TRANSCUTANEOUS ANALYTE SENSORS AND MONITORS, CALIBRATION THEREOF, AND ASSOCIATED METHODS
First Claim
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1. A method of calibrating an analyte concentration sensor within a biological system, using a signal from the analyte concentration sensor, wherein at a steady state, the analyte concentration value within the biological system is known, comprising:
- on a monitoring device, receiving a seed value of a calibration parameter;
on the monitoring device, detecting when an analyte concentration value as measured by an analyte concentration sensor indwelling in a biological system is at a steady state; and
on the monitoring device or on a device or server operatively coupled to the monitoring device, correlating a measurement of the analyte concentration value when the biological system is at the detected steady state to the known analyte concentration value;
subsequent to the correlating, receiving a signal from the sensor; and
calculating and displaying a value corresponding to the received signal, the calculated value based on the received signal, the known analyte concentration value, and the seed value.
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Abstract
Systems and methods are provided to calibrate an analyte concentration sensor within a biological system, generally using only a signal from the analyte concentration sensor. For example, at a steady state, the analyte concentration value within the biological system is known, and the same may provide a source for calibration. Similar techniques may be employed with slow-moving averages. Variations are disclosed.
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Citations
24 Claims
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1. A method of calibrating an analyte concentration sensor within a biological system, using a signal from the analyte concentration sensor, wherein at a steady state, the analyte concentration value within the biological system is known, comprising:
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on a monitoring device, receiving a seed value of a calibration parameter; on the monitoring device, detecting when an analyte concentration value as measured by an analyte concentration sensor indwelling in a biological system is at a steady state; and on the monitoring device or on a device or server operatively coupled to the monitoring device, correlating a measurement of the analyte concentration value when the biological system is at the detected steady state to the known analyte concentration value; subsequent to the correlating, receiving a signal from the sensor; and calculating and displaying a value corresponding to the received signal, the calculated value based on the received signal, the known analyte concentration value, and the seed value. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. An analyte concentration sensor system, comprising:
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an analyte concentration sensor configured to be calibrated within a biological system, using a signal from the analyte concentration sensor, wherein at a steady state, the analyte concentration value within the biological system is known; a processor comprising a component of a monitoring device or a device or server operatively connected to the monitoring device, wherein the processor is configured to; receive a seed value of a calibration parameter; detect when an analyte concentration value as measured by the analyte concentration sensor indwelling in a biological system is at a steady state; correlate a measurement of the analyte concentration value when the biological system is at the detected steady state to the known analyte concentration value;
thereafterreceive a signal from the sensor; and calculate a value corresponding to the received signal, the calculated value based on the received signal, the known analyte concentration value, and the seed value; and a display device, wherein the display device is configured to display the calculated value. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24)
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Specification