OPHTHALMIC TREATMENT DEVICE, SYSTEM, AND METHOD OF USE

• US 20170065826A1
• Filed: 09/21/2016
• Published: 03/09/2017
• Est. Priority Date: 09/30/2010
• Status: Active Grant

• Current Assignee: CXL Ophthalmics, LLC
• Original Assignee: CXL Ophthalmics, LLC
• Inventors: Rubinfeld, Roy S., Feldman, Sandy T., Daly, Kevin E., Hartman, Raymond A.
• Granted Patent: US 10,285,857 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61F 2009/00865 Sclera
• CPC Class Codes: A61F 2009/00872 Cornea
• CPC Class Codes: A61F 2009/00893 Keratoconus
• CPC Class Codes: A61F 9/0079 using non-laser electromagnetic radiation, e.g. non-coherent light or microwaves
• CPC Class Codes: A61F 9/008 using laser
• CPC Class Codes: A61F 9/013 Instruments for compensation of ocular refraction A61F9/008 takes precedence; Instruments for use in cornea removal, for reshaping or performing incisions in the cornea
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/525 Isoalloxazines, e.g. riboflavins, vitamin B2
• CPC Class Codes: A61K 38/44 Oxidoreductases (1)
• CPC Class Codes: A61K 41/0066 Psoralene-activated UV-A photochemotherapy (PUVA-therapy), e.g. for treatment of psoriasis or eczema, extracorporeal photopheresis with psoralens or fucocoumarins
• CPC Class Codes: A61K 49/0015 Phosphorescence
• CPC Class Codes: A61K 9/0048 Eye, e.g. artificial tears
• CPC Class Codes: A61K 9/08 Solutions composition of solutions A61K47/00
• CPC Class Codes: A61N 2005/0626 Monitoring, verifying, controlling systems and methods
• CPC Class Codes: A61N 2005/0652 Arrays of diodes
• CPC Class Codes: A61N 2005/0661 ultraviolet
• CPC Class Codes: A61N 2005/0663 Coloured light
• CPC Class Codes: A61N 2005/0667 Filters
• CPC Class Codes: A61N 5/062 Photodynamic therapy, i.e. excitation of an agent
• CPC Class Codes: A61N 5/067 using laser light

Abstract

Ophthalmic treatment systems and methods of using the systems are disclosed. The ophthalmic treatment systems include (a) a light source device; (b) at least one optical treatment head operatively coupled to the light source device, comprising a light source array, and providing at least one treatment light; and (c) a light control device, which (i) provides patterned or discontinuous treatment light projection onto an eye (e.g., the cornea and/or sclera of an eye); or (ii) adjusts intensity of part or all of the light source array, providing adjusted intensity treatment light projection onto an eye (e.g., the cornea and/or sclera of an eye). The at least one treatment light promotes corneal and/or scleral collagen cross-linking.

Claims

1. An ophthalmic treatment system, comprising:

a light source device;

at least one optical treatment head operatively coupled to the light source device, and providing at least one treatment light; and

a light control device, which controls operation of the light source to provide discontinuous treatment light projection onto an eye; and

/or adjusts intensity of part or all of the light source, providing adjusted intensity treatment light projection onto an eye.

2. The system of claim 1, wherein the light control device is configured to provide discontinuous treatment light projection from the optical treatment head onto the cornea and/or sclera at a treatment light exposure period of between one second and 10 minutes.

3. The system of claim 2, wherein the controller has an input for operator selection of parameters and duration for the discontinuous light projection on the cornea and/or sclera.

4. The system of claim 2, wherein each treatment light exposure period of the discontinuous treatment light projection is in the range from 5 seconds to 25 seconds.

5. The system of claim 1, wherein the treatment light is selected from the group consisting of UVA light, a mixture of UVA and blue light, and blue light.

6. The system of claim 1, wherein the controller further comprises a control module for dimming the treatment light intensity to a low level prior to the end of each treatment light exposure period and prior to the next treatment light exposure period, and for increasing the treatment light intensity gradually to a maximum treatment light intensity at the start of each treatment light exposure period.

7. The system of claim 1, further comprising an anti-startle light, wherein the control device is configured to direct the anti-startle light towards an eye of a patient under treatment between treatment light exposure periods and switch off the anti-startle light during treatment light exposure periods.

8. The system of claim 1, further comprising an optical projection device configured to direct the at least one treatment light onto a portion of an eye.

9. The system of claim 1, further comprising an intensity control device which adjusts intensity of part or all of the light source, providing the adjusted intensity treatment light projection onto the eye.

10. The system of claim 1, further comprising a pattern control device which provides patterned treatment light projection onto the eye.

11. The system of claim 10, wherein the pattern control device is part of a light mask.

12. The system of claim 1, further comprising an optical sensor device, wherein the control of the discontinuous treatment light, or the adjusting of the intensity of part or all of the light source, is controlled or adjusted according to data collected from the optical sensor device.

13. The system of claim 1, further comprising a fixation light upon which an eye is focused during treatment.

14. The system of claim 1, wherein the light source device comprises at least one single-wavelength light source.

15. The system of claim 1, wherein said at least one optical treatment head comprises first and second optical treatment heads each including projection optics and configured to project respective treatment light onto the right and left eyes at a working distance of from two to six inches from the optical treatment heads.

16. A method of producing a treatment light for use in phototherapy treatment of an eye, comprising:

directing at least one light beam of at least one predetermined wavelength band from a light source along a predetermined light path from the light source to an outlet of at least one optical treatment head;

projecting the light beam from the outlet of the optical treatment head towards one eye of a patient and focusing the beam to produce at least one light spot of predetermined size and shape on the eye at a predetermined working distance from the optical treatment head, whereby the optical treatment head is positioned at a distance from the eye sufficient to allow access to the eye; and

controlling the light source or projected light beam to provide discontinuous treatment light projection onto the eye at a selected cycle frequency.

17. The method of claim 16, wherein the selected cycle frequency is between one second and 10 minutes.

18. The method of claim 16, wherein providing discontinuous treatment light projection onto the eye comprises controlling the light source to produce a discontinuous treatment light output.

19. The method of claim 16, wherein the light intensity is at a first level during each treatment light exposure period and at a second, lower level between successive treatment light exposure periods, and the intensity control device is configured to increase the treatment light intensity gradually from the second level to the first level at the start of each treatment light exposure period and to dim the treatment light gradually from the first level to the second level prior to the end of each treatment light exposure period.

20. The method of claim 16, further comprising wiping the surface of the eye with a sponge to disrupt the epithelium, and applying a riboflavin photosensitizer solution to the epithelium to penetrate through the epithelium into the corneal stroma before projecting the light beam onto the eye.