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PD-1 Antibodies

  • US 20170044260A1
  • Filed: 08/09/2016
  • Published: 02/16/2017
  • Est. Priority Date: 08/10/2015
  • Status: Active Grant
First Claim
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1. An antibody that binds human PD-1 (SEQ ID NO:

  • 1), comprising a light chain (LC) and a heavy chain (HC), wherein the light chain comprises light chain complementarity determining regions LCDR1, LCDR2, and LCDR3 consisting of the amino acid sequences RASQGISSWLA (SEQ ID NO;

         9), SAASSLQS (SEQ ID NO;

         10), and QQANHLPFT (SEQ ID NO;

         11), respectively, and wherein the heavy chain comprises heavy chain complementarity determining regions HCDR1, HCDR2, and HCDR3, wherein HCDR1 consists of the amino acid sequences KASGGTFSSYAIS (SEQ ID NO;

         2) or KASGGTLSSYAIS (SEQ ID NO;

         3), wherein HCDR2 consists of the amino acid sequences LIIPMFGTAGYAQKFQG (SEQ ID NO;

         4), LIIPMFDTAGYAQKFQG (SEQ ID NO;

         5) or LIIPMFGAAGYAQRFQG (SEQ ID NO;

         6), and wherein HCDR3 consists of the amino acid sequences ARAEYSSTGTFDY (SEQ ID NO;

         7) or ARAEHSSTGTFDY (SEQ ID NO;

         8).

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