METHOD AND APPARATUS FOR DETECTING SEIZURES

• US 20170065218A1
• Filed: 08/12/2016
• Published: 03/09/2017
• Est. Priority Date: 07/05/2011
• Status: Active Grant

• Current Assignee: Novela Neurotechnologies, Inc.
• Original Assignee: Brain Sentinel, Inc.
• Inventors: Leininger, James R., Herring, Russell M., Girouard, Michael R., Cavazos, Jose E., Jones, Edward R., Broad, William E.
• Granted Patent: US 9,833,185 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61B 2505/07 Home care
• CPC Class Codes: A61B 5/0004 characterised by the type of physiological signal transmitted
• CPC Class Codes: A61B 5/02055 Simultaneously evaluating both cardiovascular condition and temperature
• CPC Class Codes: A61B 5/296 for electromyography [EMG]
• CPC Class Codes: A61B 5/316 Modalities, i.e. specific diagnostic methods
• CPC Class Codes: A61B 5/318 Heart-related electrical modalities, e.g. electrocardiography [ECG]
• CPC Class Codes: A61B 5/389 Electromyography [EMG]
• CPC Class Codes: A61B 5/4094 Diagnosing or monitoring seizure diseases, e.g. epilepsy
• CPC Class Codes: A61B 5/7246 using correlation, e.g. template matching or determination of similarity
• CPC Class Codes: A61B 5/7267 involving training the classification device
• CPC Class Codes: A61B 5/7271 Specific aspects of physiological measurement analysis A61B5/316, A61B5/349 and A61B5/374 take precedence
• CPC Class Codes: A61B 5/746 Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms alarms per se G08B
• CPC Class Codes: G16H 40/67 for remote operation

Abstract

A method and apparatus for detecting seizures with motor manifestations including detecting EMG signals, isolating from the EMG signals spectral data for a plurality of frequency bands, and calculating a T-squared value there from. The T-squared values may be detected in real time, such as in a patient'"'"'s home environment, and the T-squared data may be compared to a threshold T-squared value to determine whether an alarm is sent.

Claims

1-28. -28. (canceled)

29. A method of detecting seizures with motor manifestations comprising the steps of:

detecting EMG signals for a time period, the time period comprising a reference period and a monitoring period;

using digital filtering to isolate from the EMG signals spectral data for a plurality of frequencies bands selected from the range of about 2 Hz to about 1000 Hz;

calculating a first PCA value, the first PCA value being determined from spectral data for the plurality of frequency ranges from at least one part of the reference period;

calculating a second PCA value, the second PCA value being determined from spectral data for the plurality of frequency ranges from at least one part of the monitoring period;

comparing the second PCA value to the first PA value; and

determining whether to trigger an alarm condition using said comparison of the first PCA value to the second PCA value.

30. The method of claim 29 wherein the comparison of the second PCA value to the first PCA value includes calculating a Z value comprising the number of standard deviations of the second PCA value from the first PCA value;

and

wherein said determining whether to trigger an alarm comprises calculating if the Z value exceeds a threshold Z value.

31. The method of claim 29, wherein the plurality of frequency bands comprises a first frequency band from about 300 Hz to about 400 Hz, a second frequency band from about 130 Hz to about 240 Hz, and a third frequency band from about 30 Hz to about 40 Hz.

32. The method of claim 30, wherein the alarm condition is not triggered until the Z value exceeds the threshold Z value for a set delay time period.

33. The method of claim 32, wherein the set delay time period is 2 or more seconds.

34. The method of claim 29, wherein the first and second PCA values are based on the first two principal components.

35. The method of claim 29 wherein the comparison of the second PCA value to the first PCA value includes calculating the difference between said second PCA value and said first PCA value;

wherein the determining of whether to trigger an alarm comprises a calculation of whether said difference is above a threshold PCA value.

36. The method of claim 35 further comprising collecting EMG signals while a patient is executing a maximum voluntary contraction and measuring a PCA value;

and

setting said threshold PCA value based on the PCA measured during the maximum voluntary contraction.

37. The method of claim 36 wherein the threshold PCA value is greater than the PCA value measured during the maximum voluntary contraction.

38-130. -130. (canceled)