MODIFIED POLYMERASES FOR REPLICATION OF THREOSE NUCLEIC ACIDS
First Claim
Patent Images
1. A nucleic acid encoding a TNA polymerase comprising an amino acid sequence at least 95% identical to SEQ ID NO:
- 1, wherein the residue corresponding to 141 of SEQ ID NO;
1 is an alanine, residue 143 is an alanine, residue 485 is an arginine, and residue 664 is an isoleucine; and
wherein the encoded DNA polymerase synthesizes a TNA in the presence of a DNA template and threose nucleotides.
0 Assignments
0 Petitions
Accused Products
Abstract
Methods and compositions for replication of threose nucleic acids (TNAs) are described. The described methods include a method for transcribing a DNA template into a TNA, and a method for reverse transcribing a threose nucleic acid into a cDNA.
-
Citations
9 Claims
-
1. A nucleic acid encoding a TNA polymerase comprising an amino acid sequence at least 95% identical to SEQ ID NO:
- 1, wherein the residue corresponding to 141 of SEQ ID NO;
1 is an alanine, residue 143 is an alanine, residue 485 is an arginine, and residue 664 is an isoleucine; and
wherein the encoded DNA polymerase synthesizes a TNA in the presence of a DNA template and threose nucleotides. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
- 1, wherein the residue corresponding to 141 of SEQ ID NO;
Specification