combination of compositions for use in medical treatment, the combination comprising a first composition comprising dendritic cells (DC) which are immunologically compatible with a recipient and which are associated with a target antigen and a second composition comprising at least a portion of the target antigen in soluble form and a co-stimulatory antibody effective for activating T-cells and/or the dendritic cells (DC), wherein the second composition is for administration at a time at least 1 day subsequent to administration of the first composition.
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Accused Products
Abstract
The present invention relates to a pharmaceutical combination of compositions for use in the treatment or prevention of a disease having cells bearing a target antigen as a vaccine and to a method for vaccination of a mammal, especially of a human for raising a cellular immune response directed against cells of the mammalian recipient, especially human recipient, which cells express a target antigen. The target antigen can e.g. be an autoantigen like a malignant antigen, i.e. a tumour-specific antigen. The pharmaceutical combination of compositions comprises a first composition and a second composition, wherein the second composition is for administration to recipient subsequent to the administration of the first composition, e.g. 2 to 10 days after the first composition. The pharmaceutical combination of compositions has the advantage of raising an effective antigen-specific T-cell response against cells bearing a target antigen that can be a malignant autoantigen, e.g. for raising an antigen-specific T-cell response against cells bearing a tumour-antigen. A further advantage is that the pharmaceutical combination of compositions can raise an antigen-specific T-cell response within a comparatively short time.
11 Citations
19 Claims
- 1. Pharmaceutical combination of compositions for use in medical treatment, the combination comprising a first composition comprising dendritic cells (DC) which are immunologically compatible with a recipient and which are associated with a target antigen and a second composition comprising at least a portion of the target antigen in soluble form and a co-stimulatory antibody effective for activating T-cells and/or the dendritic cells (DC), wherein the second composition is for administration at a time at least 1 day subsequent to administration of the first composition.
- 3. Pharmaceutical combination of compositions for use in medical treatment, the combination comprising a first composition comprising an antibody specific for a surface receptor of a dendritic cell (DC) coupled to a target antigen and a second composition comprising at least a portion of the target antigen in soluble form and a co-stimulatory antibody effective for activating T-cells and/or dendritic cells (DC), wherein the second composition is provided for administration at a time at least 1 day subsequent to administration of the first composition.
Specification