NEW BICYCLIC DERIVATIVES

• US 20170050960A1
• Filed: 10/12/2016
• Published: 02/23/2017
• Est. Priority Date: 09/25/2012
• Status: Abandoned Application

• Current Assignee: Hoffmann-La Roche Incorporated (Roche Holding AG)
• Original Assignee: Hoffmann-La Roche Incorporated (Roche Holding AG)
• Inventors: Hert, Jerome, Hunziker, Daniel, Mattei, Patrizio, Mauser, Harald, Tang, Guozhi, Wang, Lisha
• Application Number:
  US15/291,933
• Publication Number:
  US 20170050960A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61P 1/16 for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• CPC Class Codes: A61P 13/12 of the kidneys
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 37/06 Immunosuppressants, e.g. drugs for graft rejection
• CPC Class Codes: C07D 403/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 413/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 471/04 Ortho-condensed systems
• CPC Class Codes: C07D 487/04 Ortho-condensed systems
• CPC Class Codes: C07D 519/00 Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

The invention provides novel compounds having the general formula (I)

wherein R¹, Y, A, W, R², m, n, p and q are as described herein, compositions including the compounds and methods of using the compounds.

Claims

4-1. The compound of claim 1, wherein:

R¹ is substituted phenylalkyl or substituted phenylalkenyl, wherein substituted phenylalkyl and substituted phenylalkenyl are substituted with R⁸, R⁹ and R¹⁰.

15-1. The compound of claim 1, wherein R² is

24-1. The compound of claim 1, wherein R¹⁰ is H or alkyl.

25-1. The compound of claim 1, wherein R¹⁰ is H.

26-1. The compound of claim 1, wherein R¹¹ is haloalkyl.