FC-REGION VARIANTS WITH IMPROVED PROTEIN A-BINDING
First Claim
1. A polypeptide comprisinga first polypeptide and a second polypeptide each comprising in N-terminal to C-terminal direction at least a portion of an immunoglobulin hinge region, which comprises one or more cysteine residues, an immunoglobulin CH2-domain, and an immunoglobulin CH3-domain,wherein the first, or the second, or the first and the second polypeptide comprise the mutation Y436A (numbering according to the EU index).
6 Assignments
0 Petitions
Accused Products
Abstract
Herein is reported a polypeptide comprising a first polypeptide and a second polypeptide each comprising in N-terminal to C-terminal direction at least a portion of an immunoglobulin hinge region, which comprises one or more cysteine residues, an immunoglobulin CH2-domain and an immunoglobulin CH3-domain, wherein the first, the second, or the first and the second polypeptide comprise the mutation Y436A (numbering according to the EU index).
9 Citations
26 Claims
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1. A polypeptide comprising
a first polypeptide and a second polypeptide each comprising in N-terminal to C-terminal direction at least a portion of an immunoglobulin hinge region, which comprises one or more cysteine residues, an immunoglobulin CH2-domain, and an immunoglobulin CH3-domain, wherein the first, or the second, or the first and the second polypeptide comprise the mutation Y436A (numbering according to the EU index).
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12. (canceled)
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13. (canceled)
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15-19. -19. (canceled)
- 21. The method of claim 21, wherein the ocular disease is an ocular vascular disease.
Specification